Results 31 to 40 of about 4,211 (172)

FAM134B-RHD Protein Clustering Drives Spontaneous Budding of Asymmetric Membranes [PDF]

The Journal of Physical Chemistry Letters, 2021
AbstractLiving cells constantly remodel the shape of their lipid membranes. In the endo-plasmic reticulum (ER), the reticulon homology domain (RHD) of the reticulophagy regulator 1 (RETR1/FAM134B) forms dense autophagic puncta that are associated with membrane removal by ER-phagy.
Marc Siggel, Ramachandra M. Bhaskara, Melanie K. Moesser, Ivan D̵ikić, Gerhard Hummer   +4 more
openaire   +6 more sources

Critical roles of FAM134B in ER-phagy and diseases [PDF]

Cell Death & Disease, 2020
AbstractFAM134B (also called JK-1, RETREG1), a member of the family with sequence similarity 134, was originally discovered as an oncogene in esophageal squamous cell carcinoma. However, its most famous function is that of an ER-phagy-regulating receptor.
Mo, Jie, Chen, Jin, Zhang, Bixiang
openaire   +2 more sources

A RETREG1/FAM134B isoform switch regulates reticulophagy during myogenesis. [PDF]

Autophagy
During skeletal muscle development, the sarcoplasmic reticulum forms through the homotypic fusion of ER membranes from individual myoblasts. This involves significant ER remodeling, characterized by an overhaul of its proteomic landscape and the activation of reticulophagy.
Buonomo V, Cillo M, Grumati P.
europepmc   +4 more sources

Manipulation of the Unfolded Protein Response by Intracellular Bacterial Pathogens: Mechanisms of ER Hijacking and Therapeutic Implications. [PDF]

FASEB J
This review illustrates how intracellular bacterial pathogens—such as Brucella, Mycobacterium tuberculosis, and Legionella—secrete effector proteins that specifically target the IRE1α, PERK, and ATF6 branches of the unfolded protein response (UPR) to hijack ER stress signaling.
Dai E, Sun D, Zhao Y, Zhang M, Wu Y, Ding J.   +5 more
europepmc   +2 more sources

An N-terminal–truncated isoform of FAM134B (FAM134B-2) regulates starvation-induced hepatic selective ER-phagy [PDF]

Life Science Alliance, 2019
Autophagy is a conserved system that adapts to nutrient starvation, after which proteins and organelles are degraded to recycle amino acids in response to starvation. Recently, the ER was added to the list of targets of autophagic degradation. Autophagic degradation pathways of bulk ER and the specific proteins sorted through the ER are considered key ...
Shohei Kohno, Yuji Shiozaki, Audrey L Keenan, Shinobu Miyazaki-Anzai, Makoto Miyazaki   +4 more
openaire   +2 more sources

Heteromeric clusters of ubiquitinated ER-shaping proteins drive ER-phagy [PDF]

, 2023
Membrane-shaping proteins characterized by reticulon homology domains play an important part in the dynamic remodelling of the endoplasmic reticulum (ER). An example of such a protein is FAM134B, which can bind LC3 proteins and mediate the degradation of
Bhaskara, R. , Bock, A., Bocker, H., Covarrubias-Pinto, A., Dikić, I., Foronda, H., Franzka, P., Fu, Y., Gleeson, J., González, A., Hoffmann, M., Hummer, G. , Hübner, C., Katona, I., Kessels, M., Koch, N., Kurth, I., Liebmann, L., Mari, M., Qualmann, B., Reggiori, F., Seemann, E., Weis, J.   +22 more
core   +5 more sources

Beating the ER: novel insights into FAM134B function and regulation [PDF]

The EMBO Journal, 2020
To maintain cellular homeostasis, the endoplasmic reticulum (ER) necessitates a continuous removal of ER fragments via a selective, receptor-mediated, form of autophagy known as ER-phagy. In this issue of The EMBO Journal, Jiang et al (2020) shed light on how the best characterized autophagy receptor FAM134B mediates ER membrane fragmentation, the ...
Chiara De Leonibus, Laura Cinque, Carmine Settembre   +2 more
openaire   +4 more sources

FAM134B in Cellular Homeostasis: Bridging Endoplasmic Reticulum-Phagy to Human Diseases. [PDF]

Int J Biol Sci
Chen N, Yang JQ, Tong S, Xu L, Dong N, Wu Y, Li YX, Yao RQ, Yao YM.   +8 more
europepmc   +3 more sources

Novel FAM134B mutations and their clinicopathological significance in colorectal cancer [PDF]

Human Genetics, 2017
FAM134B is a putative tumour suppressor gene and no mutations in FAM134B have been reported in colorectal cancer (CRC) to date. This study aims to identify FAM134B mutation sites and the clinicopathological significance of the gene in patients with CRC. Eighty-eight colorectal cancers were studied for FAM134B mutations by Sanger sequencing.
Islam, Farhadul, Gopalan, Vinod, Wahab, Riajul, Lee, Katherine Ting-wei, Haque, Md. Hakimul, Mamoori, Afraa, Lu, Cu-Tai, Smith, Robert, Lam, Alfred   +8 more
openaire   +3 more sources

The function of ER-phagy receptors is regulated through phosphorylation-dependent ubiquitination pathways

Nature Communications, 2023
Selective autophagy of the endoplasmic reticulum (ER), known as ER-phagy, is an important regulator of ER remodeling and essential to maintain cellular homeostasis during environmental changes.
Rayene Berkane, Hung Ho-Xuan, Marius Glogger, Pablo Sanz-Martinez, Lorène Brunello, Tristan Glaesner, Santosh Kumar Kuncha, Katharina Holzhüter, Sara Cano-Franco, Viviana Buonomo, Paloma Cabrerizo-Poveda, Ashwin Balakrishnan, Georg Tascher, Koraljka Husnjak, Thomas Juretschke, Mohit Misra, Alexis González, Volker Dötsch, Paolo Grumati, Mike Heilemann, Alexandra Stolz   +20 more
doaj   +1 more source