Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Konflik Pekerja-keluarga Dan Pengaruhnya Terhadap Kinerja Pegawai (Studi Kasus Rumah Sakit Berbasis Islam Di Surakarta) [PDF]
, 2016 This study aimed to identify: (1) the characteristic of work-family conflict (WFC) in Islamic based Hospital at Surakarta, (2) the cause of work-family conflict (WFC) in Islamic based Hospital at Surakarta. The locations of research are Rumah Sakit Islam
Irawati, Z. (Zulfa) +2 more
core
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
ANALISIS PENGARUH WORK FAMILY CONFLICT DAN FAMILY WORK CONFLICT TERHADAP INTENTION TO QUIT DENGAN BURNOUT SEBAGAI VARIABEL INTERVENING (Studi Pada Karyawan PT Telekomunikasi Indonesia Tbk. Wilayah Semarang Wilayah Semarang) [PDF]
, 2017 The aim of this study is to describe and analyze the influence of work family conflict and family work conflict on intention to quit with burnout as an intervening variable.
WULANSARI, Hesti, YUNIAWAN , Ahyar
core
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Women at work: work family conflict and well being [PDF]
, 2008 Many women have diverted from their traditional single role as home makers who are financially dependent on their husbands to the double roles of being home makers and wage earners.
Sandhu, Sarvinder Kaur
core
Relationship Between Work-Family Conflict, Job Embeddedness, Workplace Flexibility, and Turnover Intentions [PDF]
, 2017 The present study seeks to propose and test a research model that investigates job embeddedness as a mediator and workplace flexibility as a moderator of the effect of family-work conflict on turnover intentions.
Afsar, B. (Bilal), Rehman, Z. U. (Zia)
core +2 more sources
Neuroticism, work demands, work-family conflict and job stress consequences
Medycyna Pracy, 2014 Background: The objective of the study was to the determine of neuroticism, requirements of the labor market and work-family conflict while exploring consequences of various aspects of job stress in occupationally active parents.
Bogusława Halina Lachowska
doaj +1 more source
Family-friendly Policies Terhadap Work-family Conflict Serta Implikasinya Pada Komitmen Karyawan [PDF]
, 2013 The objectives of this study is to find out the influence of family-friendly policies on work-family conflict, the influence of work-family conflict on employee commitment, the influence of family-friendly policies on employee commitment, the ...
-, S. (SURVIVAL) +1 more
core +2 more sources