Results 21 to 30 of about 234,110 (135)

Advances in Migraine Mechanisms and Treatment

Pediatric Neurology Briefs, 2004
Migraine mechanisms are discussed in relation to familial hemiplegic migraine (FHM) genotypes by investigators from the Massachusetts General Hospital, Boston, and Universities in Ankara, Turkey.
J Gordon Millichap
doaj   +1 more source

The ATP1A2 Mutation Associated with Hemiplegic Migraines: Case Report and Literature Review

Clinical and Translational Neuroscience, 2022
Familial hemiplegic migraine type 2 is a premonitory subtype of migraine caused by an ATP1A2 gene mutation. It is an autosomal dominant genetic disease.
Changyue Liu, Wei Yue
doaj   +1 more source

Neurovascular changes in magnetic resonance imagining and single-photon emission computed tomography during migraine attack in patients with FHM2 mutations

Cephalalgia Reports, 2020
The aim of this article is to provide neuroimaging data on cases with familial hemiplegic migraine (FHM). A 14-year-old male presented normal diffusion-weighted magnetic resonance imaging (DWI) and fluid-attenuated inversion recovery (FLAIR) findings ...
Azusa Nagai, Daiki Tanaka, Kiyomi Kuroshima, Shigehisa Ura, Kazuto Yoshida, Yuji Takahashi, Ichiro Yabe   +6 more
doaj   +1 more source

Characterizing a Novel Metabolic Pathogenic Mechanism in Familial Hemiplegic Migraine [PDF]

, 2021
Migraine, an episodic neurological disorder, afflicts about 1 in 10 people at least monthly, yet the underlying pathophysiological mechanisms remain poorly understood.
Smith, Sarah Elizabeth
core   +1 more source

Manifestations of Familial Hemiplegic Migraine

Pediatric Neurology Briefs, 2012
Researchers at University of Arkansas, Little Rock, AR report 3 cases of familial hemiplegic migraine complicated by reversible cerebral edema and followed by neurocognitive impairment.
J Gordon Millichap
doaj   +1 more source

Inefficient constitutive inhibition of P2X3 receptors by brain natriuretic peptide system contributes to sensitization of trigeminal sensory neurons in a genetic mouse model of familial hemiplegic migraine

Molecular Pain, 2016
Background On trigeminal ganglion neurons, pain-sensing P2X3 receptors are constitutively inhibited by brain natriuretic peptide via its natriuretic peptide receptor-A. This inhibition is associated with increased P2X3 serine phosphorylation and receptor
Anna Marchenkova PhD, Sandra Vilotti PhD, Niels Ntamati MS, Arn MJM van den Maagdenberg PhD, Andrea Nistri MD   +4 more
doaj   +1 more source

Familial Episodic Amaurosis

Pediatric Neurology Briefs, 2004
A family with a stereotyped unilateral or bilateral transient visual loss, that recurred many times daily and was associated with childhood epilepsy and familial hemiplegic migraine, is reported from University Hospitals, Geneva, Switzerland.
J Gordon Millichap
doaj   +1 more source

First FHM3 mouse model shows spontaneous cortical spreading depolarizations

Annals of Clinical and Translational Neurology, 2020
Here we show, for the first time, spontaneous cortical spreading depolarization (CSD) events – the electrophysiological correlate of the migraine aura – in animals by using the first generated familial hemiplegic migraine type 3 (FHM3) transgenic mouse ...
Nico A. Jansen, Anisa Dehghani, Margot M. L. Linssen, Cor Breukel, Else A. Tolner, Arn M. J. M. van denMaagdenberg   +5 more
doaj   +1 more source

New CACNA1A deletions are associated to migraine phenotypes

The Journal of Headache and Pain, 2018
Background Familial hemiplegic migraine type 1 (FHM1) is a form of migraine with aura caused by heterozygous mutations in 4 genes: CACNA1A, ATP1A2, SNC1A and PRRT2, but further heterogeneity is expected.
G. S. Grieco, S. Gagliardi, I. Ricca, O. Pansarasa, M. Neri, F. Gualandi, G. Nappi, A. Ferlini, C. Cereda   +8 more
doaj   +1 more source

Epilepsy in patients with familial hemiplegic migraine

, 2021
Objective: : The coexistence of epilepsy in familial hemiplegic migraine (FHM) has not been reviewed systematically. We investigated the associations of epilepsy in patients with FHM with CACNA1A, ATP1A2, SCN1A or PRRT2 mutations along with clinical and ...
Eser, Metin, Kemal Tutkavul, Tutkavul, Kemal, Hasırcı Bayır, Buse Rahime, Metin Eser, Betül Baykan, Buse Rahime Hasırcı Bayır, Baykan, Betül   +7 more
core   +1 more source