A Fatal Case of Herpes Simplex Encephalitis with Two False-Negative Polymerase Chain Reactions [PDF]
An 88-year-old man presented with a 1-month history of altered mental status and seizures. His electrographic and imaging findings were suggestive of herpes simplex encephalitis (HSE), for which he was empirically treated with acyclovir. He underwent two
Aldo A. Mendez +5 more
doaj +4 more sources
False-negative reactions to the comparative intradermal tuberculin test for bovine tuberculosis [PDF]
: According to the Brazilian National Program for the Control and Eradication of Animal Brucellosis and Tuberculosis (PNCEBT), the routine tests for the diagnosis of bovine tuberculosis in the country are the simple intradermal tuberculin test (SITT) of ...
Rudielle A. Rodrigues +7 more
doaj +4 more sources
False negative result of polymerase chain reaction in very early stages of acute retinal necrosis [PDF]
Abstract Background Viral nucleic acid testing of intraocular fluid using polymerase chain reaction (PCR) is a major laboratory examination in the diagnosis of acute retinal necrosis (ARN). Importantly, false negative PCR results may occur in several special situations.
Haibo Wang +8 more
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False negative polymerase chain reaction on cerebrospinal fluid samples in tuberculous meningitis [PDF]
There have been few studies in the literature concerned solely with the use of the polymerase chain reaction (PCR) to identify Mycobacterium tuberculosis DNA directly from CSF.1-4 These studies suggest that in some cases, PCR may be more sensitive than culture; however, in the largest study, performed …
D M, Gascoyne-Binzi, P M, Hawkey
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False negative diagnostic errors with polymerase chain reaction for the detection of cryptococcal meningoencephalitis [PDF]
Abstract The accuracy of the BioFire FilmArray Meningitis/Encephalitis (ME) panel for the identification of Cryptococcus has recently been called into question. The primary objective of this study was to assess the agreement between the BioFire ME polymerase chain reaction (PCR) and other markers of cryptococcal infection.
Matthew A Krolikowski +4 more
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False-Positive Clostridium difficile in Negative-Control Reactions Peak and Then Decrease with Repetitive Refrigeration of Immunoassay [PDF]
Aberrant false-positive reactions in negative-controls during ELISA testing for Clostridium difficile indicated the potential for false-diagnoses. Experiments with 96-well products showed a maximum peak of false-positive immunoassay reactions with the provided negative-control reagents after 5 refrigeration-to-room temperature cycles (P<0.001 ...
Alexander Rodriguez-Palacios +2 more
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S-gene Dropout and False-negative Reverse Transcriptase-polymerase Chain Reaction Tests
SM Balaji
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Polyethylene glycol modified LAMP assay enables sensitive and specific clinical detection of varicella-zoster virus [PDF]
Accurate, timely diagnosis of varicella–zoster virus (VZV) is important for treatment and infection control. While loop-mediated isothermal amplification (LAMP) is operationally simple, nonspecific priming can degrade performance.
Lei Zhang +8 more
doaj +2 more sources
False negative polymerase chain reaction on cerebrospinal fluid samples in tuberculous meningitis established by culture [PDF]
The polymerase chain reaction (PCR) has been reported to be of diagnostic value when performed on CSF samples in tuberculous meningitis.1-4 Rapid amplification of Mycobacteruim tuberculosis specific DNA enables results to be available within 48 hours and can influence treatment decisions.
M MELZER +4 more
openaire +2 more sources
A Patient with COVID-19 Presenting a False-Negative Reverse Transcriptase Polymerase Chain Reaction Result [PDF]
Zuhua Chen +5 more
openaire +4 more sources

