Results 41 to 50 of about 4,739,983 (297)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

A Response-Adaptive Method for Design of Validation Experiments in Computational Mechanics

Applied Sciences, 2020
For model verification and validation (V & V) in computational mechanics, a hypothesis test for the validity check (HTVC) is useful, in particular, with a limited number of experimental data.
Byung C. Jung, Yun-Ho Shin, Sang Hyuk Lee, Young Cheol Huh, Hyunseok Oh   +4 more
doaj   +1 more source

Real-Time In Situ Navigation System With Indocyanine Green Fluorescence for Sentinel Lymph Node Biopsy in Patients With Breast Cancer

Frontiers in Oncology, 2021
BackgroundThe naked-eye invisibility of indocyanine green fluorescence limits the application of near-infrared fluorescence imaging (NIR) systems for real-time navigation during sentinel lymph node biopsy (SLNB) in patients with breast cancer undergoing ...
Zhaorui Wang, Xiaowei Yang, Jingjing Wang, Peng Liu, Yubo Pan, Chunguang Han, Jing Pei   +6 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

SARS-CoV-2 rapid antigen testing in the healthcare sector: A clinical prediction model for identifying false negative results

International Journal of Infectious Diseases, 2021
Objectives: SARS-CoV-2 rapid antigen tests (RAT) provide fast identification of infectious patients when RT-PCR results are not immediately available. We aimed to develop a prediction model for identification of false negative (FN) RAT results.
Johannes Leiner, MD, Vincent Pellissier, PhD, Anne Nitsche, PhD, Sebastian König, MD, Sven Hohenstein, PhD, Irit Nachtigall, MD, Gerhard Hindricks, MD, Christoph Kutschker, MD, Boris Rolinski, MD, Julian Gebauer, MD, Anja Prantz, MD, Joerg Schubert, MDPhD, Joerg Patzschke, MD, Andreas Bollmann, MDPhD, Martin Wolz, MD   +14 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

False-negative and false-positive rates per quarter, April 2012-June 2014.

, 2016
False-negative and false-positive rates per quarter, April 2012-June 2014.
Pedro G. Suarez (2795539), Genetu Alem (3176130), Dereje Habte (235296), Belaineh Girma (95494), Muluken Melese (34781), Yewulsew Kassie (2795530), Gonfa Ayana (466721), Solomon Negash (2795545), Feleke Belachew (3176136), Jemal Seid (3176133), Nebiyu Hiruy (2795551), Yared K. Haile (2795548), Degu Jerene (75554)   +12 more
core   +1 more source

Definitions of true positive (TP), true negative (TN), false positive (FP), and false-negative (FN).

, 2023
Definitions of true positive (TP), true negative (TN), false positive (FP), and false-negative (FN).
Jayaraman Thangappan (16920766), Sangwook Wu (8352264), Mandar Kulkarni (300092), Indrajit Deb (1816168)   +3 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source