Results 1 to 10 of about 4,211 (172)

Targeting FAM134B-DDX3X axis inhibiting AKT signaling in hepatocellular carcinoma [PDF]

Cell Death and Disease
Family with sequence similarity 134, member B (FAM134B), known for its role as an ER-phagy receptor, has been implicated in the promotion of hepatocellular carcinoma (HCC) progression through the activation of the AKT signaling pathway.
Jie Mo, Chen Su, Qiumeng Liu, Pengcheng Li, Lei Xu, Xin Long, Huifang Liang, Bixiang Zhang, Jin Chen   +8 more
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Cancer cells adapt FAM134B/BiP mediated ER-phagy to survive hypoxic stress [PDF]

Cell Death and Disease, 2022
In the tumor microenvironment, cancer cells experience hypoxia resulting in the accumulation of misfolded/unfolded proteins largely in the endoplasmic reticulum (ER).
Sandhya Chipurupalli, Raja Ganesan, Giulia Martini, Luigi Mele, Alessio Reggio, Marianna Esposito, Elango Kannan, Vigneshwaran Namasivayam, Paolo Grumati, Vincenzo Desiderio, Nirmal Robinson   +10 more
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ER‐phagy Activation by AMFR Attenuates Cardiac Fibrosis Post‐Myocardial Infarction via mTORC1 Pathway [PDF]

Advanced Science
Progressive cardiac fibrosis post myocardial infarction (MI) drives pathological remodeling and heart failure, yet the role of endoplasmic reticulum‐selective autophagy (ER‐phagy) in this process remains unclear. Autocrine Motility Factor Receptor (AMFR)
Zhixiang Wang, Kaifan Niu, Wei Liu, Xinyun Wang, Boshen Yang, Taixi Li, Yizhi Chen, Yuanyuan Jin, Yu Chen, Yangyi Lin, Xian Jin   +10 more
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FAM134B-mediated endoplasmic reticulum autophagy protects against cisplatin-induced spiral ganglion neuron damage [PDF]

Frontiers in Pharmacology
IntroductionCochlear spiral ganglion neurons (SGNs) could be damaged by ototoxic drug, cisplatin (Cis), during which process autophagy was involved. FAM134B, the first detected endoplasmic reticulum autophagy (ER-phagy) receptor, plays an important part ...
Fan Wang, Yue Xu, Yajie Wang, Qian Liu, Yanan Li, Weiwei Zhang, Huiming Nong, Junhong Zhang, Hao Zhao, Huaqian Yang, Lingchuan Guo, Jianfeng Li, Jianfeng Li, Hong Li, Qianqian Yang   +14 more
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The ER-phagy receptor FAM134B is targeted by Salmonella Typhimurium to promote infection [PDF]

Nature Communications
Macroautophagy/autophagy is a key catabolic-recycling pathway that can selectively target damaged organelles or invading pathogens for degradation. The selective autophagic degradation of the endoplasmic reticulum (hereafter referred to as ER-phagy) is a
Damián Gatica, Reham M. Alsaadi, Rayan El Hamra, Boran Li, Rudolf Mueller, Makoto Miyazaki, Qiming Sun, Subash Sad, Ryan C. Russell   +8 more
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Loss of FAM134B increased endoplasmic reticulum stress and induced cell autophagy in breast cancer [PDF]

Frontiers in Immunology
ObjectiveBreast cancer is a leading cause of cancer-related mortality, and the most prevalent malignant neoplasm amongst women worldwide. This study aimed to explore the role of FAM134B in breast cancer progression.MethodsThe correlation between FAM134B ...
Zhaoqi Zhang, Yan Fang, Zhibing Qiu, Shuning Ding, Deyue Liu, Wanqiu Huang, Li Zhu   +6 more
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An Inversion Disrupting FAM134B Is Associated with Sensory Neuropathy in the Border Collie Dog Breed [PDF]

G3: Genes, Genomes, Genetics, 2016
Sensory neuropathy in the Border Collie is a severe neurological disorder caused by the degeneration of sensory and, to a lesser extent, motor nerve cells with clinical signs starting between 2 and 7 months of age.
Oliver P. Forman, Rebekkah J. Hitti, Louise Pettitt, Christopher A. Jenkins, Dennis P. O’Brien, G. Diane Shelton, Luisa De Risio, Rodrigo Gutierrez Quintana, Elsa Beltran, Cathryn Mellersh   +9 more
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The multiple roles of Ggt1-Cre in the generation of transgenic mice [PDF]

Cellular & Molecular Biology Letters
The Cre/loxP system continues to serve as a well-established and widely adopted strategy for generating conditional gene knockout or knock-in mouse models, facilitating precise genetic manipulations.
Ze-Sen Feng, Jie Luo, Xiao-Cui Chen, Ping-Ping Zhao, Shi-Tong Qiu, Chun-Yu Wu, Xiao-Rong Huang, Bing-Chun Sun, Xiao-Jun Guo, Zhen-Nan Ye, Chen Yang, Hua-Feng Liu, Ji-Xin Tang   +12 more
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AMFR-mediated ER-phagy regulation and therapeutic targeting in osteosarcoma: a multifunctional nanoplatform strategy [PDF]

Journal of Nanobiotechnology
This work explores how Autocrine Motility Factor Receptor (AMFR)-driven ubiquitination of Family with Sequence Similarity 134 Member B (FAM134B) in hypoxia adaptation and endoplasmic reticulum-selective autophagy (ER-phagy) in osteosarcoma (OS), aiming ...
Qirui Zhao, Xiaoqing Lu, Tongtong Xu, Zixuan Gao, Linjia Peng, Binyu Zhu, Weicheng Wang, Zhigang Liu, Guangjie Yang, Hui Zhao, Zhiming Song, Qiankun Lou, Jiaming Li, Zhiguang Ren, Zhe Yu, de la Fuente Jesus M, Daxiang Cui   +16 more
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Association Between FAM134B and Diabetic Peripheral Neuropathy in Type 2 Diabetes: A Double-Center Case-Control Study [PDF]

Diabetes, Metabolic Syndrome and Obesity
Xingyun Hu,1,* Jie Peng,2,* Qingxian Li,3 Yuying Chen,4 Yingjuan Zeng,5 Peishan Li,4 Chuan Yang4 1Department of General Practice, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China; 2Department of ...
Hu X, Peng J, Li Q, Chen Y, Zeng Y, Li P, Yang C   +6 more
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