Results 61 to 70 of about 4,211 (172)

Corrigendum to: Excessive ER-phagy mediated by FAM134B contributes to trophoblast cell mitochondrial dysfunction in preeclampsia [PDF]

Acta Biochimica et Biophysica Sinica
Wang Andi, Li Zhuo, Zhang Dan, Chen Chang, Zhang Hua   +4 more
doaj   +2 more sources

Host-pathogen interactions and subversion of autophagy [PDF]

, 2017
Macroautophagy (“autophagy”), is the process by which cells can form a double membraned vesicle that encapsulates material to be degraded by the lysosome.
Alemu, Ali, Axe, Barnett, Baxt, Beale, Birmingham, Campbell, Cao, Case, Choy, David G. McEwan, de Jong, Diao, Dortet, Gaillard, Ganley, Gannage, Genau, Gutierrez, Habisov, Hailey, Hamasaki, Hanada, Hegedus, Horenkamp, Huett, Ikeda, Ikeda, Itakura, Jacomin, James T. Murray, Jennings, Joachim, Jon D. Lane, Khaminets, Kim, Kirisako, Kirkin, Kraft, Kreibich, Krick, Kuma, Kwon, Kyei, Lety, Li, Liu, Liu, Lu, Lystad, Maejima, Manzanillo, Matsunaga, Matsunaga, McEwan, Mira, Mohrluder, Moreau, Mostowy, Nakagawa, Nakatogawa, Newman, Noad, Noda, Noda, Novak, Ogawa, Olsvik, Pankiv, Pankiv, Petkova, Polson, Popovic, Ravikumar, Richetta, Rogov, Rogov, Russell, Schnaith, Slobodkin, Stolz, Taguchi-Atarashi, Takats, Thurston, Thurston, Thurston, Tsuboyama, Tumbarello, van der Vaart, van Wijk, van Wijk, Verlhac, Viktor I. Korolchuk, von Muhlinen, Watson, Weidberg, Wild, Yang, Yang, Yoshikawa, Yu, Zheng, Zhong, Zhou   +104 more
core   +2 more sources

Ubiquitination regulates ER-phagy and remodelling of endoplasmic reticulum [PDF]

, 2023
The endoplasmic reticulum (ER) undergoes continuous remodelling via a selective autophagy pathway, known as ER-phagy1. ER-phagy receptors have a central role in this process2, but the regulatory mechanism remains largely unknown.
Balakrishnan, A., Bhaskara, R. , Bräuning, B., Covarrubias-Pinto, A., Dikić, I., Dötsch, V., Glogger, M., González, A., Heilemann, M., Hoffmann, M., Hummer, G. , Hübner, C., Kessels, M., Kuncha, S., Misra, M., Qualmann, B., Schulman, B., Seemann, E., Xavier, A.   +18 more
core   +1 more source

Genome-wide association study of peripheral neuropathy with D-drug-containing regimens in AIDS Clinical Trials Group protocol 384. [PDF]

, 2014
Stavudine (d4T) was, until recently, one of the most widely prescribed antiretroviral drugs worldwide. While there has been a major shift away from d4T use in resource-limited countries, a large number of patients have previously received (or continue to
Clifford, D.B., Haas, D.W., Johnson, D.H., Leger, P.D., Li, J., McLaren, P.J., Robbins, G.K., Shafer, R.W.   +7 more
core   +1 more source

RTN4B interacting protein FAM134C promotes ER membrane curvature and has a functional role in autophagy [PDF]

, 2021
The endoplasmic reticulum (ER) is composed of a controlled ratio of sheets and tubules, which are maintained by several proteins with multiple functions.
Belevich, Ilya, Jokitalo, Eija, Kumar, Darshan, Lak, Behnam, Suntio, Taina, Varjosalo, Markku, Vartiainen, Aki, Vartiainen, Maria, Vihinen, Helena, Viita, Tiina, Xiaonan, Liu   +10 more
core   +1 more source

O-GlcNAc transferase regulates intervertebral disc degeneration by targeting FAM134B-mediated ER-phagy

Experimental & Molecular Medicine, 2022
AbstractBoth O-linked β-N-acetylglucosaminylation (O-GlcNAcylation) and endoplasmic reticulum-phagy (ER-phagy) are well-characterized conserved adaptive regulatory mechanisms that maintain cellular homeostasis and function in response to various stress conditions.
Rongjin Luo, Gaocai Li, Weifei Zhang, Huaizhen Liang, Saideng Lu, Jason Pui Yin Cheung, Teng Zhang, Ji Tu, Hui Liu, Zhiwei Liao, Wencan Ke, Bingjin Wang, Yu Song, Cao Yang   +13 more
openaire   +2 more sources

Identification of Tumor Antigens and Immune Subtypes of Malignant Mesothelioma for mRNA Vaccine Development

Vaccines, 2022
Background: mRNA-based cancer vaccines have been considered a promising anticancer therapeutic approach against various cancers, yet their efficacy for malignant mesothelioma (MESO) is still not clear.
Shuhang Wang, Yuqi Yang, Lu Li, Peiwen Ma, Yale Jiang, Minghui Ge, Yue Yu, Huiyao Huang, Yuan Fang, Ning Jiang, Huilei Miao, Hao Guo, Linlin Yan, Yong Ren, Lichao Sun, Yan Zha, Ning Li   +16 more
doaj   +1 more source

Deep sequencing of small RNAs identifies canonical and non-canonical miRNA and endogenous siRNAs in mammalian somatic tissues [PDF]

, 2012
MicroRNAs (miRNAs) are small RNA molecules that regulate gene expression. They are characterized by specific maturation processes defined by canonical and non-canonical biogenic pathways.
Ambros, Babiarz, Babiarz, Bartel, Berezikov, Berezikov, Cheloufi, Chen, Chiang, Cifuentes, Denli, Ender, Flynt, Friedlander, Gregory, Griffiths-Jones, Han, Justin Stebbing, Kaneko, Karimi, Kuhn, Ladewig, Leandro Castellano, Lee, Leung, Okamura, Okamura, Piriyapongsa, Poethig, Ruby, Smalheiser, Tam, Valen, Watanabe, Westholm, Yang, Yang   +36 more
core   +1 more source

An N‐terminal truncated isoform of the ER‐phagy receptor FAM134B (FAM134B‐2) regulates starvation‐induced ER‐to‐lysosome protein degradation

The FASEB Journal, 2019
Autophagy is a conserved system that adapts to nutrient starvation, after which proteins and organelles are degraded to recycle amino acids in response to starvation. Recently, the endoplasmic reticulum (ER) was added to the list of targets of autophagic degradation.
Shinobu Miyazaki, Shohei Kohno, Yuji Shiozaki, Audrey Keenan, Makoto Miyazaki   +4 more
openaire   +1 more source

Hereditary sensory and autonomic neuropathy type 1 (HSANI) caused by a novel mutation in SPTLC2. [PDF]

, 2013
To describe the clinical and neurophysiologic phenotype of a family with hereditary sensory and autonomic neuropathy type 1 (HSANI) due to a novel mutation in SPTLC2 and to characterize the biochemical properties of this ...
Blake, J, Ernst, D, Hornemann, T, Houlden, H, Laurà, M, Liu, YT, Murphy, SM, Polke, J, Reilly, MM, Wei, Y, Winer, J   +10 more
core   +1 more source