Results 81 to 90 of about 4,660,425 (301)

Patient perspectives on stress after ICU and a short primary care based psychological intervention – results from a qualitative sub‑study of the PICTURE trial

BMC Primary Care
Background Approximately 20–25% of patients who survive medical treatment at an intensive care unit (ICU) develop post-traumatic stress symptoms. There is currently a gap in follow-up care for them.
Antina Beutel, Linda Sanftenberg, Chris M. Friemel, Robert Philipp Kosilek, Maggie Schauer, Thomas Elbert, Ulf-Dietrich Reips, Tomke Schubert, Sabine Gehrke-Beck, Konrad Schmidt, Jochen Gensichen, for the PICTURE study group   +11 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Dealing with health literacy at the organisational level, French translation and adaptation of the Vienna health literate organisation self-assessment tool

BMC Health Services Research, 2019
Background Efforts to address health literacy should favour a system-based approach with the dual aim both of fostering the material conditions and creating a work culture inside health care organisations that makes it easier for people to use ...
Gilles Henrard, Marc Vanmeerbeek, Laetitia Buret, Jany Rademakers   +3 more
doaj   +1 more source

Autonomy versus futility? Barriers to good clinical practice in end-of-life care: a Queensland case [PDF]

, 2012
Findings from a Queensland coronial inquest highlight the complex clinical, ethical and legal issues that arise in end-of-life care when clinicians and family members disagree about a diagnosis of clinical futility.
Lawrence, Sean, Milligan, Eleanor, Parker, Malcolm, White, Ben, Willmott, Lindy, Winch, Sarah   +5 more
core   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

German general practitioners’ self-reported management of patients with chronic depression

BMC Psychiatry, 2017
Background Patients with chronic depression (persisting symptoms for ≥2 years) are a clinically relevant group with extensive (co)morbidity, high functional impairment and associated costs in primary care. The General Practitioner (GP) is the main health
Florian Wolf, Antje Freytag, Sven Schulz, Thomas Lehmann, Susann Schaffer, Horst Christian Vollmar, Thomas Kühlein, Jochen Gensichen   +7 more
doaj   +1 more source

Broadening Our Perspective on Spirituality and Coping among Women with Breast Cancer and their Families: Implications for Practice [PDF]

, 2007
The purpose of this paper is to illustrate the role of spirituality in coping among women with breast cancer and their families. This phenomenological study was guided by family systems theory and the recognition that a family is a complex system whereby
Schneider, Margaret A.
core   +3 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Diagnostic accuracy of artificial intelligence compared to family physicians and dermatologists for skin conditions: a systematic review and meta-analysis

BMC Primary Care
Context Artificial intelligence (AI) technologies are increasingly used for image recognition, especially for skin lesions. Due to what may be long wait times for dermatology appointments, general practitioners (GPs) are the gatekeepers when it comes to ...
Norhane Nadour, Théo Duguet, Sophie Zahedi, Hugo Figoni, Roxane Liard   +4 more
doaj   +1 more source