Results 81 to 90 of about 4,211 (172)

Upregulation of FAM134B inhibits endoplasmic reticulum stress‐related degradation protein expression and promotes hepatocellular carcinogenesis

Journal of Cellular and Molecular Medicine, 2023
AbstractEndoplasmic reticulum (ER) stress can stimulate the proliferation and metastasis of hepatocellular carcinoma (HCC) cells while hindering apoptosis and immune system function, but the molecular mechanism of ER stress in HCC has yet to be fully studied. We aim to investigate the molecular mechanism by which FAM134B inhibits autophagy of HCC cells
Houhong Wang, Lu Liu, Huihui Gong, Heng Li   +3 more
openaire   +2 more sources

Signal-Retaining Autophagy Indicator as a Quantitative Imaging Method for ER-Phagy

Cells, 2023
Autophagy is an intracellular lysosomal degradation pathway by which cytoplasmic cargoes are removed to maintain cellular homeostasis. Monitoring autophagy flux is crucial to understand the autophagy process and its biological significance.
Natalia Jimenez-Moreno, Carla Salomo-Coll, Laura C. Murphy, Simon Wilkinson   +3 more
doaj   +1 more source

Age‐Associated Dysregulation of Postsynaptic Mitochondria Perturbs Reinnervation Kinetics

Aging Cell, Volume 25, Issue 1, January 2026.
We show that aging results in postsynaptic mitochondrial loss at the neuromuscular junction and impaired muscle reinnervation. In vivo CRISPR knockout of mitochondrial genes, CHCHD10 and CHCHD2, in young muscles led to fragmented endplates, aberrant innervation, and impaired transcriptional maturation of sub‐synaptic myonuclei during regeneration ...
Steve D. Guzman, Paula M. Fraczek, Klimentini Itsani, Esraa K. Furati, Devin Juros, Grace Kenney, Gregorio Valdez, Joe V. Chakkalakal, Carlos A. Aguilar   +8 more
wiley   +1 more source

Virus infection drives IL-2 antibody complexes into pro-inflammatory agonists in mice [PDF]

, 2016
The use of IL-2/JES6-1 Ab complex (IL-2 Ab Cx) has been considered as a potential therapeutic for inflammatory diseases due to its selective expansion of regulatory T cells (Tregs) in mice.
Amrun, Siti Naqiah, Andiappan, Anand K, Lee, Wendy WL, Lum, Fok-Moon, Ng, Lisa FP, Renia, Laurent, Rotzschke, Olaf, Teo, Teck-Hui   +7 more
core   +1 more source

Therapeutic Antibodies for Mosquito‐Borne Orthoflavivirus Infections: Discovery, Engineering Approaches, and Advances in mRNA‐Based Delivery Systems

Advanced Therapeutics, Volume 8, Issue 12, December 2025.
This review explores how antibody engineering and display technologies are driving therapeutic advances against mosquito‐borne orthoflaviviruses such as Zika, dengue, and yellow fever viruses. It highlights diverse neutralizing targets on the envelope protein, including the conserved fusion loop, and discusses how Fc engineering, rational antigen ...
Ana Clara Barbosa Antonelli, Lucas Silva Rodrigues, Maria Clara Moura Pinheiro, Sylvia Barbosa Pinhate, Marcelo de Macedo Brígido, Andréa Queiroz Maranhão   +5 more
wiley   +1 more source

Increased transport of acetylâ CoA into the endoplasmic reticulum causes a progeriaâ like phenotype [PDF]

, 2018
The membrane transporter ATâ 1/SLC33A1 translocates cytosolic acetylâ CoA into the lumen of the endoplasmic reticulum (ER), participating in quality control mechanisms within the secretory pathway. Mutations and duplication events in ATâ 1/SLC33A1 are
Campisi, Chiplunkar, Ding, Ding, Duran-Aniotz, Fumagalli, Garcia-Prat, Garcia-Prat, Gomez Ravetti, Gonzalo, Harris, Hullinger, Huppke, Jeon, Jonas, Kang, Karikkineth, Kenyon, Khaminets, Klionsky, Ko, Kroemer, Kubben, Lennemann, Lessel, Liao, Lin, Longo, Madeo, Madeo, Maier, Milman, Mochida, Nakatogawa, Ovadya, Pehar, Pehar, Peng, Peng, Peng, Pivnick, Polymeropoulos, Rubinsztein, Schuck, Swahari, Tchkonia, Tyner, Wang   +47 more
core   +1 more source

Mitochondria‐Associated Endoplasmic Reticulum Membranes as Potential Therapeutic Targets in Epilepsy

CNS Neuroscience &Therapeutics, Volume 31, Issue 12, December 2025.
MAMs are involved in the occurrence and development of epilepsy through calcium ion homeostasis imbalance, mitochondrial dysfunction, endoplasmic reticulum stress and inflammation, abnormal lipid metabolism, as well as autophagy and mitochondrial autophagy. This picture was drawn using Figdraw.
Huaiyu Sun, Xuewei Li, Weixuan Zhao, Wuqiong Zhang, Hongmei Meng   +4 more
wiley   +1 more source

ER-phagy in the Occurrence and Development of Cancer

Biomedicines, 2022
As an organelle, the endoplasmic reticulum (ER) is closely related to protein synthesis and modification. When physiological or pathological stimuli induce disorders of ER function, misfolded proteins trigger ER-phagy, which is beneficial for restoring ...
Huimin Zhou, Kexin Wang, Mengyan Wang, Wenxia Zhao, Conghui Zhang, Meilian Cai, Yuhan Qiu, Tianshu Zhang, Rongguang Shao, Wuli Zhao   +9 more
doaj   +1 more source

O‐GlcNAc Transferase Promotes Metabolic Dysfunction‐Associated Steatotic Liver Disease‐Related Hepatocellular Carcinoma by Facilitating the Degradation of PTEN

MedComm – Oncology, Volume 4, Issue 4, December 2025.
Lipid‐rich and hypoxia tumor microenvironment elevates O‐GlcNAc transferase (OGT) expression, catalyzing O‐GlcNAcylation of phosphatase and tensin homolog deleted on chromosome ten (PTEN) which in turn negatively regulates PTEN to promotes the growth of hepatocellular carcinoma (HCC).
Haoran Liu, Suming Pu, Wenxin Zhu, Jing Huang, Jianming Li   +4 more
wiley   +1 more source

Full length RTN3 regulates turnover of tubular endoplasmic reticulum via selective autophagy

eLife, 2017
The turnover of endoplasmic reticulum (ER) ensures the correct biological activity of its distinct domains. In mammalian cells, the ER is degraded via a selective autophagy pathway (ER-phagy), mediated by two specific receptors: FAM134B, responsible for ...
Paolo Grumati, Giulio Morozzi, Soraya Hölper, Muriel Mari, Marie-Lena IE Harwardt, Riqiang Yan, Stefan Müller, Fulvio Reggiori, Mike Heilemann, Ivan Dikic   +9 more
doaj   +1 more source