Results 221 to 230 of about 224,441 (293)

A New Paradigm: 46 Structural Cell Types Function as Environment‐Supporting Innate Immune Cells, With Endothelial and Vascular Smooth Muscle Cells as Key Prototypes

iNew Medicine, Volume 2, Issue 3, September 2026.
ABSTRACT The scope, organization, and biological significance of innate immune functions across structural cell types remain poorly defined. To address these fundamental knowledge gaps, we analyzed experimental data of transcriptomes generated by our group and others.
Juanjuan Liu, Gayani K. Nanayakkara, Yifan Lu, Fatma Saaoud, Keman Xu, Ying Shao, Bo Yuan, Shih‐Yu Hung, Haiyan Xiang, Xianwei Wang, Sadia Mohsin, Sheng Wu, Xiaolei Liu, Juncheng Wei, Zhengjie Zhou, Beata Kosmider, Mingui Fu, Laisel Martinez, Roberto Vazquez‐Padron, Wenhui Hu, Shuping Ge, Hong Wang, Xiaofeng Yang   +22 more
wiley   +1 more source

Severe Hyperlipidemia and Multifocal Atherosclerosis With Negative Genetic Testing for Familial Hypercholesterolemia: A Case Report. [PDF]

Cureus
Buczyński D, Róg A, Pałka M, Susuł M, Rajtar-Salwa R.   +4 more
europepmc   +1 more source

Inhibition of Tropomyosin Receptor Kinase B Signaling Alters Hepatic Mitochondrial Enzyme Activity and Oxidative Stress in Mice With Sucrose‐Induced Insulin Resistance

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.
Suppression of BDNF‐TrkB signaling has shown a protective trend on hepatic oxidative stress by reducing sucrose‐induced lipid peroxidation. BDNF–TrkB signaling pathway plays a peripheral role in regulating mitochondrial enzyme capacity and redox balance in the liver.
Akın Bodur, Hüseyin Çınar Zihni, Katip Korkmaz, Solmaz Bodur, Ahmet Alver   +4 more
wiley   +1 more source

Homozygous familial hypercholesterolemia, experience with Evinacumab treatment in two Mexican pediatric patients: case report. [PDF]

Front Genet
Madriz Prado R, Ríos Solís YG, Guerrero Dávila DE, Molina Fernández L, Aguilar Reyes OS, Ordóñez I, Ramos L, González M.   +7 more
europepmc   +1 more source

Genome Editing for Glycogen Storage Diseases

Journal of Inherited Metabolic Disease, Volume 49, Issue 5, September 2026.
ABSTRACT Gene therapy has been developed for several glycogen storage diseases and has advanced into clinical trials. However, the limitations of these gene therapies with regard to stability following treatment early in life have led to the development of genome editing.
Troy von Beck, Raymond Wang, Dwight Koeberl   +2 more
wiley   +1 more source

Impact of Early, Delayed, or Interrupted Treatment in Children With Familial Hypercholesterolemia. [PDF]

J Am Coll Cardiol
Huang YL, de Ferranti SD, Hartz J, Zhang Y, Ruiz-Negrón N, Kazi DS, Khera AV, Woo JG, Urbina EM, Jacobs DR, Allen NB, Wong JB, Moran AE, Bellows BK.   +13 more
europepmc   +1 more source

Cerebral Blood Transit in Sickle Cell Anemia

Journal of Magnetic Resonance Imaging, Volume 64, Issue 3, Page 738-750, September 2026.
ABSTRACT Background Sickle cell anemia (SCA) patients upregulate cerebral blood flow to compensate for decreased arterial oxygen content. Such hyperemic conditions can manifest as venous hyperintense signal on arterial spin labeling (ASL) MRI, which may reflect faster capillary blood transit, altered oxygen extraction fraction (OEF), and infarct risk ...
Wesley T. Richerson, Megan A. Aumann, Alexander K. Song, Samantha Davis, Lauren Milner, Maria Garza, Dann Martin, L. Taylor Davis, Sumit Pruthi, Lori C. Jordan, Manus J. Donahue   +10 more
wiley   +1 more source

A Genome-First Study of Familial Hypercholesterolemia Comparing African and European Ancestry Individuals. [PDF]

Circulation
Winters AH, Kelly MA, Syed MG, Bergquist T, Berry ASF, Mohammed N, Cawley D, Jones LK, Pejaver V, Gidding SS, Oetjens MT.   +10 more
europepmc   +1 more source

High‐Content CRISPR Screening: Methods and Applications

MedComm, Volume 7, Issue 9, September 2026.
High‐content CRISPR screening represents a paradigm shift in functional genomics, moving beyond traditional survival‐based readouts to enable multidimensional mapping of genotype–phenotype relationships. This review systematically outlines the methodological evolution of this approach, detailing advances in perturbation modalities, delivery systems ...
Yike Zhang, Yimeng Zhang, Xudong Tang, Xinyu Deng, Yitian Zhou, Yanfeng Wu, Jianhua Luo   +6 more
wiley   +1 more source