Results 201 to 210 of about 20,467 (242)
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Xanthomas in Familial Hypercholesterolemia
New England Journal of Medicine, 2017Two brothers presented to a primary care clinic with similar skin lesions and were found to have elevated LDL cholesterol levels. Family history helped make a diagnosis of familial hypercholesterolemia.
Amitabh, Poonia, Priya, Giridhara
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Genetics of Familial Hypercholesterolemia
Current Atherosclerosis Reports, 2015Familial hypercholesterolemia (FH) is a genetic disorder characterized by elevated low-density lipoprotein (LDL) cholesterol and premature cardiovascular disease, with a prevalence of approximately 1 in 200-500 for heterozygotes in North America and Europe. Monogenic FH is largely attributed to mutations in the LDLR, APOB, and PCSK9 genes. Differential
Brautbar, Ariel +5 more
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Familial hypercholesterolemia in children
Current Opinion in Lipidology, 2004This review provides an update on recent advances in the diagnosis and management of children with familial hypercholesterolemia.A large cross-sectional cohort study of paediatric familial hypercholesterolemia demonstrated that affected children had a 5-fold more rapid increase of carotid arterial wall intima-media thickness during childhood years than
J, Rodenburg +5 more
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Current Treatment Options in Cardiovascular Medicine, 2002
Heterozygous familial hypercholesterolemia is a common, severe form of elevated plasma, low-density lipoprotein (LDL) cholesterol. Familial hypercholesterolemia is under-recognized and under-treated despite well-known benefits from available lipid-lowering medications.
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Heterozygous familial hypercholesterolemia is a common, severe form of elevated plasma, low-density lipoprotein (LDL) cholesterol. Familial hypercholesterolemia is under-recognized and under-treated despite well-known benefits from available lipid-lowering medications.
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Heterozygous Familial Hypercholesterolemia
Circulation, 2016Familial hypercholesterolemia (FH) is a genetic condition that causes high low-density lipoprotein (LDL) cholesterol (sometimes referred to as bad cholesterol) from birth. FH means high cholesterol that runs in a family. FH is caused by specific DNA changes that are passed on from parents to their children. It is not caused by lifestyle factors such as
Angela, Onorato, Amy C, Sturm
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The inheritance of familial hypercholesterolemia
The American Journal of Medicine, 1972Abstract Several forms of familial hypercholesterolemia are now recognized. The most common is characterized by elevated serum cholesterol levels with normal or only modestly elevated serum triglyceride levels, currently classified as type II hyperlipoproteinemia.
J, Jensen, D H, Blankenhorn
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Familial hypercholesterolemia in pregnancy
Current Opinion in Endocrinology, Diabetes & ObesityPurpose of review Familial hypercholesterolemia (FH) in pregnancy poses several challenges, requiring a delicate balance between maternal atherosclerotic cardiovascular disease (ASCVD) risk and foetal safety.
Jayanthi, Ramanathan +4 more
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Familial hypercholesterolemia in Brazil
Atherosclerosis Supplements, 2003The Brazilian population has heterogeneous ethnic origins and is unevenly distributed in a country of continental dimensions. In addition to the Portuguese colonists until the end of the World War II Brazil received almost 5 million immigrants who settled mainly in the south and southeast.
J E, Dos Santos, M A, Zago
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Insulin sensitivity in familial hypercholesterolemia
Metabolism, 1993Insulin resistance is found in association with obesity, non-insulin-dependent diabetes mellitus, and essential hypertension, which are all risk factors for atherosclerotic cardiovascular disease. Furthermore, hyperinsulinemia has been reported in familial combined hyperlipoproteinemia and endogenous hypertriglyceridemia. Finally, relatively high serum
GALVAN AQ +7 more
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APOE and familial hypercholesterolemia
Current Opinion in LipidologyPurpose of review Autosomal dominant hypercholesterolemia is a common cause of cardiovascular disease. In addition to the classic genes that cause hypercholesterolemia, LDLR, APOB and PCSK9, a new locus has emerged as a candidate to be the cause of this hyperlipidemia, the p.(Leu167del) mutation in the APOE gene.
Civeira, Fernando +2 more
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