Results 121 to 130 of about 4,131,311 (354)
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
Difficulties in the delivery of high quality family medicine [PDF]
, 1993 Many young people find medicine fascinating and a challenging career due to the attraction of dealing with a subject relating to life and death and major life incidents, as well as having the opportunity to get to know people over a long period through ...
Martin, Edwin E.J.
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Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Quality of Care Assessment at a Resident-based Primary Care HIV Clinic [PDF]
, 2016 A quality improvement study based in a primary care resident-based HIV clinic, the Kendig Clinic, was conducted within Jefferson Family Medicine Associates.
Lacue, Amanda, Miller, MD, Marshall
core +1 more source
Academic Medicine, 1976 The relatively new specialty, family practice, has stimulated a renewed interest in personal, comprehensive care of the entire family. This approach to patient care is derived from the general practice tradition. The development of family practice as a specialty occurred at the end of a long period of decline in general practice.
openaire +3 more sources
Molecular Oncology, EarlyView.Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard +12 more
wiley +1 more source
Global competencies in family medicine [PDF]
, 2010 Introduction:This project was devised to provide a global snapshot of required national competencies in Family Medicine, and is the result of an international collaboration of the International Fellowship of Primary Care Research Networks (IFPCRN).
Cayley, William E +4 more
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CALLING ALL SCHOLARS TO THE COUNCIL OF ACADEMIC FAMILY MEDICINE EDUCATIONAL RESEARCH ALLIANCE (CERA) [PDF]
, 2011 Navkiran K. Shokar +8 more
openalex +1 more source