Results 31 to 40 of about 846,391 (207)

Geographical Distribution of the Most Frequent Mutations of Familial Mediterranean fever in the World [PDF]

Taṣvīr-i salāmat, 2016
Background and objectives: Familial Mediterranean Fever (FMF) is an autosomal recessive disease. Generally, the Mediterranean basin is the region where the first cases of FMF have been identified. The gene responsible for FMF is gene MEFV.
Soraya Hadi, Behrooz Sari Sarraf, Zhila Khamnian, Saeid Dastgiri   +3 more
doaj  

A Multifaceted Interplay Among Hemophagocytosis, Interleukin‐18, and Type I Interferon Distinguishes Still Disease From Other Autoinflammatory Diseases

Arthritis &Rheumatology, Volume 78, Issue 9, Page 1961-1974, September 2026.
Objective The unknown pathophysiology and the lack of specific features for systemic juvenile idiopathic arthritis and adult‐onset Still disease (collectively known as Still disease; SD) delay diagnosis and appropriate treatment. The goal of this study was to identify features and mechanisms that distinguish SD from other systemic autoinflammatory ...
Yvonne M. Mueller, Charlotte Girard, Harmen J. G. van de Werken, Stefan J. Erkeland, Dwin G. B. Grashof, Laurie Vaillant, Renske J. H. den Dekker, Iris van Zuijen, Sharon Veenbergen, Fanny Coffin, Eric Bindels, Yvan Jamilloux, Katerina Laskari, Vassili Soumelis, Bruno Fautrel, Cem Gabay, Peter D. Katsikis   +16 more
wiley   +1 more source

Exploratory Analysis of the Inhibitory Effects of Propranolol on NLRP3 and Pyrin Inflammasomes

ACR Open Rheumatology, Volume 8, Issue 8, August 2026.
Objective Propranolol, a nonselective beta receptor blocking agents, impacts cAMP levels and is commonly used to treat hypertension and hemangioma in children and adults. Although there are reports indicating its anti‐inflammatory properties, the exact mechanism is not fully understood. Methods Murine and human monocytes and macrophages were exposed to
Renske J. de Jong, Christopher T. Neullens, Aljoscha Swoboda, Melanie Saers, Philipp Berger, Sudheendra Hebbar Subramanyam, Anastasia Wiener, Kim Ohl, Ralf Weiskirchen, Heidi Noels, Tilmann Kallinich, Julia Guthrie, Christoph Kessel, Klaus Tenbrock   +13 more
wiley   +1 more source

A large pericardial effusion and bilateral pleural effusions as the initial manifestations of Familial Mediterranean Fever [PDF]

, 2015
Familial Mediterranean Fever (FMF) is a condition characterized by recurrent febrile poly-serositis. Typical presentations of the disease include episodes of fever, abdominal pain and joint pains. Chest pain is a less common presentation.
Mallia, Carmel, Mifsud, Simon, Cassar Demarco, Daniela, Coleiro, Bernard, Schembri, Emma Louise   +4 more
core  

Colchicine-and Clarithromycin-Induced Rhabdomyolysis in a Hemodialysis Patient with Familial Mediterranean Fever

Turkish Journal of Nephrology, 2019
Familial Mediterranean fever (FMF) is an autosomal recessive hereditary disease characterized by recurrent attacks of fever, usually accompanied by sterile polyserositis. Although colchicine is the main medical treatment option for FMF, potential adverse
Amir Hossein ABEDİ, Eray EROĞLU, İsmail KOÇYİĞİT, Aydın ÜNAL, Murat Hayri SİPAHİOĞLU, Bülent TOKGÖZ, Oktay OYMAK   +6 more
doaj   +1 more source

Heterozygous MEFV Mutation Leading to Renal Failure: A Case Study

Global Pediatric Health
Familial Mediterranean fever (FMF) is an autosomal recessive disorder, particularly common in the Mediterranean area. Mutations in the MEVF gene cause it. AA Amyloidosis is the most severe complication of FMF leading to chronic renal failure. We describe
Souhaila El Gazzane MD, Amine Ichane MD, Chaimae Nahi MD, Khadija Mouaddine MD, Bouchra Chkirate MD, PhD, Aziza Guennoun MD, Najat Oulahiane MD, Hassan Ait Ouamar MD, PhD, Lamiaa Rouas MD, PhD   +8 more
doaj   +1 more source

Sacroiliitis and Polyarteritis Nodosa in a Patient with Familial Mediterranean Fever

Case Reports in Medicine, 2016
Familial Mediterranean fever (FMF) is an autoinflammatory disorder with autosomal recessive inheritance, characterized by recurrent fever and episodes of serositis.
Yunus Ugan, Atalay Doğru, Hüseyin Şencan, Mehmet Şahin, Şevket Ercan Tunç   +4 more
doaj   +1 more source

Familial Mediterranean fever in two brothers aged seven and five years old [PDF]

Journal of Nephropathology
Familial Mediterranean fever (FMF) is an inherited disease characterized by fever and intermittent abdominal pain. Due to amyloid deposits in the kidneys and gastrointestinal tract, untreated FMF can lead to severe complications such as end-stage renal ...
Hedayat Heydarizadeh, Mohammad Moradi, Mojtaba Zare, Samaneh Tahmasebi Ghorabi, Seyed Hossein Hosseini   +4 more
doaj   +1 more source

The Multifaceted Role of Pyroptosis: Molecular Mechanisms, Crosstalk with Other Cell Death Pathways, and Therapeutic Implications

MedComm, Volume 7, Issue 7, July 2026.
Pyroptosis maintains immune homeostasis by eliminating damaged or infected cells, but its dysregulation promotes inflammation and cancer progression. The diagram illustrates key activation pathways, links with other programmed cell deaths, and cancer‐specific effects, enhancing its dual protective and pathogenic roles.
Diego Liviu Boaru, Patricia De Castro‐Martinez, Cielo Garcia‐Montero, Oscar Fraile‐Martinez, Majd N. Michael Alhaddadin, Silvestra Barrena‐Blázquez, Laura Lopez‐Gonzalez, Clara Tasende Fernández, Ricardo Alvarado‐Hurtado, Tomás Ratia Giménez, Inmaculada Lasa‐Unzúe, Manuel Díez Alonso, Alberto Gutiérrez‐Calvo, Miguel A. Saez, David Cobo‐Prieto, Jose V. Saz, Melchor Alvarez‐Mon, Raul Diaz‐Pedrero, Miguel A. Ortega   +18 more
wiley   +1 more source

Allergic but not autoimmune comorbidities in children with PFAPA: A nationwide matched case–control cohort study

Pediatric Allergy and Immunology, Volume 37, Issue 7, July 2026.
Abstract Background Periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) is the most common autoinflammatory syndrome of childhood. Although immune dysregulation is central to its pathogenesis, the broader burden of allergic and autoimmune comorbidities in PFAPA remains incompletely characterized.
Yackov Berkun, Eli Magen, Eugene Merzon, Ilan Green, Avivit Golan‐Cohen, Shlomo Vinker, Ariel Israel   +6 more
wiley   +1 more source