Results 131 to 140 of about 28,876,176 (297)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Journal of the Malta College of Family Doctors : volume 5 : issue 3 [PDF]

, 2016
MALLIA, P. - Graduation, specialisation and future initiatives -- GRECH, A., AXIAK, S., & GERADA, C. - The interphase between family medicine and mental health -- PULLICINO, G., PAVIA, J., ZINTILIS, S., FRANCALANZA, S., SCIORTINO, P., & SCIORTINO, P. -
Mallia, Pierre, Malta College of Family Doctors   +1 more
core  

A budget impact analysis of cost to implement a whole child health focused, family-based intervention in primary care for children with elevated BMI. [PDF]

Implement Sci Commun, 2023
Harris A, Jordan N, Carroll AJ, Graham AK, Wilson C, Wilson FA, Berkel C, Smith JD.   +7 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Transforming Coastal Household Sanitation: A Family-Centered PHAST Adaptation for Malnutrition and Environmentally Related Diseases-Vulnerable Communities

Unnes Journal of Public Health
Poor environmental sanitation in coastal areas is closely associated with environmentally related diseases and malnutrition among under-five children, but participatory interventions are rarely evaluated at the household level.
Evi Naria, Indra Chahaya, Rusmalawaty Rusmalawaty, Diza Hamzah, Syafrina Ulfah   +4 more
doaj   +1 more source

Family-based intervention for adolescents with substance use disorders in Vietnam. [PDF]

Addict Behav Rep, 2021
Nguyen TT, Dinh TTT, Busse A, Kashino W, Suhartono S, Le MG.   +5 more
europepmc   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Development of a Home-Based Holistic Dementia Nursing Intervention Model for Family Caregivers

Nurse Media: Journal of Nursing
Background: The number of older adults with dementia in Indonesia continues to increase. However, many family caregivers still have limited knowledge and skills, which can adversely affect both older adults and caregivers.
Rita Hadi Widyastuti, Junaiti Sahar, Etty Rekawati   +2 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Development of a Family-Based Prevention Model for Adolescent Mental Health Problems: A Socio-Ecological Approach in the Indonesian Context

Psychology Research and Behavior Management
Hesty Widyasih,1,2,* Nita Arisanti,3,* Veranita Pandia,4,* Meita Dhamayanti5,*1Doctoral Study Program in Medical Science, Faculty of Medicine, Universitas Padjadjaran, Sumedang, West Java, Indonesia; 2Departement of ...
Widyasih H, Arisanti N, Pandia V, Dhamayanti M   +3 more
doaj