Results 1 to 10 of about 3,759 (127)

Non-linear pharmacokinetics of penciclovir in healthy cats after single and multiple oral administration of famciclovir [PDF]

Frontiers in Veterinary Science
IntroductionFeline Infectious Rhinobronchitis (FVR) is a common and serious infectious upper respiratory disease. Famciclovir, an antiviral prodrug initially developed for human herpesviruses, demonstrates significant therapeutic efficacy in cats with ...
Mengke Qu, Xiao Ke, Zhirong Zhang, Ling Zhang   +3 more
doaj   +2 more sources

Repurposing Purine Analog Antivirals to Modulate Serum Uric Acid: Evidence From Real-World Data. [PDF]

Clin Transl Sci
ABSTRACT Xanthine oxidase (XO) inhibitors remain the standard pharmacologic therapy for hyperuricemia. However, additional enzymatic components of the purine degradation pathway may contribute to uric acid synthesis. Guanine deaminase (GD) catalyzes the conversion of guanine to xanthine, providing substrate for downstream oxidation by XO.
Magagnoli J, Cummings TH, Wyatt MD, McInnes C, Ambati J, Sutton SS.   +5 more
europepmc   +2 more sources

Formulation of pH responsive polymeric hydrogels for prolonged delivery of famciclovir with biosafety evaluation [PDF]

Scientific Reports
Recent study aimed to fabricate pH responsive, intelligent, Pluronic F127 based polymeric system for controlled delivery of Famciclovir. Nine formulations were developed through free radical polymerization.
Irum Iftikhar, Kashif Barkat, Syed Faisal Badshah, Muhammad Umer Ashraf, Yasir Mehmood, Irfan Anjum, Gamal A. Shazly, Amira Metouekel, Youssouf Ali Younous, Mohammed Bourhia   +9 more
doaj   +2 more sources

Estimating Risks of Central Nervous System Disturbance Associated with Medications for Herpes Zoster: Findings from a Regional Population-Based Cohort Study Using the Shizuoka Kokuho Database [PDF]

Drugs - Real World Outcomes
Background Herpes zoster commonly occurs in older adults, whose renal function often declines, necessitating careful dosing of antivirals such as acyclovir, valacyclovir, and famciclovir.
Ryoya Hagiwara, Eiji Nakatani, Hideaki Kaneda, Hiroshi Okada, Hideo Hashizume, Nagato Kuriyama, Akira Sugawara   +6 more
doaj   +2 more sources

Newly identified properties of known pharmaceuticals and myxobacterial small molecules revealed by screening for autophagy modulators. [PDF]

FEBS J
Autophagy is a cellular degradation process involved in, for example, immune responses to pathogens and neurodegeneration. To identify modulators of autophagy, we developed a microscopy‐based screening assay and identified previously unknown autophagy‐modulating activities in known drugs and natural products from myxobacteria and fungi.
Fichtner J, Beer YY, Ramm HGM, Mühlen S, Surup F, Herrmann J, Meister TL, Pfaender S, Bilitewski U, Brönstrup M, Müller R, Wirth M, Eskelinen EL, Schmitz I.   +13 more
europepmc   +2 more sources

Pharmacovigilance study of famciclovir in the Food and Drug administration adverse event reporting system database [PDF]

Scientific Reports
Famciclovir, mainly used to treat herpes zoster, is rapidly transforms into penciclovir when administered orally. Our study evaluated adverse events (AEs) associated with famciclovir by mining data from the publicly available Food and Drug Administration
Runan Fang, Yang Zhou, Lu Han, Wenjing Chen, Ning Guan, Jianhong Li   +5 more
doaj   +2 more sources

Study protocol for a multicentre, randomised, double-blinded, placebo-controlled, multi-arm, multi-stage, trial of SpironolacTone and famciclOovir in the treatment of Progressive Multiple Sclerosis to prevent disability progression: the STOP-MS trial [PDF]

BMJ Neurology Open
Introduction Targeting progressive multiple sclerosis (MS) addresses the current single biggest unmet need in the MS therapeutic landscape and anti-Epstein-Barr virus (EBV) therapy potentially strikes at the root cause. The SpironolacTone and famciclOvir
, Nevin John, Jeremy Chataway, Gavin Giovannoni, Tomas Kalincik, Jeannette Lechner-Scott, Suzanne Hodgkinson, Vilija Jokubaitis, Helmut Butzkueven, Yuan Zhou, Anne-Louise Ponsonby, Vivien Li, Allan G Kermode, Jing Sun, Stefan Blum, Michael Levy, Amit Bar-Or, Mastura Monif, Corey Smith, Rajiv Khanna, Mahesh Parmar, Lawrence Steinman, Andrew Potter, Silvana Gaudieri, Izanne Roos, Joshua Barton, Heidi Beadnall, Todd Hardy, Katherine Buzzard, Lauren Giles, Vicki Maltby, Sudarshini Ramanathan, John D Parratt, Richard A L Macdonell, Sanjay Swaminathan, Sean Riminton, Zara Ioannides, Janakan Ravindran, Trevor J Kilpatrick, Kayla Ward, Anne Bruestle, Anneke van der Walt, Fiona McKay, Marzena Pedrini, Lesley-Ann Hall, Kaylene Young, Vanessa Vigar, Sabrina Oishi, Lidia Madrid San Martin, Belinda Kaskow, Grant Parnell, Julie A. Campbell, David Tscharke, Erin Brady, William M. Carroll, Michael H. Barnett, Bruce V. Taylor, Simon A. Broadley, Scott Byrne, Stephanie Trend, Tim Wang, Pam A McCombe, Tri Phan, Steven Petratos, Chhavi Asthana, Julia Morahan, Nigel Caswell   +66 more
doaj   +2 more sources

Association between the use of anti-herpetic drugs and subsequent initiation of Alzheimer’s disease drug treatment: Dutch population-based inception cohort study [PDF]

BMJ Open
Objectives To examine whether exposure to anti-herpetic drugs (AHDs: acyclovir, valacyclovir, famciclovir) is associated with reduced risk of Alzheimer’s disease (AD) treatment initiation.Design Population-based retrospective matched cohort study.Setting
Barbara C van Munster, Eelko Hak, Jens H J Bos, Ali Alghamdi, Spyros Balafas, Karim Rafie, Amalia M Dolga   +6 more
doaj   +2 more sources

Doxycycline with or without famciclovir for infectious ophthalmic and respiratory disease: a prospective, randomized, masked, placebo-controlled trial in 373 kittens [PDF]

Journal of Feline Medicine and Surgery
Objectives The aim of this study was to prospectively evaluate in a randomized, triple-masked, placebo-controlled trial, outcomes for kittens with ocular manifestations of infectious upper respiratory disease (IURD) treated with an ophthalmic and oral ...
Karen M Vernau, Soohyun Kim, Sara M Thomasy, Danica R Lucyshyn, Jordyn Purpura, Elizabeth Montgomery, Jennifer D Surmick, Ariana R Dubelko, Ardalan Moussavi, Philip H Kass, David J Maggs   +10 more
doaj   +2 more sources

Refractory acute retinal necrosis presenting as peripapillary choroiditis – A diagnostic and therapeutic challenge [PDF]

Indian Journal of Ophthalmology
This report describes a challenging case of refractory acute retinal necrosis (ARN) with peripapillary choroiditis as the initial presenting sign.
Ankush Kawali, Sai Bhakti Mishra, Padmamalini Mahendradas, Rohit Shetty   +3 more
doaj   +2 more sources