Results 11 to 20 of about 4,211 (172)

Fam134c and Fam134b shape axonal endoplasmic reticulum architecture in vivo [PDF]

EMBO Reports
Endoplasmic reticulum (ER) remodeling is vital for cellular organization. ER-phagy, a selective autophagy targeting ER, plays an important role in maintaining ER morphology and function. The FAM134 protein family, including FAM134A, FAM134B, and FAM134C,
Francescopaolo Iavarone, Marta Zaninello, Michela Perrone, Mariagrazia Monaco, Esther Barth, Felix Gaedke, Maria Teresa Pizzo, Giorgia Di Lorenzo, Vincenzo Desiderio, Eduardo Sommella, Fabrizio Merciai, Emanuela Salviati, Pietro Campiglia, Livio Luongo, Elvira De Leonibus, Elena Rugarli, Carmine Settembre   +16 more
doaj   +8 more sources

Two FAM134B isoforms differentially regulate ER dynamics during myogenesis [PDF]

The EMBO Journal
Endoplasmic reticulum (ER) plasticity and ER-phagy are intertwined processes essential for maintaining ER dynamics. We investigated the interplay between two isoforms of the ER-phagy receptor FAM134B in regulating ER remodeling in differentiating ...
Viviana Buonomo, Kateryna Lohachova, Alessio Reggio, Sara Cano-Franco, Michele Cillo, Lucia Santorelli, Rossella Venditti, Elena Polishchuk, Ivana Peluso, Lorene Brunello, Carmine Cirillo, Sara Petrosino, Malan Silva, Rossella De Cegli, Sabrina Di Bartolomeo, Cesare Gargioli, Paolo Swuec, Mirko Cortese, Alexandra Stolz, Ramachandra M Bhaskara, Paolo Grumati   +20 more
doaj   +7 more sources

Coordinated Role of Autophagy and ERAD in Maintaining Neuroendocrine Function by Preventing Prohormone Aggregation [PDF]

Advanced Science
Proteotoxicity induced by misfolded or aggregated proteins causes progressive neuronal damage. The endoplasmic reticulum (ER) protein quality control (ERQC) pathways are responsible for mitigating the accumulation of these misfolded or aggregated ...
Xuya Pan, Xing He, Su Wu, Na Xiong, Xinyu Hou, Heting Wang, Diane Somlo, Martin Spiess, Haiyang Wang, Jifeng Yang, Chunliang Li, Shasha Li, Wenbin Ma, Yanming Chen, Jun Cui, Ling Qi, Guojun Shi   +16 more
doaj   +3 more sources

FAM134B deletion exacerbates apoptosis and epithelial-to-mesenchymal transition in rat lungs exposed to hyperoxia [PDF]

iScience
Summary: Oxygen therapy is widely used in clinical practice; however, prolonged hyperoxia exposure may result in hyperoxic acute lung injury (HALI). In this study, we investigated the role of FAM134B in hyperoxia-induced apoptosis, cell proliferation ...
Hong Guo, Rong-Rong Huang, Shan-Shan Qu, Ying Yao, Su-Heng Chen, Shao-Li Ding, Yu-Lan Li   +6 more
doaj   +4 more sources

Elevated FAM134B expression induces radiation-sensitive in hepatocellular carcinoma

BMC Cancer, 2023
Background Previous studies have shown that Family with sequence similarity 134 member B (FAM134B) was involved in the occurrence and development of malignancy, however, the function and molecular mechanism of FAM134B in Hepatocellular Carcinoma (HCC ...
Binhui Xie, Yuankang Xie, Cuifu Fang, Baiyin Zhong, Rong Ye, Jianhong Zhang, Qingquan Liu, Heping Li   +7 more
doaj   +3 more sources

MiR-142-5p/FAM134B Axis Manipulates ER-Phagy to Control PRRSV Replication

Frontiers in Immunology, 2022
Porcine reproductive and respiratory syndrome virus (PRRSV) can replicate its RNA genome in endoplasmic reticulum (ER) and utilize ER to facilitate its assembly and maturation.
Kaifeng Guan, Qiuju Su, Kailin Kuang, Xiangge Meng, Xiang Zhou, Xiang Zhou, Bang Liu, Bang Liu, Bang Liu   +8 more
doaj   +3 more sources

Fecal microbiota transplantation ameliorates radiation-induced lung injury by reshaping gut metabolic homeostasis to activate FAM134B-mediated ER-phagy. [PDF]

PLoS Pathogens
Radiation-induced lung injury (RILI) is a serious complication of thoracic radiotherapy, with limited effective treatment options. This study demonstrates that fecal microbiota transplantation (FMT) confers protection against RILI through modulation of ...
Xiaoyu Pu, Bohao Liu, Lihua Dong, Meng Yuan, Shunzi Jin, Xin Jiang   +5 more
doaj   +2 more sources

MIT/TFE FACTORS CONTROL ER-PHAGY VIA TRANSCRIPTIONAL REGULATION OF FAM134B [PDF]

, 2022
Lysosomes are catabolic organelles devoted to the degradation of intracellular proteins and components. In addition, lysosomes are signalling hubs that orchestrate many intracellular responses.
IAVAZZO, MARIA
core   +2 more sources

AMFR-mediated Flavivirus NS2A ubiquitination subverts ER-phagy to augment viral pathogenicity [PDF]

Nature Communications
Flaviviruses strategically utilize the endoplasmic reticulum (ER) in their replication cycles. However, the role of ER autophagy (ER-phagy) in viral replication process remains poorly understood. Here, we reveal that prolonged Zika virus (ZIKV) infection
Linliang Zhang, Hongyun Wang, Chao Han, Qi Dong, Jie Yan, Weiwei Guo, Chao Shan, Wen Zhao, Pu Chen, Rui Huang, Ying Wu, Yu Chen, Yali Qin, Mingzhou Chen   +13 more
doaj   +2 more sources

ADP ribosylation factor-like GTPase 6-interacting protein 5 (ARL6IP5): a prenylated Rab acceptor protein 1 (PRA1) family protein that shapes the ER membrane and regulates ER-phagy [PDF]

Autophagy Reports
The prenylated Rab acceptor protein 1 (PRA1) domain is a conserved domain encompassing four transmembrane domains (TMDs). ARL6IP5 (ADP ribosylation factor-like GTPase 6-interacting protein 5) is a member of the PRA1 family and interacts with the ...
Yasunori Yamamoto, Toshiaki Sakisaka
doaj   +2 more sources