Results 81 to 90 of about 3,555,724 (288)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

The impact of White Shark (Carcharodon carcharias) sightings and attacks on recreational water use patterns in False Bay [PDF]

, 2013
White sharks (Carcharodon carcharias) are apex predators that play an important role in the structure and functioning of marine ecosystems. However, despite both their ecological importance and threatened conservation status this species is still subject
Engelbrecht, Tamlyn
core   +1 more source

Assessment of target detection limits in hyperspectral data

, 2022
Paper 96530J, 10 S.Hyperspectral remote sensing data can be used for civil and military applications to detect and classify target objects that cannot be reliably separated using broadband sensors.
Oechslin, R., Gross, W., Kneubuehler, M., Middelmann, W., Weyermann, J., Boehler, J., Schilling, H., Wellig, P.   +7 more
core   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

TFCD-Net: Target and False Alarm Collaborative Detection Network for Infrared Imagery

Remote Sensing
Infrared small target detection (ISTD) plays a crucial role in both civilian and military applications. Detecting small targets against dense cluttered backgrounds remains a challenging task, requiring the collaboration of false alarm source elimination ...
Siying Cao, Zhi Li, Jiakun Deng, Yi’an Huang, Zhenming Peng   +4 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Multiple-Target Matching Algorithm for SAR and Visible Light Image Data Captured by Multiple Unmanned Aerial Vehicles

Drones
Unmanned aerial vehicle (UAV) technology has witnessed widespread utilization in target surveillance activities. However, cooperative multiple UAVs for the identification of multiple targets poses a significant challenge due to the susceptibility of ...
Hang Zhang, Jiangbin Zheng, Chuang Song
doaj   +1 more source

Pro-social motive promotes early understanding of false belief [PDF]

, 2008
Ever since Premack & Woodruff's classic article^1^, which introduced the term "theory of mind", researchers have claimed that strategic deception is the most natural behavioural consequence of understanding false belief.
Tomoko Matsui, Yui Miura
core  

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source