Results 111 to 120 of about 12,436,746 (396)
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
The Effect of Family History, Physical Activity, and Overweight on Type 2 Diabetes Mellitus in Elderly Iin Padang Bulan Community Health Center, Medan [PDF]
, 2018 Background: Diabetes mellitus is a global public health problem. In Indonesia, the prevalence of diabetes mellitus increased from 1.1% in 2007 to 2.1% in 2013. Prevalence of diabetes mellitus in North Sumatera was 2.3%. Medan ranked second highest with 2.
Nurmaini, N. (Nurmaini) +2 more
core
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Exploration of MedicineAim: It is unclear if individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) with family histories of ME/CFS differ from those with ME/CFS without this family history.
Leonard A. Jason, Sarah Ngonmedje
doaj +1 more source
Comparison of Family History and SNPs for Predicting Risk of Complex Disease
PLoS Genetics, 2012 The clinical utility of family history and genetic tests is generally well understood for simple Mendelian disorders and rare subforms of complex diseases that are directly attributable to highly penetrant genetic variants.
Chuong B. Do +3 more
semanticscholar +1 more source
How young people find out about their family history of Huntington's disease [PDF]
, 2009 Family communication about adult-onset hereditary illness can be problematic, leaving some relatives inadequately informed or ignorant of their risk.
Forrest Keenan, Karen +4 more
core +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Frontiers in MedicineIntroductionPsoriasis, a chronic inflammatory skin disease, is believed to be influenced by both genetic and environmental factors. Despite this understanding, the clinical epidemiological status of psoriasis patients with a family history of the disease
Lu Cao +9 more
doaj +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source