Results 161 to 170 of about 4,211 (172)

FAM134B improves preadipocytes differentiation by enhancing mitophagy

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2019
Family with Sequence Similarity 134, Member B (FAM134B) is a protein that known to be necessary for the long-term survival of nociceptive and autonomic ganglion neurons. Recent work has exhibited that FAM134B plays a pivotal role in autophagy-mediated turnover of endoplasmic reticulum (ER) membranes, tumor inhibition and lipid homeostasis.
Min, Cai, Jing, Zhao, Qing, Liu, Xinxia, Wang, Yizhen, Wang   +4 more
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Targeting FAM134B-mediated reticulophagy activates sorafenib-induced ferroptosis in hepatocellular carcinoma

Biochemical and Biophysical Research Communications, 2022
Ferroptosis is a kind of cell death closely related to selective autophagy, such as ferritinophagy, lipophagy, clockophagy and chaperone-mediated autophagy. However, the role of reticulophagy, which specifically degrades endoplasmic reticulum (ER) fragments (also known as ER-phagy), in ferroptosis regulation is still unclear.
Zhiqian, Liu, Changlin, Ma, Qi, Wang, Hao, Yang, Zhihua, Lu, Tao, Bi, Zongzhen, Xu, Tao, Li, Ling, Zhang, Yajie, Zhang, Jingfang, Liu, Xiaoqing, Wei, Jie, Li   +12 more
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The pivotal role of FAM134B in selective ER-phagy and diseases

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2022
FAM134B is also known as the reticulophagy regulator 1 (RETREG1) or JK-1. FAM134B consists of two long hydrophobic fragments with a reticulon-homology domain, an N-terminal cytoplasmic domain, and a C-terminal cytoplasmic domain. FAM134B plays an important role in regulating selective ER-phagy, and is related to the occurrence and development of many ...
Wei, Chen, Hui, Mao, Linxi, Chen, Lanfang, Li   +3 more
openaire   +2 more sources

The roles of JK-1 (FAM134B) expressions in colorectal cancer

Experimental Cell Research, 2014
The aims of the present study are to investigate the clinicopathological correlations of JK-1(FAM134B) expression and its relationship to carcinogenesis in a colorectal adenoma-adenocarcinoma model. JK-1(FAM134B) protein expression was studied in a colon cancer cell line by Western blot and immunocytochemistry. JK-1(FAM134B) expression profiles at mRNA
Kasem, Kais, Gopalan, Vinod, Salajegheh, Ali, Lu, Cu-Tai, Smith, Robert, Lam, Alfred   +5 more
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Identification of sensory dysfunction and nervous structure changes in Fam134b knockout mice

Neurological Research, 2022
Mutation in human FAM134B gene has been implicated in hereditary sensory and autonomic neuropathy type IIB. We aimed to knock out Fam134b in mice and explored its phenotypes to determine whether the genetic impairments and behavioral changes can mirror manifestations noted in humans.We used CRISPR/Cas9 technology to knockout the Fam134b gene in the ...
Binghao, Chen, Xingyun, Hu, Meiling, Chen, Yuying, Chen, Li, Yan, Gang, Zeng, Chuan, Wang, Lixuan, Liu, Chuan, Yang, Weidong, Song   +9 more
openaire   +2 more sources

FAM134B promotes adipogenesis by increasing vesicular activity in porcine and 3T3-L1 adipocytes

Biological Chemistry, 2018
Abstract Family with sequence similarity 134, Member B (FAM134B), is a cis-Golgi transmembrane protein that is known to be necessary for the long-term survival of nociceptive and autonomic ganglion neurons. Recent work has shown that FAM134B plays a pivotal role in autophagy-mediated turnover of endoplasmic reticulum (ER) membranes ...
Min, Cai, Jin, Chen, Caihua, Yu, Lingling, Xi, Qin, Jiang, Yizhen, Wang, Xinxia, Wang   +6 more
openaire   +2 more sources

Mutations in FAM134B, encoding a newly identified Golgi protein, cause severe sensory and autonomic neuropathy

Nature Genetics, 2009
Hereditary sensory and autonomic neuropathy type II (HSAN II) leads to severe mutilations because of impaired nociception and autonomic dysfunction. Here we show that loss-of-function mutations in FAM134B, encoding a newly identified cis-Golgi protein, cause HSAN II.
Kurth, Ingo, Pamminger, Torsten, Hennings, J. Christopher, Soehendra, Désirée, Huebner, Antje K., Rotthier, Annelies, Baets, Jonathan, Senderek, Jan, Topaloglu, Haluk, Farrell, Sandra A., Nürnberg, Gudrun, Nürnberg, Gudrun, De Jonghe, Peter, Gal, Andreas, Kaether, Christoph, Timmerman, Vincent, Hübner, Christian A.   +16 more
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Mutation in FAM134B causing severe hereditary sensory neuropathy.

2012
Leinster
Murphy, Sinéad, Davidson, Gabrielle, Brandner, Sebastian, Houlden, Henry, Reilly, Mary   +4 more
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FAM134B Regulates Collagen I Processing and Fibrogenesis in Hepatic Stellate Cells

IUI ; Liver fibrosis is driven by the accumulation of scar tissue in response to liver injury. Activated hepatic stellate cells (HSCs) secrete fibrogenic proteins that deposit into the extracellular matrix, leading to fibrosis, cirrhosis, and liver failure.
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The endoplasmic reticulum protein FAM134B acts as a regulator of mitochondrial morphology

Journal of Cell Science
ABSTRACT The endoplasmic reticulum (ER) and mitochondria are known to affect myriad cellular mechanisms processes. More recently, dynamic association between them has been identified in different eukaryotes; these interactions vary in their composition and involvement in regulation of intracellular machineries.
Sebabrata Maity, Anwesha Dutta Gupta, Izaz Monir Kamal, Rajdeep Das, Rupsha Mondal, Arpit Tyagi, Deepak Sharma, Joy Chakraborty, Saikat Chakrabarti, Oishee Chakrabarti   +9 more
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