Results 201 to 210 of about 340,370 (339)

Functional genomics of Familial Hypercholesterolemia

, 2016
Main aim of the Portuguese Family Hypercholesterolemia study: to identify the cause of the dyslipidaemia in patients with a clinical phenotype of Familial Hypercholesterolaemia (FH)
Alves, Ana Catarina
core  

Therapeutic potential of okra (Abelmoschus esculentus) in dysglycaemia and metabolic dysfunction: A systematic review and meta‐analysis across the diabetes spectrum

Experimental Physiology, EarlyView.
Abstract The aim of this systematic review and meta‐analysis was to evaluate comprehensively the therapeutic potential of Abelmoschus esculentus (okra) supplementation across the diabetes spectrum of key metabolic risk factors. A search was conducted in PubMed, Scopus, Web of Science, EMBASE and the Cochrane Library, up to 23 July 2025, to identify ...
Ali Jafari, Helia Mardani, Mohammad Amin Karimi, MohammadHossein Sahami Gilan, Helia Hemmat, Fatemeh Shoja, Nooshin Enayati Soofi, Ghazaleh Eslamian   +7 more
wiley   +1 more source

First Revision of the Guidelines for the Diagnosis and Management of Remethylation Disorders

Journal of Inherited Metabolic Disease, Volume 49, Issue 4, July 2026.
ABSTRACT This guideline summarizes diagnostic and therapeutic approaches based on a systematic literature review and evidence evaluation using the GRADE methodology. Given the limited high‐quality data, expert consensus was additionally obtained through a modified Delphi process.
Giorgia Olivieri, Andrea Bordugo, Birute Burnyte, Alessandro Costetti, Maria‐Luz Couce, Luisa Diogo, Francois Feillet, D. Sean Froese, Benedetta Greco, Jean‐Louis Gueant, Luciana Hannibal, Friederike Hörster, Viktor Kožich, Giancarlo La Marca, Irini Manoli, Fanny Mochel, Lorenzo Orazi, Belén Pérez, Manuel Schiff, Bernd C. Schwahn, Ida Schwartz, Karolina M. Stepien, Jolanta Sykut‐Cegielska, Trine Tangeraas, Rolf H. Zetterström, Carlo Dionisi‐Vici, Martina Huemer   +26 more
wiley   +1 more source

Epoxy Clerodane Diterpene Attenuates the Differentiated Adipocyte Hypertrophy and Enhances Mitochondrial Metabolism

ChemistryOpen, Volume 15, Issue 7, July 2026.
Epoxy Clerodane Diterpene (ECD) significantly reduces adipocyte hypertrophy and lipid accumulation in human mesenchymal stem cell (hMSC)‐derived adipocytes. ECD improves mitochondrial membrane potential (ΔΨm), increases thermogenic regulators (UCP‐1, PPARγC1α), decreases adipogenic markers (C/EBPα, PPARγ), and reduces inflammatory mediators (TNF‐α, NF ...
Sahar Abdulaziz AlSedairy, Pandurangan Subash‐Babu, Maha H. Alhussain, Manal Abdulaziz Binobead, Ali A. Alshatwi   +4 more
wiley   +1 more source

Atherosclerosis at Warp Speed: The Urgent Lessons of Homozygous Familial Hypercholesterolemia. [PDF]

JACC Case Rep
Drossner D.
europepmc   +1 more source

Cognitive Functioning After Circulatory Shock: A Prospective Observational Study

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 6, July 2026.
ABSTRACT Background Cognitive impairment in intensive care unit (ICU) survivors is multifactorial and can affect especially memory, attention, and executive functions. This study aimed to determine the cognitive functioning of patients with circulatory shock immediately after ICU discharge and 3 months later.
Salla Laurila, Eva Nordenswan, Henriikka Ollila, Riikka Pihlaja, Erika Wilkman, Elina Varis, Maria Heliste, Sanna Koskinen, Annamari Tuulio‐Henriksson, Marjaana Tiainen, Heini Huhtala, Anne H. Kuitunen, Laura Hokkanen, Johanna Hästbacka   +13 more
wiley   +1 more source

Extracellular vesicles related to familial hypercholesterolemia. [PDF]

Arch Endocrinol Metab
Silvino JPP, Jannes CE, Pestana RMC, Silvino LPP, Silva IFO, Teixeira-Carvalho A, Gomes KB.   +6 more
europepmc   +1 more source

Cellular Heterogeneity During Arterial Aging

Aging Cell, Volume 25, Issue 7, July 2026.
Graphical abstract showing arterial cell subpopulations and their functional changes during aging. Transcriptomic profiling studies across species identify age‐associated endothelial, smooth muscle, fibroblast, and immune cell states characterized by inflammation, extracellular matrix remodeling, phenotypic switching, and cellular senescence ...
He Xu, Paul‐Lennard Mendez, Dimitri Kasakovski, Judith Sluimer   +3 more
wiley   +1 more source

CLINICAL GUIDELINES FOR FAMILIAL HYPERCHOLESTEROLEMIA

, 2019
These guidelines represent all current aspects of etiology, diagnosis, and treatment of the clinical and statistical group of familial hypercholesterolemia in both adults and children in accordance with the requirements of the Ministry of Health of ...
G. A. Konovalov, E. V. Shakhtshneider, V. O. Konstantinov, M. Yu. Shcherbakova, I. V. Sergienko, S. S. Bazhan, B. M. Lipovetsky, V. V. Kukharchuk, I. V. Leontyeva, A. N. Meshkov, M. I. Voevoda, I. N. Zakharova, A. I. Ershova, V. S. Gurevich, O. Yu. Aleksandrova, A. A. Sokolov, T. V. Balakhonova, A. E. Filippov, S. N. Pokrovsky, N. M. Akhmedzhanov, M. V. Ezhov   +20 more
core  

Genomic and Sex Contributions to Interindividual Variability in Pitavastatin Bioavailability

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 1, July 2026.
ABSTRACT Aim This study investigates pharmacogenetic determinants of pitavastatin disposition using a candidate‐gene approach. Methods In 48 healthy volunteers, 138 variants across 40 genes involved in drug metabolism and transport were analysed to assess their relationship with pitavastatin pharmacokinetics, alongside the influence of sex and ...
Eva González‐Iglesias, Sofía Moreno‐Pérez de Villar, Dolores Ochoa, Manuel Román, Jesús Novalbos, Samuel Martín‐Vilchez, Alejandro de Miguel, Francisco Abad‐Santos   +7 more
wiley   +1 more source