Results 71 to 80 of about 4,739,983 (297)

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

False Mirror Office. Foretaste [PDF]

This volume features a miscellanea of images taken from the architectural designs by the Genoa-based collective firm false mirror office ...
Glorialanza, Giovanni, Fanciotti, Filippo, Hamzeian, Boris, Anselmo, Andrea, Castellini, Gloria   +4 more
core  

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

The Negative Consequences of False Negative Lung Cancer Screenings

Translation, 2023
Hoda Shabpiray, Mani Khorsand Askari, Jerrin George   +2 more
doaj   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

High false negative rate of Tc-99m MDP whole-body bone scintigraphy in detecting skeletal metastases for patients with hepatoma

Journal of the Formosan Medical Association, 2012
Technetium-99m methylene diphosphonate (Tc-99m MDP) whole-body bone scintigraphy (BS) has been widely used for detecting bone metastases. The aim of this study is to investigate the diagnostic accuracy of BS in detecting skeletal metastases for ...
Chih-Yu Chen, Karl Wu, Wei-Hsin Lin, Tsung-Yu Lan, Shan-Ying Wang, Jui-Sheng Sun, Pei-Wei Weng, Ruoh-Fang Yen, Rong-Sen Yang   +8 more
doaj   +1 more source

Effect of urine adulterants on commercial drug abuse screening test strip results

Arhiv za Higijenu Rada i Toksikologiju, 2020
Immunochromatographic strips for urine drug screening tests (UDSTs) are common and very suitable for drug abuse monitoring, but are also highly susceptible to adulterants kept in the household, which can significantly alter test results.
Rajšić Ivana, Javorac Dragana, Tatović Simona, Repić Aleksandra, Đukić-Ćosić Danijela, Đorđević Snežana, Lukić Vera, Bulat Zorica   +7 more
doaj   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

A multiple detection state occupancy model using autonomous recordings facilitates correction of false positive and false negative observation errors

Avian Conservation and Ecology, 2019
Bird surveys have relied upon acoustic cues for species identification for decades; however, errors in detection and identification can lead to misclassification of the site occupancy state. Although significant improvements have been made to correct for
Robert S. Rempel, Janet M. Jackson, Steven L. Van Wilgenburg, Jennifer A. Rodgers   +3 more
doaj  

False Negative Sample Detection for Graph Contrastive Learning

Tsinghua Science and Technology
Recently, self-supervised learning has shown great potential in Graph Neural Networks (GNNs) through contrastive learning, which aims to learn discriminative features for each node without label information.
Binbin Zhang, Li Wang
doaj   +1 more source