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Familial Risks and Proportions Describing Population Landscape of Familial Cancer. [PDF]

Cancers (Basel), 2021
Background: Familial cancer can be defined through the occurrence of the same cancer in two or more family members. We describe a nationwide landscape of familial cancer, including its frequency and the risk that it conveys, by using the largest family ...
Hemminki K, Sundquist K, Sundquist J, Försti A, Hemminki A, Li X.   +5 more
europepmc   +4 more sources

Editorial: Familial Cancer in China: From Detection to Screening and Management [PDF]

Frontiers in Oncology, 2022
Tianhui Chen, Ying Yuan
doaj   +2 more sources

A Comparison of Patient-Reported Outcomes Following Consent for Genetic Testing Using an Oncologist- or Genetic Counselor-Mediated Model of Care

Current Oncology, 2021
This study compares knowledge, experience and understanding of genetic testing, and psychological outcomes among breast and ovarian cancer patients undergoing multi-gene panel testing via genetic counselor-mediated (GMT) or oncologist-mediated (OMT ...
Jeanna M. McCuaig, Emily Thain, Janet Malcolmson, Sareh Keshavarzi, Susan Randall Armel, Raymond H. Kim   +5 more
doaj   +1 more source

Morphological Analyses of Colorectal Adenocarcinomas in Japanese Familial Adenomatous Polyposis Patients

Journal of the Anus, Rectum and Colon, 2022
Objectives: This retrospective study was conducted to clarify the morphological characteristics of colorectal cancer (CRC) in Japanese familial adenomatous polyposis (FAP) patients.
Yozo Suzuki, Fumio Ishida, Hideyuki Ishida, Hideki Ueno, Hirotoshi Kobayashi, Tatsuro Yamaguchi, Tsuyoshi Konishi, Yukihide Kanemitsu, Takao Hinoi, Yasuhiro Inoue, Naohiro Tomita, Kenichi Sugihara   +11 more
doaj   +1 more source

Personalising genetic counselling (POETIC) trial: Protocol for a hybrid type II effectiveness-implementation randomised clinical trial of a patient screening tool to improve patient empowerment after cancer genetic counselling

Trials, 2023
Background Genetic counselling aims to identify, and address, patient needs while facilitating informed decision-making about genetic testing and promoting empowerment and adaptation to genetic information.
Laura E. Forrest, Erin Tutty, Anurika P. De Silva, Lara Petelin, Amy Ruscigno, Rebecca Purvis, Katrina Monohan, Maira Kentwell, Adrienne Sexton, Lesley Stafford, Paul A. James   +10 more
doaj   +1 more source

Comparison of Clinicopathological Characteristics Between Primary and Contralateral Cancers in BRCA1/2 Carriers with Metachronous Bilateral Breast Cancers

Zhongliu Fangzhi Yanjiu, 2023
Objective To compare the clinicopathological characteristics between primary and contralateral cancers in patients with metachronous bilateral breast cancer (MBBC) who carried a BRCA1/2 germline pathogenic variant. Methods A total of 496 BRCA1/2 carriers
DING Xinyun, SUN Jie, CHEN Jiuan, YAO Lu, XU Ye, XIE Yuntao, ZHANG Juan   +6 more
doaj   +1 more source

Cancer risk in relatives of BRCA1/2 pathogenic variant carriers in a large series of unselected patients with breast cancer

Cancer Biology & Medicine, 2023
Objective: The spectrum and risk of cancer in relatives of BRCA1/2 pathogenic variant carriers in the Chinese population have not been established. Methods: A family history of cancer in 9903 unselected breast cancer patients was retrospectively analyzed.
Jiaming Liu, Lu Yao, Jie Sun, Li Hu, Jiuan Chen, Juan Zhang, Ye Xu, Yuntao Xie   +7 more
doaj   +1 more source

Apparent regional differences in the spectrum of BARD1 pathogenic variants in Spanish population and importance of copy number variants

Scientific Reports, 2022
Only up to 25% of the cases in which there is a familial aggregation of breast and/or ovarian cancer are explained by germline mutations in the well-known BRCA1 and BRCA2 high-risk genes.
B. Benito-Sánchez, A. Barroso, V. Fernández, F. Mercadillo, R. Núñez-Torres, G. Pita, L. Pombo, R. Morales-Chamorro, J. M. Cano-Cano, M. Urioste, A. González-Neira, A. Osorio   +11 more
doaj   +1 more source

Clinical relevance of pathogenic germline variants in mismatch repair genes in Chinese breast cancer patients

npj Breast Cancer, 2022
The prevalence and clinical relevance of pathogenic germline variants in MMR genes have not been investigated in large series of breast cancers. In this study, we screened the germline variants in MMR genes in 8085 consecutive Chinese breast cancer ...
Li Hu, Jie Sun, Zhongwu Li, Ziwei Qu, Yan Liu, Qiting Wan, Jiaming Liu, Xinyun Ding, Fan Zang, Juan Zhang, Lu Yao, Ye Xu, Yin Wang, Yuntao Xie   +13 more
doaj   +1 more source

Psychological and health behaviour outcomes following multi-gene panel testing for hereditary breast and ovarian cancer risk: a mini-review of the literature

Hereditary Cancer in Clinical Practice, 2022
Introduction Knowledge of the genetic mechanisms driving hereditary breast and ovarian cancer (HBOC) has recently expanded due to advances in gene sequencing technologies.
Lindsay Carlsson, Emily Thain, Brittany Gillies, Kelly Metcalfe   +3 more
doaj   +1 more source