FAM134B-mediated endoplasmic reticulum autophagy protects against sepsis myocardial injury in mice
Aging, 2021 Reticulophagy regulator 1 (RETEG1, also known as FAM134B) plays a crucial role in endoplasmic reticulum autophagy. We aimed to explore the effect of FAM134B-mediated endoplasmic reticulum autophagy in sepsis myocardial injury in mice. Sepsis myocardial injury mice were established via cecal ligation and puncture procedures.
Li, Tong +4 more
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FEBS Open Bio, 2022 The mammalian Atg8 family (Atg8s proteins) consists of two subfamilies: GABARAP and LC3. All members can bind to the LC3‐interacting region (LIR) or Atg8‐interacting motif and participate in multiple steps of autophagy.
Junfeng Zhao, Zhiwei Li, Jianchao Li
doaj +1 more source
Cell biology: Receptors for selective recycling. [PDF]
, 2015 This is the author accepted manuscript. The final version is available from Nature at http://www.nature.com/nature/journal/vaop/ncurrent/full/nature14532 ...
Rubinsztein, David C
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PACS-2 deficiency aggravates tubular injury in diabetic kidney disease by inhibiting ER-phagy
Cell Death and Disease, 2023 Autophagy of endoplasmic reticulum (ER-phagy) selectively removes damaged ER through autophagy-lysosome pathway, acting as an adaptive mechanism to alleviate ER stress and restore ER homeostasis.
Jinfei Yang +16 more
doaj +1 more source
Beyond self-eating: The control of nonautophagic functions and signaling pathways by autophagy-related proteins. [PDF]
, 2017 The identification of conserved autophagy-related proteins (ATGs) that mediate bulk degradation of cytosolic material laid the foundation for breakthroughs linking autophagy to a litany of physiological processes and disease conditions.
Cadwell, Ken, Debnath, Jayanta
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Detection of regional DNA methylation using DNA-graphene affinity interactions [PDF]
, 2016 We report a new multiplexed strategy for the electrochemical detection of regional DNA methylation across multiple regions. Using the sequence dependent affinity of bisulfite treated DNA towards gold surfaces, the method integrates the high sensitivity ...
Carrascosa, Laura G. +9 more
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Phosphorylation of FAM134C by CK2 controls starvation-induced ER-phagy. [PDF]
, 2022 Selective degradation of the endoplasmic reticulum (ER) via autophagy (ER-phagy) is initiated by ER-phagy receptors, which facilitate the incorporation of ER fragments into autophagosomes.
Aureli, Simone +20 more
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CCPG1 Is a Non-canonical Autophagy Cargo Receptor Essential for ER-Phagy and Pancreatic ER Proteostasis [PDF]
, 2018 Mechanisms of selective autophagy of the ER, known as ER-phagy, require molecular delineation, particularly in vivo. It is unclear how these events control ER proteostasis and cellular health.
Adamson +87 more
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Identification of Novel FAM134B (JK1) Mutations in Oesophageal Squamous Cell Carcinoma [PDF]
Scientific Reports, 2016 AbstractMutation of FAM134B (Family with Sequence Similarity 134, Member B) leading to loss of function of its encoded Golgi protein and has been reported induce apoptosis in neurological disorders. FAM134B mutation is still unexplored in cancer. Herein, we studied the DNA copy number variation and novel mutation sites of FAM134B in a large cohort of ...
Haque, Md Hakimul +5 more
openaire +3 more sources
Transgenic expression of human glial cell line-derived neurotrophic factor (hGDNF) from integration-deficient lentiviral vectors is neuroprotective in a rodent model of Parkinson's disease [PDF]
, 2014 Standard integration-proficient lentiviral vectors (IPLVs) are effective at much lower doses than other vector systems and have shown promise for gene therapy of Parkinson's disease (PD). Their main drawback is the risk of insertional mutagenesis.
Christof von Kalle +7 more
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