Results 121 to 130 of about 1,613,013 (264)

The effect of family function on the self-acceptance of the broken home adolescent [PDF]

Broken-home adolescents tend to have a low level of self acceptance, then to achieve a high self-acceptance process, individuals need reinforcement from people in their surrounding environment, one of which is the family.
Azizah, Annisah Nurul, Prasetyaningrum, Susanti, Suryaningrum, Cahyaning   +2 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Family Functioning And Child Well-Being Amongst Urban Malay Single Mother Families Influence Of Risk And Protective Factors. [PDF]

, 2005
A large and growing number of Malaysian families with children are headed by single mothers. Past research has found that single mother families and their children experience more difficulties in the context of family life and well-being than two ...
K. Doshi, Anjli Panalal
core  

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Family and peer influences on adolescent psychological inflexibility: a regression mixture analysis

Frontiers in Psychology
IntroductionAdolescent mental health problems are closely linked to psychological inflexibility. Prior research has identified separate effects of family functioning and peer relationships on psychological inflexibility, but their combined effects ...
Lei Liu, Xiaomeng Hu, Mengyu Ma, Weilu Zhang, Biao Peng, Bixia Zhang, Xiaofang Luo   +6 more
doaj   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Problemas emocionales y comportamentales en los niños: asociación entre el funcionamiento familiar, la coparentalidad y la relación conyugal

Acta Colombiana de Psicología
Resumen El presente estudio tuvo como objetivo describir el funcionamiento familiar, la relación conyugal y la coparentalidad en familias, además de identificar las asociaciones entre estas variables con problemas emocionales y comportamentales en niños ...
Joseane De Souza, Maria Aparecida Crepaldi   +1 more
doaj   +1 more source