Results 121 to 130 of about 27,020,150 (302)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

open access: yesMolecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu   +3 more
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

A budget impact analysis of cost to implement a whole child health focused, family-based intervention in primary care for children with elevated BMI. [PDF]

open access: yesImplement Sci Commun, 2023
Harris A   +7 more
europepmc   +1 more source

Calls to roll out family intervention programme.

open access: yes, 2016
Children were better prepared for starting school and parents made wiser use of the health service as a result of a family intervention programme trialled in a disadvantaged part of Dublin......
Shanahan, Catherine
core  

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

The design of an intervention to reduce violence in the family: A family–centred approach [PDF]

open access: yes, 2018
Philosophiae Doctor - PhDViolence occurs in different environments, however, it is often found in the family with family members being the perpetrators.
Ryan, Jill
core   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

open access: yesMolecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho   +2 more
wiley   +1 more source

Development of a Home-Based Holistic Dementia Nursing Intervention Model for Family Caregivers

open access: yesNurse Media: Journal of Nursing
Background: The number of older adults with dementia in Indonesia continues to increase. However, many family caregivers still have limited knowledge and skills, which can adversely affect both older adults and caregivers.
Rita Hadi Widyastuti   +2 more
doaj   +1 more source

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