Results 111 to 120 of about 28,876,176 (297)

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Evaluating an Evidence-Based Intervention for Families and Survivors after Traumatic Brain Injury: The Brain Injury Family Intervention [PDF]

, 2008
The long-term detrimental impact of traumatic brain injury (TBI) on individuals and their family members is well known. However, there have been few standardized family interventions or findings from treatment efficacy studies to guide clinical practice.
Stejskal, Taryn M
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Effectiveness of family support-based companion video sharing to improve depression in perinatal maternity: a randomized controlled trial study protocol

Frontiers in Psychiatry
BackgroundThe importance of family support in addressing maternal anxiety and depression during pregnancy is widely recognized. However, cultural nuances and healthcare system dynamics in China call for tailored interventions for perinatal mental health.
Rantong Bao, Chenxin Yang, Ruijin Zhu, Wenzhuo Li, Yang Bai, Yang Jiang, Guoying Zhang   +6 more
doaj   +1 more source

Familias con Orgullo: Study protocol for an efficacy study of a family-based intervention for Hispanic sexual minority youth. [PDF]

PLoS One, 2023
Lozano A, Estrada Y, Scott D, Tapia MI, Santos HP, Carrico AW, Zolobczuk J, Manker A, Prado G.   +8 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

An evaluation of ‘Families for Health’ : a new family-based intervention for the management of childhood obesity [PDF]

Objectives - To develop and pilot a community-based family programme, ‘Families for Health’, for intervention with overweight and obese children aged 7-11 years.
Robertson, Wendy
core  

Promoting healthy sleep in Chinese kindergarteners through a family-based intervention: protocol of the "Healthy Sleep" randomised controlled trial. [PDF]

BMC Public Health, 2023
Zhang Z, Li L, Li X, Okely A.
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Family Club Denmark: A Quasi-Randomized Study of a Volunteer-Based Intervention to Support Vulnerable Families

Volunteer interventions play a vital role in supporting families by offering accessible and community-based resources outside the formal professional sector.
Maiken Pontoppidan, Arendse T. Larsen, Larsen, Arendse T., Friis-Hansen, Mette, Thorsager, Mette, Mette Friis-Hansen, Pontoppidan, Maiken, Mette Thorsager   +7 more
core   +1 more source