Results 131 to 140 of about 27,020,150 (302)

Supporting Youth and Families in Gaza: A Randomized Controlled Trial of a Family-Based Intervention Program. [PDF]

Int J Environ Res Public Health, 2022
Miller-Graff LE, Cummings EM.
europepmc   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Family-based intervention for adolescents with substance use disorders in Vietnam. [PDF]

Addict Behav Rep, 2021
Nguyen TT, Dinh TTT, Busse A, Kashino W, Suhartono S, Le MG.   +5 more
europepmc   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Brazilian Immigrant Parents' Preferences for Content and Intervention Modalities for the Design of a Family-Based Intervention to Promote Their Preschool-Age Children's Healthful Energy Balance-Related Behaviors. [PDF]

Int J Environ Res Public Health, 2023
Vilasboas T, Le Q, Greaney ML, Lindsay AC.   +3 more
europepmc   +1 more source

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source

Development of a Family-Based Prevention Model for Adolescent Mental Health Problems: A Socio-Ecological Approach in the Indonesian Context

Psychology Research and Behavior Management
Hesty Widyasih,1,2,* Nita Arisanti,3,* Veranita Pandia,4,* Meita Dhamayanti5,*1Doctoral Study Program in Medical Science, Faculty of Medicine, Universitas Padjadjaran, Sumedang, West Java, Indonesia; 2Departement of ...
Widyasih H, Arisanti N, Pandia V, Dhamayanti M   +3 more
doaj  

The Effectiveness of an eHealth Family-Based Intervention Program in Patients With Uncontrolled Type 2 Diabetes Mellitus (T2DM) in the Community Via WeChat: Randomized Controlled Trial. [PDF]

JMIR Mhealth Uhealth, 2023
Feng Y, Zhao Y, Mao L, Gu M, Yuan H, Lu J, Zhang Q, Zhao Q, Li X.   +8 more
europepmc   +1 more source

A web-based physical activity promotion intervention for inactive parent-child dyads: Protocol for a randomized controlled trial [PDF]

Background: Low levels of physical activity are associated with numerous adverse health outcomes, yet sedentary lifestyles are common among both children and adults.
Rhodes, Ryan, Hassandra, Mary, Ruiz, Montse C, Hamilton, Kyra, Hankonen, Nelli, Toivonen, Hanna-Mari, Kärkkäinen, Tommi, Chan, Derwin King, Aho, Reetta, Polet, Juho, Schneider, Jekaterina, Phipps, Daniel, Hagger, Martin, Kettunen, Eeva, Kykyri, Virpi Liisa, Green, Weldon Thomas, Kykyri, Virpi-Liisa, Knittle, Keegan, Toivonen, Hanna Mari, Laukkanen, Arto, Ruiz, Montse C., Lintunen, Taru, Sääkslahti, Arja, Biddle, Stuart, Aunola, Kaisa, Sääkslaht, Arja   +25 more
core   +1 more source