Results 61 to 70 of about 4,739,983 (297)

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

True positive, false positive, false negative for category 1.

, 2023
True positive, false positive, false negative for category 1.
Muddassar Azam Sindhu (8735385), Rabeeh Ayaz Abbasi (12999930), Maryam Imtiaz Malik (16436742)   +2 more
core   +1 more source

An analysis of the influencing factors of false negative autoantibodies in patients with non-small cell lung cancer

Frontiers in Oncology
ObjectivesTo analyze the clinical significance of seven autoantibodies (P53, PGP9.5, SOX2, GAGE7, GBU4-5, MAGE, and CAGE) in patients with non-small cell lung cancer (NSCLC) and the factors that influence false-negative results.MethodsSeven ...
Ailin Wang, Ying Hao, Yunlong Huo, Xiaoman Xu, Yi Zhang   +4 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

False negative rate exceeds false positive rate.

, 2013
A) Posterior distributions of false discovery rate (FDR) and false non-discovery rate (FNDR) estimated by Markov chain Monte Carlo using multi-study influenza RNAi data and the statistical model of multi-study agreement.
Qiuling He (208655), Mark Craven (51222), Michael A. Newton (204762), Linhui Hao (208653), Paul Ahlquist (78214), Zhishi Wang (460794)   +5 more
core   +1 more source

Impact of Improper Approach to Identify Lid Wiper Epitheliopathy (LWE)

Clinical Ophthalmology, 2020
Christopher W Lievens,1 Yvonne Norgett,2 Nancy Briggs,3 Peter M Allen,4 Marta Vianya-Estopa2 1The Eye Center, Southern College of Optometry, Memphis, TN, USA; 2Department of Vision & Hearing Sciences, Anglia Ruskin University, Cambridge, UK; 3Mark ...
Lievens CW, Norgett Y, Briggs N, Allen PM, Vianya-Estopa M   +4 more
doaj  

Relationship between Non-Technical Factors and Diagnostic Accuracy of Frozen Section in Axillary Lymph Nodes in Patients with Breast Cancer

Journal of Mazandaran University of Medical Sciences, 2022
Background and purpose: Regional lymph node involvement is one of the main prognostic factors for breast cancer. Intraoperative assessment of sentinel lymph node biopsy (SLNB) by frozen section (FS) allows necessary axillary lymph node dissection (ALND ...
Vahid Zangouri, Navid Omidifar, Mohammad Heshmati, Aliyeh Ranjbar, Mansoureh Shokripour   +4 more
doaj  

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

True positive, false positive, false negative for category 2.

, 2023
True positive, false positive, false negative for category 2.
Muddassar Azam Sindhu (8735385), Rabeeh Ayaz Abbasi (12999930), Maryam Imtiaz Malik (16436742)   +2 more
core   +1 more source