Results 81 to 90 of about 827,976 (177)

Framework for headache management in pediatric patients with stroke and cerebrovascular lesions: A narrative review

Headache: The Journal of Head and Face Pain, Volume 66, Issue 9, Page 2138-2155, October 2026.
Abstract Objective To present a practical, evidence‐based framework for the management of headache disorders in pediatric patients with prior stroke or underlying cerebral vascular lesions, with particular attention to safety and efficacy of pharmacologic and non‐pharmacologic therapies.
Allison C. Hyland, Samuel J. Belfer, Christine K. Fox, Samantha L. Irwin, Rachel Vassar, Ann Oh, Sruthi Ilangovan, Amy A. Gelfand   +7 more
wiley   +1 more source

Magnetic Resonance Imaging of KRIT1 Associated Familial Cerebral Cavernous Malformations at 7‐Tesla

Neurology and Clinical Neuroscience, EarlyView.
Sam J. Neilson, Natasha E. Fullerton, David Porter, Keith W. Muir   +3 more
wiley   +1 more source

Capillary Malformation/Arteriovenous Malformation

, 2013
Vascular anomalies are a heterogeneous group of disor- ders divided into tumors and malformations based on clinical, radiologic, and immunohistochemical studies.
Boon, Laurence M., Revencu, Nicole, Vikkula, Miikka, Laurence M. Boon, Nicole Revencu, Miikka Vikkula   +5 more
core   +1 more source

Automated algorithm for counting microbleeds in patients with familial cerebral cavernous malformations [PDF]

Neuroradiology, 2017
Familial cerebral cavernous malformation (CCM) patients present with multiple lesions that can grow both in number and size over time and are reliably detected on susceptibility-weighted imaging (SWI). Manual counting of lesions is arduous and subject to high variability. We aimed to develop an automated algorithm for counting CCM microbleeds (lesions
Zou, Xiaowei, Hart, Blaine L, Mabray, Marc, Bartlett, Mary R, Bian, Wei, Nelson, Jeffrey, Morrison, Leslie A, McCulloch, Charles E, Hess, Christopher P, Lupo, Janine M, Kim, Helen   +10 more
openaire   +4 more sources

Symptomatic midbrain cerebral cavernous malformation after extreme altitude exposure: a case report and PRISMA-guided structured literature review

Interdisciplinary Neurosurgery
Background: It is unknown whether hypoxic exposure or extreme altitude can precipitate cerebral cavernous malformation (CCM) instability or hemorrhage.Case Presentation: A 25-year-old man with familial CCM1/KRIT1 disease developed acute vertigo and ...
Bader Ali, Ahmad Sweid, Justine Lee, Georgio Sader, Agnieszka Stadnik, Miguel A. Lopez-Ramirez, Robert Shenkar, Issam A. Awad   +7 more
doaj   +1 more source

Defective autophagy is a key feature of cerebral cavernous malformations

EMBO Molecular Medicine, 2015
Cerebral cavernous malformation (CCM) is a major cerebrovascular disease affecting approximately 0.3–0.5% of the population and is characterized by enlarged and leaky capillaries that predispose to seizures, focal neurological deficits, and fatal ...
Saverio Marchi, Mariangela Corricelli, Eliana Trapani, Luca Bravi, Alessandra Pittaro, Simona Delle Monache, Letizia Ferroni, Simone Patergnani, Sonia Missiroli, Luca Goitre, Lorenza Trabalzini, Alessandro Rimessi, Carlotta Giorgi, Barbara Zavan, Paola Cassoni, Elisabetta Dejana, Saverio Francesco Retta, Paolo Pinton   +17 more
doaj   +1 more source

Impact of Modifiable Cardiovascular Risk Factors and Protective Therapies on Hemorrhagic Events in Cerebral Cavernous Malformations: A Systematic Review and Meta‐Analysis [PDF]

Brain Behav
ABSTRACT Background Cerebral cavernous malformations (CCM) are vascular lesions prone to hemorrhage, but the influence of modifiable cardiovascular risk factors and commonly prescribed therapies on bleeding risk remains unclear. Methods We performed a systematic review and meta‐analysis according to PRISMA 2020.
Sanikommu S, Santos A, Dawoud B, Sherman J, Wipplinger C, Jaman E, Toledo J, Abdelsalam A, Lu V, Wang A, Starke R.   +10 more
europepmc   +2 more sources

Costello Syndrome Associated With Somatic Mosaicism of Rare p.Gly13Asp HRAS Variant: Expanding the Phenotypic Spectrum

Molecular Genetics &Genomic Medicine, Volume 14, Issue 9, September 2026.
We report a case of a 22‐year‐old woman with predominantly cutaneous involvement in whom whole‐exome sequencing from both blood‐ and hair‐derived DNA samples identified somatic mosaicism for the rare HRAS p.Gly13Asp variant. This case expands the phenotypic spectrum of Costello syndrome and underscores the importance of multitissue genomic analysis ...
Jovan Lalosevic, Katarina Djordjevic, Mirjana Gajic‐Veljic, Sonja Pavlovic, Vladimir Gasic, Marina Andjelkovic, Milos Nikolic   +6 more
wiley   +1 more source

Real‐world‐data for phenotypes and genotypes of rare monogenic genetic epilepsies and genes of uncertain significance for epilepsy

Epilepsia Open, Volume 11, Issue 4, Page 1184-1199, August 2026.
Abstract Objectives The objectives of this study were to develop a real‐world‐data (RWD) database for patients with epilepsy to provide further real‐world‐evidence (RWE) for monogenic genetic epilepsies; to assess the usefulness of a diagnostic algorithm in epilepsy; and to examine protein 3D structures using in silico tools to predict variant ...
Haley Morris, Elizabeth Mathew, Shalini Bahl, Marta Villa‐Lopez, Saadet Mercimek‐Andrews   +4 more
wiley   +1 more source

Familial Cerebral Cavernous Malformations : A Clinical Series and Literature Review

Journal of Korean Neurosurgical Society
Objective : Familial cerebral cavernous malformation (FCCM) is a genetically inherited condition involving the collection of abnormal slow-flow venous capillaries with no cerebral parenchyma in between. In this case series, we review the clinical, radiological, pathological, and genetic findings of seven blood relatives diagnosed with FCCM and discuss ...
Huseyin Dogu, Ali Osman Mucuoglu, Abdulkerim Gokoglu, Roya Gasimli, Emre Tepeli, Hidayet Akdemir   +5 more
openaire   +4 more sources