Results 161 to 170 of about 4,182,366 (344)
A “Marginalized Part of Adolescent Healthcare”: Emergency Contraception Training Experiences Among Residents in Pediatrics, Family and Emergency Medicine [PDF]
, 2016 Amber Truehart +3 more
openalex +1 more source
Assess personal, health system, and geosocial risk factors for no-shows among patients in family medicine clinics [PDF]
, 2023 Wen‐Jan Tuan +2 more
openalex +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
, 2015 Family medicine, even though probably the oldest form of medicine, is a recent but rapidly expanding branch on the complex tree of medical specialties. Most countries in the world have a system of family medicine, but varieties are large. This entry shows that its position within the ordinary lives of people and some of its central tenets, especially ...
openaire +1 more source
Hypoglycaemia among adults with Type 2 Diabetes mellitus in a Family Medicine Clinic
, 2021 OO Sodipo +4 more
openalex +2 more sources
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source