Results 111 to 120 of about 8,832,657 (301)
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Background: Despite the increasing variety of options and advancements in efficacy of contraceptive methods, unintended pregnancy is still prevalent.
Default Account, Family Practice Resident +2 more
core +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Family Physicians’ Knowledge, Perceptions and Practices Regarding Frailty in British Columbia
INTRODUCTION: Frailty is an evolving state of increased vulnerability and functional impairment due to cumulative declines across multiple body systems.
Default Account, Family Practice Resident
core
, 2014 Contents: Specialisation and training - Pierre MalliaJournal of the Malta College of Family Doctors The mission of the Journal of the Malta College of Family Doctors (JMCFD) is to deliver accurate, relevant and inspiring research, continued medical ...
Mallia, Pierre +1 more
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Burnout amongst Family Practice Residents
, 2015 Introduction: Burnout is characterized by the loss of emotional, mental, and physical energy due to continued job-related stress. It is a syndrome of depersonalization, emotional exhaustion, and a sense of low personal accomplishment that leads to ...
Mussell, Broncyn, Grootendorst, Martin
core +1 more source
Socioeconomic determinants of health (SDH) contribute significantly to health outcomes. Those with lower socioeconomic status face higher mortality rates. There is limited literature available in this area currently.
Ellis , Hanna +2 more
core +1 more source