Results 21 to 30 of about 4,211 (172)

CNX:FAM134B-driven ERLAD of ATZ polymers proceeds via enhanced formation of VAPA:ORP1L:RAB7 contact sites between ER and endolysosomes [PDF]

Autophagy Reports
Membrane contact sites (MCS) between organelles maintain the proximity required for controlled exchange of small molecules and ions yet preventing fusion events that would compromise organelles’ identity and integrity.
Elisa Fasana, Ilaria Fregno, Maurizio Molinari   +2 more
doaj   +2 more sources

RETREG1/FAM134B-mediated micro-ER-phagy in the retrovirus–SERINC5 arms race [PDF]

Autophagy Reports
Reticulophagy regulator 1 (RETREG1)/Family with sequence similarity 134 member B (FAM134B) is a selective endoplasmic reticulum (ER)-phagy receptor that mediates starvation-induced macro-ER-phagy, but whether it participates in other pathways mediating ...
Jim Maurice Camilleri, Iqbal Ahmad, Jing Zhang, Sunan Li, Yong-Hui Zheng   +4 more
doaj   +2 more sources

ER-phagy mediates the anti-tumoral synergism between HDAC inhibition and chemotherapy [PDF]

Cell Communication and Signaling
Background Histone deacetylase inhibitors (HDACi) are clinically approved drugs for the treatment of hematological malignancies synergizing with chemotherapy.
Felix J. Gössl, Pierfrancesco Polo, Frederik Helmprobst, André Menzenbach, Alexander Visekruna, Thomas M. Gress, Till Adhikary, Matthias Lauth   +7 more
doaj   +2 more sources

Qingre Huoxue decoction attenuates myocardial ischemia‒reperfusion injury by regulating the autophagy‒endoplasmic reticulum stress axis via FAM134B-mediated ER-phagy [PDF]

Frontiers in Pharmacology
BackgroundAutophagy‒endoplasmic reticulum (ER) stress axis dysregulation is linked to myocardial ischemia‒reperfusion injury (MIRI), which counteracts the benefits of acute myocardial infarction (AMI) reperfusion therapy.
Rui Li, Rui Li, Jiechun Zhang, Shuliang Ji, Junfeng Fang, Junfeng Fang, Xiaodong Ji, Xiaodong Ji, Yanping Zeng, Yanping Zeng, Nan Liu, Nan Liu, Wei Wu, Wei Wu, Shiyi Liu, Shiyi Liu   +15 more
doaj   +2 more sources

Curvature induction and membrane remodeling by FAM134B reticulon homology domain assist selective ER-phagy [PDF]

Nature Communications, 2019
FAM134B/RETREG1 is a selective ER-phagy receptor that regulates the size and shape of the endoplasmic reticulum. Here authors use molecular modeling and molecular dynamics simulations to assemble a structural model for the reticulon-homology domain of ...
Ramachandra M. Bhaskara, Paolo Grumati, Javier Garcia-Pardo, Sissy Kalayil, Adriana Covarrubias-Pinto, Wenbo Chen, Mikhail Kudryashev, Ivan Dikic, Gerhard Hummer   +8 more
doaj   +6 more sources

Autophagy cargo profiles in skeletal muscle during starvation and exercise [PDF]

Autophagy Reports
Autophagy is a cellular process to clear unwanted and dysfunctional cellular cargoes, which are sequestered in autophagosomes before their delivery to lysosomes for degradation.
Mohd Farhan, Shangze Lyu, Trezze P. Nguyen, Dakai Zhang, Hong Liang, Yong Zhou, Yu A. An, Jun Wang, Hongyuan Yang, Guangwei Du, Yang Liu   +10 more
doaj   +2 more sources

Intrinsically disordered region amplifies membrane remodeling to augment selective ER-phagy. [PDF]

Proc Natl Acad Sci U S A
Intrinsically disordered regions (IDRs) play a pivotal role in organellar remodeling. They transduce signals across membranes, scaffold signaling complexes, and mediate vesicular traffic.
Poveda-Cuevas SA, Lohachova K, Markusic B, Dikic I, Hummer G, Bhaskara RM.   +5 more
europepmc   +3 more sources

ATG9A regulates proteostasis through reticulophagy receptors FAM134B and SEC62 and folding chaperones CALR and HSPB1 [PDF]

iScience, 2021
Summary: The acetylation of ATG9A within the endoplasmic reticulum (ER) lumen regulates the induction of reticulophagy. ER acetylation is ensured by AT-1/SLC33A1, a membrane transporter that maintains the cytosol-to-ER flux of acetyl-CoA.
Brendan K. Sheehan, Nicola S. Orefice, Yajing Peng, Samantha L. Shapiro, Luigi Puglielli   +4 more
doaj   +3 more sources

Sestrin2 drives ER-phagy in response to protein misfolding. [PDF]

Dev Cell
Protein biogenesis within the endoplasmic reticulum (ER) is crucial for organismal function. Errors during protein folding necessitate the removal of faulty products.
De Leonibus C, Maddaluno M, Ferriero R, Besio R, Cinque L, Lim PJ, Palma A, De Cegli R, Gagliotta S, Montefusco S, Iavazzo M, Rohrbach M, Giunta C, Polishchuk E, Medina DL, Di Bernardo D, Forlino A, Piccolo P, Settembre C.   +18 more
europepmc   +4 more sources

FAM134B-mediated ER-phagy regulates ER-mitochondria interaction through MAMs

Acta Biochimica et Biophysica Sinica, 2021
Chen Wei, Ouyang Xueqian, Chen Linxi, Li Lanfang   +3 more
doaj   +2 more sources