Results 161 to 170 of about 1,077,598 (298)
Astrocyte heterogeneity in brain metastases
Molecular Oncology, EarlyView.Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver +2 more
wiley +1 more source
From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care
Molecular Oncology, EarlyView.Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard +8 more
wiley +1 more source
Family-Supportive Organizational Culture and Fathers' Experiences of Work-family Conflict in Sweden [PDF]
, 2011 This study explores fathers' experiences with work–family conflict and their perceptions of how supportive the organizational culture at work is regarding fathers' work–family needs, and whether a family-supportive organizational culture is associated ...
Allard, Karin, +2 more
core
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
Financial Stress, Family Conflict, and Youths' Successful Transition to Adult Roles [PDF]
We analyze the effect of mothers' and youths' reports of family financial stress and conflict on youths' transitions into adult roles. We find that mothers’ reports of financial stresses and borrowing constraints are associated with earlier transitions ...
Cobb-Clark, Deborah A., Ribar, David C.
core +3 more sources
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Work-Family Conflict, Balance and Enhancement [PDF]
Research into the relationship between employees’ professional and family lives began in the late 1970s and gained momentum following the seminal work of Greenhaus and Beutell (1985). This marked a shift from an exclusive focus on individual work domains
Xerri, Matt +2 more
core
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
Studia Universitatis Moldaviae: Stiinte ale Educatiei, 2017 Unul dintre conflictele motivaţionale întâlnite frecvent în mediul organizaţional este „conflictul familie-muncă”. Conflictul, în acest caz, derivă din nevoia de a integra în mod optim solicitările legate de rolul familial cu cele ale rolului profesional.
Carolina PLATON +9 more
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