Results 51 to 60 of about 15,474 (237)

A Machine Vision‐Guided Microphysiological Platform With Automated Microfluidics Enables Longitudinal Biomarker Monitoring and Emulation of Translationally Relevant Exposure Scenarios

Advanced Science, EarlyView.
A pneumatically actuated multi‐tissue microphysiological system is integrated with AI‐based machine vision and automatic sampling and replenishment systems. The platform allows for the emulation of translationally relevant long‐term pharmacokinetic exposure scenarios for multiple weeks while enabling longitudinal monitoring of response biomarkers ...
Jibbe Keulen, Yi Zhong, Laura Dangel, Sonia Youhanna, Reza Zandi Shafagh, Jinhye Ryu, Domnica‐Gabriela Gurau, Mathias Haag, Thomas E. Mürdter, Yingxin Liang, Iro Beligiani, Nicole Ziegler, Sabine Willems, Nayere Taebnia, Wouter van der Wijngaart, Volker M. Lauschke   +15 more
wiley   +1 more source

Closing the Empirical Loop: Autonomous AI Agents Conduct End‐to‐end Research With Human Participants

Advanced Science, EarlyView.
A multi‐agent AI system autonomously executes the complete scientific workflow, from hypothesis to manuscript, across three psychological studies involving 288 participants. The system designs experiments, collects real world data, develops analysis pipelines, and writes manuscripts with theoretical rigor comparable to experienced researchers.
Gabrielle Wehr, Reuben Rideaux, Amaya J. Fox, David R. Lightfoot, Jason Tangen, Jason B. Mattingley, Shane E. Ehrhardt   +6 more
wiley   +1 more source

Seafood procurement auctions in the presence of origin falsification: Price-only auction versus scoring auction.

PLoS ONE
Origin falsification in seafood procurement is a significant issue that threatens supply chain integrity and distorts market competition. Despite advances in origin detection technologies, this problem persists, particularly when penalty mechanisms lack ...
Shangjun Piao, Jiantao Guo
doaj   +1 more source

Falsification-Based Robust Adversarial Reinforcement Learning [PDF]

, 2023
Reinforcement learning (RL) has achieved enormous progress in solving various sequential decision-making problems, such as control tasks in robotics. Since policies are overfitted to training environments, RL methods have often failed to be generalized ...
Nair, Saasha, Althoff, Matthias, Wang, Xiao   +2 more
core   +1 more source

High‐Density E. Coli Cultivation Arrays for Combinatorial Drug Testing With Subsequent Lipid Profiling by MALDI‐MS

Advanced Science, EarlyView.
High‐throughput antibiotic cross‐gradient assays on microdroplet arrays. A multichannel printhead together with five pressure regulators forms droplet arrays of up to 20 832 droplets within 25 minutes. Each droplet contains unique concentrations of antibiotics, allowing to moniture a vast spectrum of bacterial repsonses over night. The bacterial growth
M. Breitfeld, C. L. Dietsche, F‐L. Born, I. Onipko, L. Blaase, P. S. Dittrich   +5 more
wiley   +1 more source

Fabrication, falsification and plagiarism [PDF]

QJM: An International Journal of Medicine, 2003
‘Many people say that it is the intellect which makes a great scientist. They are wrong: it is character’ —Albert Einstein The Office of Research Integrity of the USA (ORI) issued its annual report for 2001 at the end of last year. It is available on the Internet at [http://ori.dhhs.gov/html/publications/annual‐reports.asp], and anyone interested in ...
openaire   +3 more sources

Asymmetric Single‐Atom Catalysts Govern Diffusible and Non‐Diffusible Non‐Radical Pathways for Selective Degradation of Antibiotic Resistance Genes

Advanced Science, EarlyView.
Asymmetric single‐atom metal‐nitrogen‐carbon catalysts modulate the non‐radical pathway during peroxymonosulfate (PMS) activation. A fundamental contrast was revealed between diffusible singlet oxygen (1O2) and non‐diffusible electron‐transfer pathways (ETP) in antibiotic resistance gene (ARG) degradation.
Chen Gao, Jun Sun, Liang Zhang, Litao Lin, Zongfeng Wan, Bingcai Pan, Sheng Tang   +6 more
wiley   +1 more source

Toward Material‐Specific Peptides From in Silico Guided Peptide Engineering to Target PET in the Presence of PS

Advanced Science, EarlyView.
This work presents a computational–experimental strategy to engineer material‐binding peptides toward polymer specificity. Molecular dynamics simulations identified residues driving polystyrene binding, enabling targeted substitutions that greatly reduced polystyrene affinity while preserving PET binding.
Julian Luka, Marian Bienstein, Jonas Berger, Ulrich Schwaneberg   +3 more
wiley   +1 more source

La falsification méthodologique sophistiquée [PDF]

Imre Lakatos a proposé une modification du critère de Popper, qu'il a qualifié de « falsification sophistiquée (méthodologique) ». De ce point de vue, le critère de délimitation ne devrait pas s'appliquer à une hypothèse ou à une théorie isolée, mais ...
Sfetcu, Nicolae
core   +2 more sources

The phenomenon of collaborationism in the territories of the USSR occupied by Nazi Germany (1941–1944): Points of view and assessment in historiography [PDF]

Известия Саратовского университета. Новая серия: История. Международные отношения
An extensive domestic and foreign historiography has been created on the topic of collaborationism and related problems. The purpose of this work is to consider the phenomenon of collaborationism and the forms of its manifestation in the temporarily ...
Malysheva, Elena M.
doaj   +1 more source