Results 31 to 40 of about 340,370 (339)

Prevalence of Severe Hypercholesterolemia and Familial Hypercholesterolemia Phenotype in Patients with Acute Coronary Syndrome

Medicina
Background and Objectives: Atherosclerotic cardiovascular disease is one of the most common causes of death and disability around the world. Hypercholesterolemia is an established and widely prevalent risk factor; however, the prevalence of severe ...
Urtė Aliošaitienė, Aleksandras Laucevičius, Urtė Smailytė, Egidija Rinkūnienė, Roma Puronaitė, Jūratė Barysienė, Žaneta Petrulionienė   +6 more
doaj   +2 more sources

Familial hypercholesterolemia

Annals of Medical Science and Research, 2022
Pankaj Singhania, Arunava Ghosh, Rana Bhattacharjee, Tapas Chandra Das   +3 more
doaj   +2 more sources

Guidelines for the Diagnosis and Treatment of Adult Familial Hypercholesterolemia 2022

Journal of atherosclerosis and thrombosis, 2023
Familial hypercholesterolemia (FH) is an autosomal hereditary disorder characterized by hyperLDL cholesterolemia (LDL-C), premature coronary artery disease (CAD), and tendon and skin xanthomas.
M. Harada‐Shiba, H. Arai, H. Ohmura, Hiroaki Okazaki, Daisuke Sugiyama, H. Tada, Kazushige Dobashi, K. Matsuki, T. Minamino, S. Yamashita, K. Yokote   +10 more
semanticscholar   +1 more source

Evinacumab for Pediatric Patients With Homozygous Familial Hypercholesterolemia

Circulation, 2023
BACKGROUND: Homozygous familial hypercholesterolemia (HoFH) is a rare genetic disorder characterized by severely elevated low-density lipoprotein cholesterol (LDL-C) levels due to profoundly defective LDL receptor (LDLR) function.
MD PhD Albert Wiegman, MD PhD Albert Wiegman, MD Susanne Greber-Platzer, PharmD Shazia Ali, MD M. Doortje Reijman, MD Eliot A Brinton, MD Min-Ji Charng, Pavithra Srinivasan, P. Md, Mph Seth Baum Md, M. Brothers, M. Hartz, M. P. M. Md, MD Jeanne Mendell, M. PhD, P. Banerjee, Patty George, M. Hirshberg, MD Robert Pordy   +18 more
semanticscholar   +1 more source

Thirty percent of children and young adults with familial hypercholesterolemia treated with statins have adherence issues

American Journal of Preventive Cardiology, 2021
Objective: To assess adherence to lipid lowering therapy (LLT), reasons for poor adherence, and achievement of LDL-C treatment goals in children and young adults with familial hypercholesterolemia (FH).
Gisle Langslet, Anja K. Johansen, Martin P. Bogsrud, Ingunn Narverud, Hilde Risstad, Kjetil Retterstøl, Kirsten B. Holven   +6 more
doaj   +1 more source

Efficacy, Safety, and Tolerability of Inclisiran in Patients With Homozygous Familial Hypercholesterolemia: Results From the ORION-5 Randomized Clinical Trial

Circulation, 2023
BACKGROUND: Homozygous familial hypercholesterolemia is a genetic disease characterized by extremely high levels of low-density lipoprotein cholesterol (LDL-C) and a high risk of premature cardiovascular events.
F. Raal, R. Durst, Ran Bi, Z. Tallóczy, Pierre Maheux, Anastasia Lesogor, John P. Kastelein   +6 more
semanticscholar   +1 more source

Guidelines for the Diagnosis and Treatment of Pediatric Familial Hypercholesterolemia 2022

Journal of atherosclerosis and thrombosis, 2023
As atherosclerosis begins in childhood, early diagnosis and treatment of familial hypercholesterolemia (FH) is considered necessary. The basic diagnosis of pediatric FH (under 15 years of age) is based on hyper-low-density lipoprotein (LDL ...
M. Harada‐Shiba, A. Ohtake, Daisuke Sugiyama, H. Tada, Kazushige Dobashi, K. Matsuki, T. Minamino, S. Yamashita, Yukiyo Yamamoto   +8 more
semanticscholar   +1 more source

Alirocumab and Coronary Atherosclerosis in Asymptomatic Patients with Familial Hypercholesterolemia: The ARCHITECT Study

Circulation, 2023
Background: The effect of alirocumab, a PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitor, on coronary plaque burden in patients with familial hypercholesterolemia has not been addressed.
L. Pérez de Isla, J. Díaz-Díaz, M. J. Romero, O. Muñiz-Grijalvo, J. Mediavilla, R. Argüeso, J. S. Sanchez Muñoz-Torrero, Patricia Rubio, P. Álvarez-Baños, P. Ponte, Dolores Mañas, L. Suárez Gutierrez, J. Cepeda, M. Casañas, F. Fuentes, C. Guijarro, Miguel Ángel Barba, A. Saltijeral Cerezo, T. Padró, P. Mata   +19 more
semanticscholar   +1 more source

Familial Hypercholesterolemia [PDF]

Cardiology Clinics, 2015
Familial hypercholesterolemia is a common, inherited disorder of cholesterol metabolism that leads to early cardiovascular morbidity and mortality. It is underdiagnosed and undertreated. Statins, ezetimibe, bile acid sequestrants, niacin, lomitapide, mipomersen, and low-density lipoprotein (LDL) apheresis are treatments that can lower LDL cholesterol ...
Victoria Enchia, Bouhairie, Anne Carol, Goldberg   +1 more
openaire   +3 more sources

Web-Based Tool (FH Family Share) to Increase Uptake of Cascade Testing for Familial Hypercholesterolemia: Development and Evaluation

JMIR Human Factors, 2022
BackgroundFamilial hypercholesterolemia, a prevalent genetic disorder, remains significantly underdiagnosed in the United States.
Hana Bangash, Ahmed Makkawy, Justin H Gundelach, Alexandra A Miller, Kimberly A Jacobson, Iftikhar J Kullo   +5 more
doaj   +1 more source