Results 121 to 130 of about 18,073,437 (258)
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Inter-Role Conflict Cycle: Family Distress in Work–Family Dynamics with Job and Home Demands
This study examined the longitudinal relationship between work–family conflict (WFC) and family–work conflict (FWC), with a focus on the moderating role of job demands and home demands, and the mediating role of family distress within dyads (i.e., actor [
Idris, Mohd Awang +1 more
core +1 more source
Relationships between Job Variables: The Moderating Effects of Support and the Mediating Effects of Job Satisfaction, Affective Commitment and Continuance Commitment in the Support Worker Industry [PDF]
, 2007 The factors associated with employees' work related attitudes and cognitions were examined. A sample of employees from Community Living Trust (CLT), an organisation within the disability support worker industry, completed a questionnaire that included ...
Botha, Hanlie
core
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Relationships between work-family conflict, gender-role attitude and job burnout
, 2015 Family and work are the two most important domains of life for most adults in not only developed but also developing countries. Role expectations of the individual in these two institutions are often incompatible.
Li, Y, Sun, Jianmin
core +1 more source
Molecular Oncology, EarlyView.LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David +12 more
wiley +1 more source
Work-family conflict and enrichment : a study of college coaches [PDF]
, 2008 textThe current work-family literature strongly emphasizes the conflict between the multiple roles that workers and parents assume. This conflict literature leaves readers with the impression that individuals are experiencing stress to a level that ...
Schenewark, Jarrod Denman
core
DanadyaksaThis study examines the effects of Work–Family Conflict and Family–Work Conflict on Job Satisfaction, with Work–Life Balance as a mediating variable among employees of PT. Wahyu Wisata Mandalika.
Maya Okyantari, Mukmin Suryatni
doaj +1 more source
Molecular Oncology, EarlyView.This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan +8 more
wiley +1 more source
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source