Results 241 to 250 of about 52,688 (314)

The Effect of Age on Improvement in Health‐Related Quality of Life After Percutaneous Coronary Intervention

Clinical Cardiology, Volume 49, Issue 1, January 2026.
The effect of age on improvement in health‐related quality of life (HRQoL) after percutaneous coronary intervention (PCI)—Do older adults benefit from PCI equally to their younger peers in respect of HRQoL and symptom relief? ABSTRACT Introduction Percutaneous coronary intervention (PCI) is the first‐line therapy in patients scheduled for coronary ...
Laura Lappalainen, Piia Lavikainen, Risto P. Roine, Harri Sintonen, Janne Martikainen, Anna‐Maija Tolppanen, Juha Hartikainen   +6 more
wiley   +1 more source

Opportunistic Genomic Screening for Familial Hypercholesterolemia to Improve Low-Density Lipoprotein Cholesterol: A Randomized Clinical Trial.

JAMA Netw Open
Vassy JL, Brunette CA, Yi T, Assimes TL, Christensen KD, Knowles JW, Sturm AC, Sun YV, Alexander N, Cardellino MP, Harrison A, Gerety HL, Pyatt M, Vered R, Wilson PWF, Natarajan P, Whitbourne SB, Gaziano JM, Muralidhar S, Danowski ME, Veterans Affairs Million Veteran Program.   +20 more
europepmc   +1 more source

Diagnostic and Therapeutic Challenges of Homozygous and Severe Heterozygous Familial Hypercholesterolemia from Clinical Aspect-A Single-Center Study. [PDF]

J Clin Med
Nádró B, Kaluha J, Lőrincz H, Varga É, Balogh I, Harangi M.   +5 more
europepmc   +1 more source

Optimization of 4‐Amino‐2‐Pyridone Inhibitors of Proprotein Convertase Subtilisin/Kexin Type 9: Integrating Structure–Activity and Structure–Metabolism Relationships

ChemMedChem, Volume 21, Issue 1, January 2026.
Green chemistry‐based late‐stage functionalization (LSF) of the anti‐proprotein convertase subtilisin/kexin type 9 (PCSK9) early lead compound 5c led to optimized analogs with improved metabolic stability/PCSK9 IC50 ratio. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a key drug target for the treatment of different hypercholesterolemia ...
Lisa Giannessi, Maria Giovanna Lupo, Martina Ugolotti, Bianca Papotti, Beatrice Mattina, Maria Grazia Martina, Anna Demurtas, Cristina Padula, Sara Nicoli, Marco Crescenzio, Nicola Ferri, Francesca Zimetti, Marco Radi   +12 more
wiley   +1 more source

Polymorphisms in the proprotein convertase subtilisin/kexin type 9 gene in clinically diagnosed patients with familial hypercholesterolemia. [PDF]

Rev Assoc Med Bras (1992)
Costa ALDS, Santos JED, Salgado Junior W, Bertoncini-Silva C, Bizari L, Moura GSPL, Liberatore Junior RDR, Zorzo RA, Suen VMM.   +8 more
europepmc   +1 more source

DSOK‐0011 Potentially Regulates Circadian Misalignment and Affects Gut Microbiota Composition in Activity‐Based Anorexia Model

International Journal of Eating Disorders, Volume 59, Issue 1, Page 54-69, January 2026.
ABSTRACT Objective Anorexia nervosa (AN) is a metabolic‐psychiatric disorder characterized by severe weight loss, hypercortisolemia, and hypothalamic–pituitary–adrenal (HPA) axis activation. In this study, we investigated the effect of inhibiting cortisol regeneration via the enzyme 11β‐hydroxysteroid dehydrogenase type 1 (11β‐HSD1) on the ...
Hiroki Kawai, Nanami Wada, Shinji Sakamoto, Kenji Miyazaki, Taro Kato, Yoshihiro Horiuchi, Hiroshi Kirii, Hoang Duy Nguyen, Kenji Hinotsu, Yoshio Ohya, Takahiro Asada, Akiyoshi Yokode, Yuko Okahisa, Haruko Miyazaki, Toshitaka Oohashi, Manabu Takaki   +15 more
wiley   +1 more source

Current Status and Clinical Characteristics of Familial Hypercholesterolemia Patients in Korea: A Multicenter, Real-World Experience. [PDF]

Diagnostics (Basel)
Kim KA, Jung MK, Kim ES, Kim D, Kim J, Kim HS, Youn JC.   +6 more
europepmc   +1 more source

493 Knowledge of Familial Hypercholesterolemia Among Cardiology Healthcare Providers [PDF]

Isha Kalia, Lusha W. Liang, Ronald Shope, Muredach P. Reilly, Lisa Schwartz   +4 more
openalex   +1 more source

Association Between Dietary Fatty Acid Intake With Cardiovascular Disease Risk and Serum Lipid Levels

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 1, January 2026.
The findings suggest a protective role of MUFA intake against CVDs risk. ABSTRACT Background Despite early interest in the effects of dietary fats on cardiovascular diseases (CVDs), substantial controversy remains regarding the evidence linking different types of fatty acids to CVDs.
Naeemeh Hassanpour Ardekanizadeh, Khadijeh Abbasi Mobarakeh, Sheyda Nami, Maryam Shojaei, Seyed Fazel Nasimi, Saba Moradi, Faezeh Tejareh, Yeganeh Shekari, Parsa Bahmani, Maryam Gholamalizadeh, Marjan Ajami, Akram Kooshki, Saeid Doaei   +12 more
wiley   +1 more source

Liver Transplantation in a Child With Homozygous Familial Hypercholesterolemia: A Case Report and Literature Review. [PDF]

Rev Cardiovasc Med
Zhong C, Li Z, Liu Y, Xu B, Kang L.
europepmc   +1 more source