Results 111 to 120 of about 13,953,274 (395)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Family violence across the life cycle [PDF]

Aims to address clinical questions that general practitioners (GPs) may have in identifying and responding to patients experiencing family violence. Background Family violence covers a range of abuse including child abuse and neglect, intimate partner ...
Elizabeth Hindmarsh, Kelsey Hegarty, Kirsty Forsdike, Laura Tarzia   +3 more
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Engaging fathers in preventive services: fathers and family centres [PDF]

, 2000
Although many fathers are spending more time caring for their children in the home, men continue to be conspicuous by their absence from mainstream family support services.
Ghate, D, Hazel, N, Shaw, C
core  

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Diagnostic accuracy of artificial intelligence compared to family physicians and dermatologists for skin conditions: a systematic review and meta-analysis

BMC Primary Care
Context Artificial intelligence (AI) technologies are increasingly used for image recognition, especially for skin lesions. Due to what may be long wait times for dermatology appointments, general practitioners (GPs) are the gatekeepers when it comes to ...
Norhane Nadour, Théo Duguet, Sophie Zahedi, Hugo Figoni, Roxane Liard   +4 more
doaj   +1 more source

Work as a social risk factor in pregnancy: A systematic review of screening practices related to working conditions and family leave among pregnant adults

, 2022
Julia M. Goodman, Mina Colon, Erika Cottrell, Jeanne‐Marie Guise   +3 more
openalex   +2 more sources

Adaptação cultural e validação da versão brasileira da Family Nursing Practice Scale (FNPS) para a população de enfermeiros do contexto hospitalar [PDF]

, 2020
Willian da Silva Rodrigues
openalex   +1 more source

The family in the practices of Family Health teams

Revista Brasileira de Enfermagem, 2014
Exploratory, qualitative study, that aimed to analyze the "centrality in the family", a Family Health Strategy (FHS) attribute, examining how the family context is considered in the practice of health professionals, through the analysis of health practices directed to families in Manaus-AM, Brazil.
Nair Chase, da Silva, Ligia, Giovanella, Evelyne Marie Therese, Mainbourg   +2 more
openaire   +2 more sources