Results 161 to 170 of about 219,223 (326)

Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review

British Journal of Pharmacology, EarlyView.
Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos, Stavros Topouzis, Steve P. H. Alexander, Miriam M. Cortese‐Krott, Zsuzsanna Helyes, Kirill Martemyanov, Claudio Mauro, Nithyanandan Nagercoil, Reynold A. Panettieri Jr, Hemal H. Patel, Rainer Schulz, Barbara Stefanska, Gary J. Stephens, Nathalie Vergnolle, Xin Wang, Stephen Ward, Péter Ferdinandy   +16 more
wiley   +1 more source

L1CAM Promotes the Infiltrative Properties of Patient‐Derived Glioblastoma Cells

Cancer Science, EarlyView.
In vivo validation of L1CAM‐mediated GBM infiltration. Orthotopic transplantation of L1CAM‐expressing GBM cells into mouse brains demonstrated that L1CAM significantly promotes tumor cell infiltration and expansion in the brain parenchyma, confirming its critical role in the aggressive progression of GBM.
Asako Katsuma, Daisuke Kanematsu, Yukako Handa, Tomoko Shofuda, Atsuyo Yamamoto, Kayo Nishitani, Zhize Xiao, Daisuke Kawauchi, Kentarou Baba, Naoyuki Inagaki, Yonehiro Kanemura   +10 more
wiley   +1 more source

The Role of FAK ( Focal Adhesion Kinase) in Fertilization of Starfish Asterina Miniata PLC [PDF]

, 2015
Rana Hussein Naser Al-Qaysi
openalex   +1 more source

O-GlcNAcylation of Focal Adhesion Kinase Regulates Cell Adhesion, Migration, and Proliferation via the FAK/AKT Pathway

Biomolecules
Focal Adhesion Kinase (FAK) is a non-receptor tyrosine kinase pivotal in cellular signal transduction, regulating cell adhesion, migration, growth, and survival. However, the regulatory mechanisms of FAK during tumorigenesis and progression still need to
Zhiwei Zhang, Tomoya Isaji, Yoshiyuki Oyama, Jianwei Liu, Zhiwei Xu, Yuhan Sun, Tomohiko Fukuda, Haojie Lu, Jianguo Gu   +8 more
doaj   +1 more source

Decoding the Role of Caveolin‐1 in Morphological Diversity and Self‐Renewal of Breast Cancer Cells

Cell Proliferation, EarlyView.
The silence of caveolin‐1 (Cav‐1) reproduced the morphological evolutionary behaviour of cancer cells, which is similar to the epithelial‐mesenchymal transition process. And Cav‐1 dependent morphological changes could affect cancer cell self‐renewal capacity through maintaining the morphological stability.
Shun Li, Hongyun Duan, Lu Yang, Lingyi Jiang, Haocheng Bian, Yuqin Jiang, Yixi Zhang, Wei Yan, Qin Yang, Tingting Li, Xiang Qin, Zong‐Yuan Liu, Ningwei Sun, Kai‐fu Yang, Yiyao Liu   +14 more
wiley   +1 more source

P130cas-FAK interaction is essential for YAP-mediated radioresistance of non-small cell lung cancer [PDF]

, 2022
Jingduo Li, Xiupeng Zhang, Zaiyu Hou, Siqi Cai, Yingxue Guo, Limei Sun, Ailin Li, Qingchang Li, Enhua Wang, Yuan Miao   +9 more
openalex   +1 more source

Književnost FAK-a [PDF]

, 2017
U ovom radu govori se o Festivalu A književnosti koji je pomogao hrvatskoj književnosti, što putem medija, što sa gostujućim stranim autorima, da se proslavi među druge države i kontinente. Bili su to festivali na kojima je sve bilo dozvoljeno. Njegovi pokretači bili su Nenad Rizvanović, Kruno Lokotar, Borivoj Radaković i Hrvoje Osvadić.
openaire   +1 more source

AMSC‐sEVs Ameliorated Crohn's Disease by Inhibiting Macrophage‐Myofibroblast Transition Through the Delivery of MFGE8

Cell Proliferation, EarlyView.
Our study demonstrated that TGF‐β1 activated MAPK signalling pathway and promoted the MMT and secretion of CCL17 under CD‐associated intestinal inflammatory conditions. AMSC‐sEVs can deliver MFGE8, which inhibits MMT and CCL17‐mediated Treg recruitment by suppressing the MAPK signalling pathway, thereby alleviating intestinal fibrosis.
Minghao Xie, Qiang Liu, Zhizhong Xiong, Jian Li, Ruiri Jin, Lei Lian, Zhengrong Li   +6 more
wiley   +1 more source

Proteome Analysis of Focal Adhesion Kinase (FAK)-Overexpressing Cells

, 2004
Ryoko Utsubo, Yoshiko Sonoda, Reiko Takahashi, Shiro Iijima, Eriko Aizu-Yokota, Tadashi Kasahara   +5 more
openalex   +2 more sources

Mechanobiology in Stem Cell‐Based Bioprinting

Cell Proliferation, EarlyView.
Mechanobiology in stem cell‐based bioprinting is an emerging field that bridges the mechanical conditions of the bioprinting process with the regulation of stem cell behaviour for engineering living tissues. Stresses encountered during bioprinting, together with the mechanical properties of bioinks, play a critical role in regulating stem cell ...
Supeng Ding, Tiankun Liu, Rui Yao
wiley   +1 more source