Results 11 to 20 of about 45,579 (198)

Subtherapeutic dose lithium treatment induces behavioral and neuropathological changes in 3xTg‐AD Alzheimer's mice [PDF]

Alzheimer's &Dementia, Volume 21, Issue S1, December 2025.
Abstract Background Alzheimer's disease (AD) is the most common cause of dementia and a global health challenge. The efficacy of lithium salts in stabilizing moods and neuroprotective effects has stimulated research into their use in neurodegenerative diseases.
Monique Patricio Singulani, Rosana Camarini, Leda Leme Talib, Luiz Roberto Britto, Orestes Vicente Forlenza   +4 more
wiley   +2 more sources

An interleukin-33/ST2 signaling deficiency reduces overt pain-like behaviors in mice [PDF]

, 2013
Interleukin (IL)-33, the most recent member of the IL family of cytokines, signals through the ST2 receptor. IL-33/ST2 signaling mediates antigen challenge-induced mechanical hyperalgesia in the joints and cutaneous tissues of immunized mice. The present
Alves-Filho, J.C., Casagrande, R., Cunha, F.Q., Cunha, T.M., Ferreira, S.H., Hohmann, M.S.N., Liew, F.Y., Magro, D.A.C., Mizokami, S.S., Verri Jr, W.A.   +9 more
core   +3 more sources

Synthesis of 2-Methyl-3-indolylacetic Derivatives as Anti-Inflammatory Agents That Inhibit Preferentially Cyclooxygenase 1 without Gastric Damage [PDF]

, 2006
Novel substituted 2-methyl-3-indolylacetic derivatives were synthesized and evaluated for their activity in vitro and in vivo on COX-1 and COX-2. Active compounds were screened to determine their gastrointestinal tolerability in vivo in the rat.
C. Renner, CALIENDO, GIUSEPPE, CIRINO, GIUSEPPE, FIORINO, FERDINANDO, PERISSUTTI, ELISA, ROSSI, ANTONIETTA, ROVIEZZO, FIORENTINA, SANTAGADA, VINCENZO, SAUTEBIN, LIDIA, SEVERINO, BEATRICE   +9 more
core   +1 more source

Modulation of Cox-1, 5-, 12- and 15-Lox by popular herbal remedies used in southern Italy against psoriasis and other skin diseases. [PDF]

, 2014
Acanthus mollis (Acanthaceae), Achillea ligustica, Artemisia arborescens and Inula viscosa (Asteraceae) are used in Southern Italy against psoriasis and other skin diseases that occur with an imbalanced production of eicosanoids.
Amenta, Ammon, Bader, Brand-Williams, Bremner, Bruni, Bruno, Charlier, Dehmlow, DiSepio, Flora, Glaser, Henke, Iversen, Luper, Mosmann, Pannala, Safayhi, Safayhi, Serhan, Spector, Sun, Tornhamre, Tzakou, Voorhees, Wang, Yamamoto   +26 more
core   +1 more source

O universo cultural e científico valenciano durante os séculos XIII e XIV e a contextualização da obra de Arnaldo de Vilanova Valencia's cultural and scientific universe in the thirteenth and fourteenth centuries and the contextualization of Arnaldo de Vilanova's work

História, Ciências, Saúde: Manguinhos, 1996
O presente artigo enfoca a singularidade do pensamento médico de Arnaldo de Vilanova em comparação com o que prevalecia entre seus contemporâneos no continente europeu no século XIII.
Ana Maria Alfonso-Goldfarb, Maria A. Pileggi Perassollo   +1 more
doaj   +1 more source

Synthesis, in vitro, and in vivo biological evaluation and molecular docking simulations of chiral alcohol and ether derivatives of the 1,5-diarylpyrrole scaffold as novel anti-inflammatory and analgesic agents. [PDF]

, 2008
Following our previous research on anti-inflammatory drugs (NSAIDs), we report here the synthesis of chiral 1,5-diarylpyrroles derivatives that were characterized for their in vitro inhibitory effects toward cyclooxygenase (COX) isozymes.
ANZELLOTTI P., ANZINI M., BIAVA M., BOTTA M., CIRILLI R., FERRETTI R., FORLI ., GALLINELLA B., GHELARDINI C., GIORDANI A., LA TORRE F., MAKOVEC F., MANETTI F., NORCINI M., PATRIGNANI P., PERGOLA C., POCE G., PORRETTA G. C., ROSSI, ANTONIETTA, SAUTEBIN, LIDIA, SUPINO S.   +20 more
core   +1 more source

Uso de dexmedetomidina em anestesia pediátrica

Revista de Medicina da UFC, 2023
Objetivo: A presente pesquisa tem como objetivo fazer uma revisão a respeito do uso de dexmedetomidina (DEX) na sedação pediátrica. Metodologia: Realizou-se a coleta de 11 artigos que tratam da temática, em seguida analisou-se aspectos da respectiva ...
Lucas Giannini de Oliveira Conrado Arruda, Lorena Antônia Sales de Vasconcelos Oliveira, Pablo Stevan Barbosa de Carvalho   +2 more
doaj   +1 more source

Algunas consideraciones sobre la enseñanza de la Farmacología en la carrera de Estomatología en Cuba

Edumecentro, 2021
Introducción: la Farmacología constituye el sustento científico de la terapéutica medicamentosa abordada en las asignaturas clínicas en la carrera de Estomatología, lo cual justifica su inclusión en los planes de estudios y pone de manifiesto la ...
Ana Ibis Bosch Nuñez
doaj  

Reactivation of wild-type and mutant p53 by tryptophanolderived oxazoloisoindolinone SLMP53-1:a novel anticancer small-molecule [PDF]

, 2015
Restoration of the p53 pathway, namely by reactivation of mutant (mut) p53, represents a valuable anticancer strategy. Herein, we report the identification of the enantiopure tryptophanol-derived oxazoloisoindolinone SLMP53-1 as a novel reactivator of ...
Bessa, Cláudia, Bisio, Alessandra, Fernandes, João, Gomes, Célia, Gomes, Sara, Gonçalves, Jorge, Inga, Alberto, Monteiro, Ângelo, Pereira, Clara, Pereira, Nuno A.L., Queiroz, Glória, Raimundo, Liliana, Reis, Flávio, Santos, Maria M.M., Saraiva, Lucília, Soares, Joana   +15 more
core   +3 more sources

Tratamiento farmacológico de la emergencia Hipertensiva

Medimay, 2014
Se presenta la emergencia hipertensiva desde varios puntos de vista. Se define la entidad, se abordaron las diferentes formas de presentación así como las causas que la producen.
Antonio Ariel Gutiérrez Alvarez, Eider G. Hernández Correa, Lázaro A. Díaz Pérez   +2 more
doaj   +4 more sources