Results 71 to 80 of about 234,110 (135)

Interictal cortical excitability to magnetic stimulation in familial hemiplegic migraine

, 1997
We studied interictal cortical excitability with magnetic stimulation in controls, in patients with migraine with aura, and in patients with familial hemiplegic migraine (FHM), in which ictal hemiparesis occurs.
Ferrari, Michel D., Maassen van den Brink, Antoinette, van der Kamp, Wim, van Dijk, J. Gert   +3 more
core   +1 more source

Generation of iPSC line (FMCPGHi003-A) from human PBMCs of a patient with Familial hemiplegic migraine type 3

Stem Cell Research
Peripheral blood mononuclear cells (PBMCs) were obtained from a patient diagnosed with Familial Hemiplegic Migraine Type 3, who carried a heterozygous A > C mutation in the SCN1A gene and reprogrammed using CytoTuneTM-iPS 2.0 Sendai Reprogramming Kit ...
Tao Wang, Yanan Li, Chunxiao Yang, Huijuan Yuan, Weinan Na, Shengyuan Yu   +5 more
doaj   +1 more source

Mutated Ca2.1 Channels Dysregulate CASK/P2X3 Signaling in Mouse Trigeminal Sensory Neurons of R192Q Cacna1a Knock-in Mice

Molecular Pain, 2013
Background ATP-gated P2X3 receptors of sensory ganglion neurons are important transducers of pain as they adapt their expression and function in response to acute and chronic nociceptive signals.
Aswini Gnanasekaran, Tanja Bele, Swathi Hullugundi, Manuela Simonetti, Michael D Ferrari, Arn MJM van den Maagdenberg, Andrea Nistri, Elsa Fabbretti   +7 more
doaj   +1 more source

Enhanced Subcortical Spreading Depression in Familial Hemiplegic Migraine Type 1 Mutant Mice

, 2011
Familial hemiplegic migraine type 1, a monogenic migraine variant with aura, is linked to gain-of-function mutations in theCACNA1Agene encoding CaV2.1 channels.
Kim, Y.R., Yuzawa, Izumi, Qin, Tao, Christian Waeber, Wang, Yumei, Baek, Kwangyeol, Young Ro Kim, Wang, Y.M., Dilekoz, ERGİN, Cenk Ayata, Moskowitz, M.A., Waeber, Christian, Yumei Wang, Ferrari, Michel D., Ulrike Hoffmann, Maagdenberg, A.M.J.M. van den, Ayata, Cenk, Hoffmann, Ulrike, Ayata, C., Arn M. J. M. van den Maagdenberg, Katharina Eikermann-Haerter, Waeber, C., Ergin Dilekoz, Eikermann-Haerter, Katharina, Tao Qin, Kim, Young Ro, Michael A. Moskowitz, Eikermann-Haerter, K., Baek, K., Moskowitz, Michael A., Izumi Yuzawa, Qin, T., Ferrari, M.D., Michel D. Ferrari, Yuzawa, I., Dilekoz, E., Hoffmann, U., van den Maagdenberg, Arn M. J. M., Kwangyeol Baek   +38 more
core   +1 more source

Is there any Genetic Correlation between CACNA1A Gene and Common Migraine in Iran?

مجله دانشکده پزشکی اصفهان, 2013
Background: Familial hemiplegic migraine (FHM), a rare type of migraine with aura, is genetically heterogeneous. Involvement of CACNA1A gene is demonstrated in FHM. In the present study, we searched for 6 common mutations in CACNA1A gene in patients with
Maryam Ostadsharif, Abbas Ghorbani, Mansoor Salehi, Rokhsareh Meamar   +3 more
doaj  

Genes Associated with Coma or Recurrent Coma and Role of Next Generation Sequencing in Diagnosis of Disease-Causing Genes

Medical Laboratory Journal, 2022
Coma is a state of prolonged unconsciousness. Some coma cases result from inherited disorders such as fatty-acid β-oxidation disorder, acute intermittent porphyria (due to mutations in genes CPT I, CPTII and ACADM), urea cycle defects (due to mutation in
fatemeh asadi, hamedreza goodarzi, javad zahiri, mojtaba jafarinia   +3 more
doaj  

Serial MRI in a case of familial hemiplegic migraine

We report MRI findings in a patient with familial hemiplegic migraine (FHM) with repeated episodes of hemiparesis. FHM is caused by a penetrant autosomal dominant genetic mutation; several mutations have been genotyped, involving brain-expressed ion ...
Ramesh V, Butteriss DJA, Birchall D
core   +5 more sources

Mutation analysis of CACNA1A gene in Iranian migrainous and review literatures

Journal of Research in Medical Sciences, 2013
Background: There are contrary results about the role of CACNA1A gene in the causation of common migraine in different populations. However, migraine may be genetically heterogeneous and more studies in different families and populations are required for
Rokhsareh Meamar, Maryam Ostadsharif, Mohammad Saadatnia, Abbas Ghorbani, Nayereh Nouri, Leila Dehghani, Mansoor Salehi   +6 more
doaj  

Chronic pregabalin treatment protects against spreading depolarization and alters hippocampal synaptic characteristics in a model of familial hemiplegic migraine-type 1. [PDF]

Mol Brain, 2023
Cain SM, Alles SRA, Gopaul R, Bernier LP, Yung AC, Bauman A, Yang Y, Baker GB, Kozlowski P, MacVicar BA, Snutch TP.   +10 more
europepmc   +1 more source

Optogenetic cortical spreading depolarization induces headache-related behaviour and neuroinflammatory responses some prolonged in familial hemiplegic migraine type 1 mice. [PDF]

J Headache Pain, 2023
Dehghani A, Schenke M, van Heiningen SH, Karatas H, Tolner EA, van den Maagdenberg AMJM.   +5 more
europepmc   +1 more source