Results 101 to 110 of about 4,211 (172)
Two mixed breed dogs with sensory neuropathy are homozygous for an inversion disrupting FAM134B previously identified in Border Collies [PDF]
, 2018 Two unrelated 8-month-old male mixed breed dogs were presented for evaluation of progressive ataxia, knuckling, and lack of pain perception in the distal limbs. Because of the similarity in age of onset, progression, and clinical findings with previously
Amengual-Batle, Pablo +6 more
core +1 more source
ESCRT machinery mediates selective microautophagy of endoplasmic reticulum in yeast
, 2019 ER-phagy, the selective autophagy of endoplasmic reticulum (ER), safeguards organelle homeostasis by eliminating misfolded proteins and regulating ER size. ER-phagy can occur by macroautophagic and microautophagic mechanisms.
Charlotta Funaya +12 more
core +2 more sources
Clearance Pathways for α‐Synuclein in Parkinson's Disease
Journal of Neurochemistry, Volume 169, Issue 6, June 2025.α‐syn degradation in neurons and glia in PD. (A) Monomeric or prefibrillar α‐syn is eliminated in neurons via the UPS pathway. Under pathological conditions, fibrillar α‐syn is targeted by autophagy, while CMA is the major route for monomeric or prefibrillar α‐syn.
Margaret S. Ho
wiley +1 more source
Plasma proteome mediate the impact of PM2.5 on stroke: A 2-step Mendelian randomization study
Ecotoxicology and Environmental SafetyThe objectives of this study were to measure the mediation effect of plasma proteins and to clarify their mediating role in the relationship between stroke risk and particulate matter 2.5 (PM2.5) exposure.
Huajie Yang +6 more
doaj +1 more source
ID: 1036 FAM134B, a new player in human colorectal cancer pathogenesis
Biomedical Research and Therapy, 2017 Background: FAM134B (family with sequence similarity 134, member B) is a relatively new player in many human diseases including cancers. In colorectal carcinomas, FAM134B plays important role in the pathogenesis and associated with biological aggressiveness of the disease.
Alfred K-Y Lam +2 more
openaire +2 more sources
Exploration of the Prognostic Markers of Multiple Myeloma Based on Cuproptosis‐Related Genes
Cancer Reports, Volume 8, Issue 3, March 2025.ABSTRACT Background The investigation of cuproptosis in relation to tumor development has been limited, particularly in multiple myeloma (MM), indicating the need for further research. Our study aimed to examine the impact of cuproptosis‐related genes (CRGs) on the prognosis of MM.
Xiao‐Han Gao +6 more
wiley +1 more source
Lysosomal degradation of ER client proteins by ER-phagy and related pathways [PDF]
The endoplasmic reticulum (ER) is a major site of cellular protein synthesis. Degradation of overabundant, misfolded, aggregating or unwanted proteins is required to maintain proteostasis and avoid the deleterious consequences of aberrant protein ...
Jimenez-Moreno, Natalia +2 more
core +1 more source
Emerging Principles of Selective ER Autophagy [PDF]
, 2019 The endoplasmic reticulum (ER) is a fundamental organelle in cellular metabolism and signal transduction. It is subject to complex, dynamic sculpting of morphology and composition. Degradation of ER content has an important role to play here.
Wilkinson, Simon
core +1 more source
小胞体選択的オートファジーの新規レセプターTEX264の同定 [PDF]
, 2019 東京大学The University of Tokyo博士(医学)学位の種別: 課程博士審査委員会委員 : （主査）東京大学教授 南學 正臣, 東京大学教授 村上 誠, 東京大学特任教授 清水 孝雄, 東京大学准教授 大庭 伸介, 東京大学特任准教授 岩部 美紀doctoral ...
Chino, Haruka, 千野, 遥
core +1 more source
AutophagyThe endoplasmic reticulum (ER) serves as a hub for various cellular processes, and maintaining ER homeostasis is essential for cell function. Reticulophagy is a selective process that removes impaired ER subdomains through autophagy-mediatedlysosomal degradation.
Man Zhang +7 more
openaire +2 more sources