Results 71 to 80 of about 3,068 (175)

Multi‐Region Brain Organoids Integrating Cerebral, Mid‐Hindbrain, and Endothelial Systems

Advanced Science, Volume 12, Issue 33, September 4, 2025.
Multi‐Region Brain Organoids combine cerebral, mid/hindbrain, and endothelial components into an advanced 3D model capturing 80% of fetal brain cellular diversity. This platform reveals essential endothelial‐neural signaling networks that maintain region‐specific intermediate progenitors during hindbrain development.
Anannya Kshirsagar, Hayk Mnatsakanyan, Sai Kulkarni, John Guo, Kai Cheng, Luke Daniel Ofria, Oce Bohra, Ram Sagar, Vasiliki Mahairaki, Christian E Badr, Annie Kathuria   +10 more
wiley   +1 more source

From multi‐omics to precision medicine in intracranial aneurysm: Biomarker discovery and multimodal integration

Interdisciplinary Medicine, Volume 3, Issue 5, September 2025.
This review explores intracranial aneurysm biomarker discovery through multi‐omics. It reveals key genes, proteins, and metabolites, and shows how machine‐learning‐based multi‐modal integration may aid diagnosis and treatment. Abstract Despite extensive research, currently, no biomarkers are available for clinical use in intracranial aneurysm (IA ...
Jiaxin Zhang, Yufei Yang, Bingxu Chen, Yanmeng Zhao, Haitao Sun   +4 more
wiley   +1 more source

Automated algorithm for counting microbleeds in patients with familial cerebral cavernous malformations [PDF]

Neuroradiology, 2017
Familial cerebral cavernous malformation (CCM) patients present with multiple lesions that can grow both in number and size over time and are reliably detected on susceptibility-weighted imaging (SWI). Manual counting of lesions is arduous and subject to high variability. We aimed to develop an automated algorithm for counting CCM microbleeds (lesions
Zou, Xiaowei, Hart, Blaine L, Mabray, Marc, Bartlett, Mary R, Bian, Wei, Nelson, Jeffrey, Morrison, Leslie A, McCulloch, Charles E, Hess, Christopher P, Lupo, Janine M, Kim, Helen   +10 more
openaire   +4 more sources

Bleeding of a familial cerebral cavernous malformation after prophylactic anticoagulation therapy [PDF]

Neurosurgical Focus, 2006
✓The risk of hemorrhage in cavernous malformations (CMs) depends on lesion, host, and environmental factors. Anticoagulation therapy is a well-known risk factor for intracerebral bleeding, but the occurrence of hemorrhages in patients with CMs has not been reported.
Eugenio, Pozzati, Mino, Zucchelli, Anna Federica, Marliani, Luca Albini, Riccioli   +3 more
openaire   +2 more sources

Metabolic Factors Related to Interpersonal Dysfunction in Acromegaly: A Nationwide Cross‐Sectional Study in China

CNS Neuroscience &Therapeutics, Volume 31, Issue 9, September 2025.
Metabolic and physical factors—specifically frontal bossing, cardiovascular comorbidities, and elevated preoperative GH levels—are independent predictors of severe interpersonal dysfunction in Chinese patients with acromegaly. These findings underscore the need for integrating systematic psychosocial screening into routine neuroendocrine management to ...
Shashi Kiran Tagilapalli, Zongming Wang, Yuechu Lucinda Lu, Guofeng Zhang, Weijie Su, Zhentian Wu, Jiaming Wang, Qing Rao, Haijun Wang, Dongsheng He, Yonggao Mou, Shun Yao, Yanmei Tie, Wenli Chen   +13 more
wiley   +1 more source

Blue rubber-bleb nevus syndrome: report of a familial case with a dural arteriovenous fistula [PDF]

, 2003
We report a case of a 45-year-old woman known to have a familial form of blue rubber-bleb nevus syndrome (BRBNS). The patient developed severe occipital headaches and bilateral retroauricular bruits.
Barbosa, V, Carvalho, S, Machado, E, Santos, N   +3 more
core  

Clinical Characteristics Analysis of Vestibular Migraine Combined With Unruptured Intracranial Aneurysm

Brain and Behavior, Volume 15, Issue 8, August 2025.
We observed significant differences in the distribution of unruptured intracranial aneurysm (UIA) between the vestibular migraine (VM) and migraine groups compared to the control group. Furthermore, intergroup comparisons of morphological parameters indicated that both VM (non‐spherical index) and migraine (age) patients have a higher risk of aneurysm ...
Yaoheng Zhang, Yi Ju, Chunling Liu, Hui Li, Yanlu Jia, Shuning Sun, Haozhe Yin, Suisui Ma, Wenbo Peng   +8 more
wiley   +1 more source

Large language models assisted multi-effect variants mining on cerebral cavernous malformation familial whole genome sequencing

Computational and Structural Biotechnology Journal
Cerebral cavernous malformation (CCM) is a polygenic disease with intricate genetic interactions contributing to quantitative pathogenesis across multiple factors.
Yiqi Wang, Jinmei Zuo, Chao Duan, Hao Peng, Jia Huang, Liang Zhao, Li Zhang, Zhiqiang Dong   +7 more
doaj   +1 more source

Familial Cerebral Cavernous Malformations : A Clinical Series and Literature Review. [PDF]

J Korean Neurosurg Soc
Objective : Familial cerebral cavernous malformation (FCCM) is a genetically inherited condition involving the collection of abnormal slow-flow venous capillaries with no cerebral parenchyma in between. In this case series, we review the clinical, radiological, pathological, and genetic findings of seven blood relatives diagnosed with FCCM and discuss ...
Dogu H, Mucuoglu AO, Gokoglu A, Gasimli R, Tepeli E, Akdemir H.   +5 more
europepmc   +2 more sources

Ethical considerations of disclosure of iatrogenic cerebral amyloid angiopathy

Alzheimer's &Dementia, Volume 21, Issue 7, July 2025.
Abstract Cerebral amyloid angiopathy (CAA) causes stroke and cognitive decline. The recently identified iatrogenic CAA subtype (iCAA) is thought to be transmitted through medical procedures involving cadaveric human material and potentially neurosurgical instruments or blood transfusions. This raises ethical questions concerning disclosure of iCAA.
Kanishk Kaushik, Marleen M. Eijkholt, Nienke de Graeff, Gargi Banerjee, David J. Werring, Gisela M. Terwindt, Ellis S. van Etten, Marieke J. H. Wermer   +7 more
wiley   +1 more source