Results 231 to 240 of about 2,294,345 (331)

AI-Ready Training Datasets for Earth Observation: Enabling FAIR data principles for EO training data.

, 2021
Alastair McKinstry, Oisín Boydell, Quan Le, Inder Preet, Jenny Hanafin, Manuel García-Quismondo Fernández, Adam Warde, V. Kannan, Patrick Griffiths   +8 more
openalex   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

A practical guide to FAIR data management in the age of multi-OMICS and AI. [PDF]

Front Immunol
Mugahid D, Lyon J, Demurjian C, Eolin N, Whittaker C, Godek M, Lauffenburger D, Fortune S, Levine S.   +8 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

The state of food composition databases: data attributes and FAIR data harmonization in the era of digital innovation. [PDF]

Front Nutr
Brinkley S, Gallo-Franco JJ, Vázquez-Manjarrez N, Chaura J, Quartey NKA, Toulabi SB, Odenkirk MT, Jermendi E, Laporte MA, Lutterodt HE, Annan RA, Barboza M, Amare E, Srichamnong W, Jaramillo-Botero A, Kennedy G, Bertoldo J, Prenni JE, Rajasekharan M, de la Parra J, Ahmed S.   +20 more
europepmc   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Enhancing mental health outcomes through a theory of change: supporting open-source data science platforms to promote FAIR data and evidence-based decisions. [PDF]

BMC Health Serv Res
Mugotitsa B, Andeso P, Owoko H, Momanyi R, Mailosi D, Ssebunnya J, Tsofa B, Greenfield J, Kiragga A, Todd J, INSPIRE network.   +10 more
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

FAIR data management: a framework for fostering data literacy in biomedical sciences education. [PDF]

BMC Med Res Methodol
Gonzalez Soltero R, Pino García D, Bellido A, Ryan P, Rodríguez-Learte AI.   +4 more
europepmc   +1 more source

Associating live analytical data to synthetic chemistry experiments: Applying FAIR principles across the scientific experimentation lifecycle

, 2020
Leah McEwen, Michael Boruta
openalex   +1 more source