Results 51 to 60 of about 4,211 (172)
Genetic aberrations in macroautophagy genes leading to diseases [PDF]
, 2018 The catabolic process of macroautophagy, through the rapid degradation of unwanted cellular components, is involved in a multitude of cellular and organismal functions that are essential to maintain homeostasis.
Klionsky, Daniel J +2 more
core +1 more source
Molecular Oncology, 2019 Fam134b (JK‐1, RETREG1) was first identified as an oncogene in esophageal squamous cell carcinoma. However, the roles of FAM134B during tumorigenesis of hepatocellular carcinoma (HCC) and in epithelial‐to‐mesenchymal transition (EMT) were previously ...
Zhao‐qi Zhang +12 more
doaj +1 more source
Structural and Functional analysis of the GABARAP interaction motif (GIM) [PDF]
, 2016 © 2017 The Authors. Published under the terms of the CC BY 4.0 license. Through the canonical LC3 interaction motif (LIR), [W/F/Y]-X 1 -X 2 -[I/L/V], protein complexes are recruited to autophagosomes to perform their functions as either autophagy ...
Alexander Law +12 more
core +5 more sources
Scans for signatures of selection in Russian cattle breed genomes reveal new candidate genes for environmental adaptation and acclimation [PDF]
, 2018 Domestication and selective breeding has resulted in over 1000 extant cattle breeds. Many of these breeds do not excel in important traits but are adapted to local environments.
A Talenti +108 more
core +5 more sources
MiT/TFE factors control ER-phagy via transcriptional regulation of FAM134B [PDF]
, 2020 Lysosomal degradation of the endoplasmic reticulum (ER) via autophagy (ER-phagy) is emerging as a critical regulator of cell homeostasis and function. The recent identification ofER-phagy receptors has shed light on the molecular mechanisms underlining ...
Ballabio A +23 more
core +1 more source
Cell Death and Disease, 2022 Cardiomyocyte pyroptosis and apoptosis play a vital role in the pathophysiology of several cardiovascular diseases. Our recent study revealed that gasdermin D (GSDMD) can promote myocardial I/R injury via the caspase-11/GSDMD pathway.
Ya’nan Qu +12 more
doaj +1 more source
A Pyrido-Quinoxaline Derivative That Downregulates Reticulon 3 Protein Exhibits Potent Antiviral Activity Against Zika Virus. [PDF]
J Med VirolABSTRACT In the wake of the COVID‐19 pandemic, awareness of emerging pathogens has significantly increased, prompting greater investment in research and preparedness. In this context, arboviral diseases are recognized as unmet medical challenges due to their rapid spread. Notably, the geographical range of several flaviviral diseases is expanding: Zika
Plicanti E +11 more
europepmc +2 more sources
Scientific Reports, 2017 Despite the excellent diagnostic applications of the current conventional immunoassay methods such as ELISA, immunostaining and Western blot for FAM134B detection, they are laborious, expensive and required a long turnaround time.
Farhadul Islam +7 more
doaj +1 more source
Dengue and Zika viruses subvert reticulophagy by NS2B3-mediated cleavage of FAM134B [PDF]
Autophagy, 2017 The endoplasmic reticulum (ER) is exploited by several diverse viruses during their infectious life cycles. Flaviviruses, including dengue virus (DENV) and Zika virus (ZIKV), utilize the ER as a source of membranes to establish their replication organelles and to facilitate their assembly and eventual maturation along the secretory pathway. To maintain
Nicholas J, Lennemann, Carolyn B, Coyne
openaire +2 more sources
A regulatory circuit comprising the CBP and SIRT7 regulates FAM134B-mediated ER-phagy
Journal of Cell Biology, 2023 Macroautophagy (autophagy) utilizes a serial of receptors to specifically recognize and degrade autophagy cargoes, including damaged organelles, to maintain cellular homeostasis. Upstream signals spatiotemporally regulate the biological functions of selective autophagy receptors through protein post-translational modifications (PTM) such as ...
Xinyi Wang +16 more
openaire +2 more sources