Results 71 to 80 of about 4,211 (172)

A SELECTIVE ER-PHAGY EXERTS PROCOLLAGEN QUALITY CONTROL VIA A CALNEXIN-FAM134B COMPLEX [PDF]

, 2020
The endoplasmic reticulum (ER) is the largest cellular organelle adapting dynamically to cope with cellular stress and high demand of newly synthesized proteins.
DE LEONIBUS CHIARA
core   +1 more source

ER remodeling via ER-phagy [PDF]

, 2022
The endoplasmic reticulum (ER) is a hotspot for many essential cellular functions. The ER membrane is highly dynamic, which affects many cellular processes that take place within the ER.
Dikic, I., Gubas, A.
core   +1 more source

Inherited Sensory and Autonomic Neuropathy in a Border Collie, Interest of Oclacitinib for the Control of Self-Mutilation

Veterinary Sciences, 2022
Sensory and autonomic neuropathy was diagnosed in a five-month-old Border Collie puppy, who presented with progressive self-mutilation, proprioceptive ataxia and urinary incontinence.
Caroline Leonard, Iris Van Soens, Jacques Fontaine   +2 more
doaj   +1 more source

Targeting GRP78 and the Proteostasis Network to Break the Therapeutic Ceiling in Neuroendocrine Prostate Cancer

iNew Medicine, EarlyView.
ABSTRACT HSPA5 (also known as GRP78/BiP) is a master regulator of the endoplasmic reticulum (ER) stress response and a key node in the proteostasis network. In neuroendocrine prostate cancer (NEPC), an aggressive, therapy‐refractory lineage that emerges under pressure from androgen receptor (AR) directed therapies, GRP78 is upregulated and co‐opted to ...
Amos Olalekan Akinyemi, Md Rakibul Alam, Mithu Howlader, Mohammad Esfini Farahani, Lixiang Gu, Chun Li, Chripus Ngule, Kevin Fulp, Bolaji Owoyemi, Xinyi Wang, Samuel Nwadialo, Fatemeh Selani, Makumba Esoe, Obaleye Oluwafunminiyi, Zhiguo Li   +14 more
wiley   +1 more source

Common dysregulation network in the human prefrontal cortex underlies two neurodegenerative diseases. [PDF]

, 2014
Using expression profiles from postmortem prefrontal cortex samples of 624 dementia patients and non-demented controls, we investigated global disruptions in the co-regulation of genes in two neurodegenerative diseases, late-onset Alzheimer's disease (AD)
Casaccia, Patrizia, Emilsson, Valur, Fan, Guoping, Huynh, Jimmy L, Johnson, Andrew D, Lamb, John R, McElwee, Joshua, Melquist, Stacey, Molony, Cliona, Narayanan, Manikandan, Schadt, Eric E, Stone, David J, Suver, Christine, Wang, Kai, Xie, Tao, Yang, Xia, Yoo, Seungyeul, Zhang, Bin, Zhang, Chunsheng, Zhu, Jun   +19 more
core   +3 more sources

Sec23a inhibits the self-renewal of melanoma cancer stem cells via inactivation of ER-phagy

Cell Communication and Signaling, 2022
Background The genesis and developments of solid tumors, analogous to the renewal of healthy tissues, are driven by a subpopulation of dedicated stem cells, known as cancer stem cells (CSCs), that exhibit long-term clonal repopulation and self-renewal ...
Zhiwei Sun, Doudou Liu, Bin Zeng, Qiting Zhao, Xiaoshuang Li, Hao Chen, Jianyu Wang, H. Rosie Xing   +7 more
doaj   +1 more source

ER-phagy:shaping up and de-stressing the endoplasmic reticulum [PDF]

, 2019
The endoplasmic reticulum (ER) network has central roles in metabolism and cellular organisation. The ER undergoes dynamic alterations in morphology, molecular composition and functional specification.
An H, Anding AL, Antonucci L, Bergmann TJ, Bernales S, Birgisdottir AB, Bolender RP, Cadwell K, Caldieri G, Chen Q, Chen S, Chino H, Chiramel AI, Cinque L, Codogno P, Cubillos‐Ruiz JR, Diakopoulos KN, Dikic I, Dikic I, Dooley HC, Durr A, English AR, English L, Farre JC, Farre JC, Farre JC, Forrester A, Fregno I, Fregno I, Fry MR, Fujita E, Fumagalli F, Gammoh N, Ganley IG, Ge L, Grumati P, Grumati P, Guan J, Hailey DW, Hamasaki M, Hanna RA, Hayashi-Nishino M, Holcman D, Hotamisligil GS, Houck SA, Huh WJ, Islam F, Islam F, Jia W, Khaminets A, Khaminets A, Koh JH, Kostenko EV, Kurth I, Lamb CA, Lennemann NJ, Liang JR, Linxweiler M, Lipatova Z, Liu XM, Liu Y, Locke M, Martinez J, Mejlvang J, Mijaljica D, Mochida K, Moretti J, Nakatogawa H, Noda T, Ogata M, Oku M, Oku M, Oku M, Omari S, Pahl HL, Pang L, Papinski D, Peng Y, Pengo N, Phillips MJ, Polson HEJ, Puri C, Ravenhill BJ, Rello-Varona S, Richter B, Rogov V, Rogov VV, Ruggiano A, Sahu R, Sanjuan MA, Schroeder LK, Schuck S, Schultz ML, Shi Q, Shi W, Smith M, Smith MD, Smith MD, Todd DJ, Tooze J, Tschurtschenthaler M, Turco E, Vargas JNS, Viswanath P, Voeltz GK, Walter P, Wang M, Wild P, Yamamoto H, Yang H, Yang Y, Yla-Anttila P, Zachari M, Zhang H   +113 more
core   +1 more source

Proteostasis of organelles in aging and disease

The FEBS Journal, EarlyView.
Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, Seda Koyuncu, David Vilchez   +5 more
wiley   +1 more source

Membralin Assembles a MAN1B1–VCP Complex to Target Foreign Glycoproteins from the Endoplasmic Reticulum to Lysosomes for Degradation

Advanced Science, Volume 13, Issue 9, 13 February 2026.
This study identifies Membralin as an ER‐phagy receptor that recruits MAN1B1 and VCP to form a selective ERLAD complex. By sensing dense N‐glycan clusters on viral fusion glycoproteins, this ubiquitin‐independent pathway directs SARS‐CoV‐2 spike, Ebola GP, influenza HA, and HIV‐1 Env to lysosomal degradation, thereby limiting viral infectivity ...
Jing Zhang, Xiaoran Lu, Sunan Li, Tao Wang, Iqbal Ahmad, Yong‐Hui Zheng   +5 more
wiley   +1 more source

FAM134B promotes esophageal squamous cell carcinoma in vitro and its correlations with clinicopathologic features [PDF]

Human Pathology, 2019
Family with sequence similarity 134, member B (FAM134B) is an autophagy regulator of endoplasmic reticulum first discovered to be involved in the pathogenesis of esophageal squamous cell carcinoma (ESCC). The present study examined the functional behavior of FAM134B in cancer cells and the association of FAM134B expression with clinicopathologic ...
Islam, Farhadul, Gopalan, Vinod, Law, Simon, Tang, Johnny Cheuk-on, Lam, Alfred King-yin   +4 more
openaire   +3 more sources