Results 111 to 120 of about 114,798 (264)

Non-genomic effects of nuclear receptors: insights from the anucleate platelet [PDF]

, 2018
Nuclear receptors have the ability to elicit two different kinds of responses, genomic and non-genomic. While genomic responses control gene expression by influencing the rate of transcription, non-genomic effects occur rapidly and independently of ...
Ahmadian, Ahuja, Ajayi, Ajjan, Akarasereenont, Akbiyik, Ali, Ali, Ali, Amanda J Unsworth, Badimon, Bain, Bar, Beckman, Bishop-Bailey, Bledsoe, Boilard, Boonyaratanakornkit, Borsig, Burris, Bye, Calkin, Campelo, Cecchetti, Cesario, Chinetti, Cumhur Cure, Dolle, Du, Duong, El Haouari, Evans, Falkenstein, Filippatos, Frye, Gabbi, Gagan D Flora, Ghasri, Güncü, Hammes, Hankey, Hellgren, Huang, Johnson, Johnson, Jonathan M Gibbins, Jones, Kadmiel, Kato, Kersten, Khan, Khetawat, Kiss, Krasowski, Kwon, Layton, Lee, Li, Liverani, Losel, Makishima, Matsuda, Maximov, McKenna, Mencarelli, Moraes, Moraes, Moraes, Moraes, Moraes, Morrell, Muchmore, Murphy, Nadal, Nathan, Ng, Njar, Noy, Ordóñez-Morán, Overington, Pilo, Richard, Risitano, Rondina, Rowley, Santilli, Sato, Schaffer, Schneider, Schubert, Schulz, Schwertz, Sepe, Sidhu, Silvagno, Spyridon, Sundahl, Trayhurn, Unsworth, Unsworth, Unsworth, Unsworth, Valera, Walmsley, Wang, Wu‐Wong, Wójcicka, Xu, Zimmerman   +108 more
core   +2 more sources

Mutations in the nuclear bile acid receptor FXR cause progressive familial intrahepatic cholestasis

Nature Communications, 2016
Neonatal cholestasis is a result of elevated bile acid levels, and is associated with mutations in genes regulating bile acid homeostasis. Here the authors identify mutations in the bile acid sensing farnesoid X receptor in four individuals with neonatal
Natalia Gomez-Ospina, Carol J. Potter, Rui Xiao, Kandamurugu Manickam, Mi-Sun Kim, Kang Ho Kim, Benjamin L. Shneider, Jennifer L. Picarsic, Theodora A. Jacobson, Jing Zhang, Weimin He, Pengfei Liu, A. S. Knisely, Milton J. Finegold, Donna M. Muzny, Eric Boerwinkle, James R. Lupski, Sharon E. Plon, Richard A. Gibbs, Christine M. Eng, Yaping Yang, Gabriel C. Washington, Matthew H. Porteus, William E. Berquist, Neeraja Kambham, Ravinder J. Singh, Fan Xia, Gregory M. Enns, David D. Moore   +28 more
doaj   +1 more source

Genetically predicted KIR2DS4 mediate the association between gut microbe K10 and osteoporosis fractures: A mediation Mendelian randomization study

PM&R, EarlyView.
Abstract Background Osteoporosis fractures pose a significant public health concern, leading to substantial morbidity and mortality rates. The emerging evidence on the potential link between gut microbiota, proteins, and osteoporosis fractures suggests a complex relationship that warrants further investigation.
Qiong Wang, Qing Kuang, Cheng Chen, Binru Wang, Wei Xiang, Xinming Li, Jianjiao Mou   +6 more
wiley   +1 more source

Functional constraints on the constitutive androstane receptor inferred from human sequence variation and cross-species comparisons [PDF]

, 2005
Members of the NR1I subfamily of nuclear receptors play a role in the transcriptional activation of genes involved in drug metabolism and transport. NR1I3, the constitutive androstane receptor (CAR), mediates the induction of several genes involved in ...
Di Rienzo Anna, Krasowski Matthew D, Kuttab-Boulos Hala, Thompson Emma E   +3 more
core   +2 more sources

Activation of the Farnesoid X Receptor (FXR) Suppresses Linoleic Acid-Induced Inflammation in the Large Yellow Croaker (Larimichthys crocea).

Journal of NutriLife, 2020
BACKGROUND High linoleic acid (LA) intake leads to inflammation that adversely influences health in fish. However, whether the farnesoid X receptor (FXR) could be an effective target for regulating LA-induced inflammation remains unknown. OBJECTIVE The
Jianlong Du, Qiang Chen, Yongnan Li, Xiaojun Xiang, W. Xu, K. Mai, Q. Ai   +6 more
semanticscholar   +1 more source

Farnesoid X receptor prevents hyperuricemia via activating ATP‐binding cassette subfamily G member 2

Rheumatology &Autoimmunity, EarlyView.
Farnesoid X receptor (FXR) activation reduces serum uric acid levels by upregulating the intestinal urate transporter ATP‐binding cassette subfamily G member 2 (ABCG2). These findings uncover a novel metabolic pathway for urate excretion and suggest that FXR agonists (e.g., obeticholic acid), represent a promising therapeutic strategy for the treatment
Rui Li, Guo Tang, Ye Yu, Guang‐Liang Chen, Liangjing Lu, Juan Wang   +5 more
wiley   +1 more source

Origin and diversification of steroids: Co-evolution of enzymes and nuclear receptors [PDF]

, 2010
Recent sequencing of amphioxus and sea urchin genomes has provided important data for understanding the origins of enzymes that synthesize adrenal and sex steroids and the receptors that mediate physiological response to these vertebrate steroids ...
Michael E. Baker
core   +1 more source

Dose-related liver injury of Geniposide associated with the alteration in bile acid synthesis and transportation. [PDF]

, 2017
Fructus Gardenia (FG), containing the major active constituent Geniposide, is widely used in China for medicinal purposes. Currently, clinical reports of FG toxicity have not been published, however, animal studies have shown FG or Geniposide can cause ...
Feng, Xiaoyi, Gao, Yue, Han, Jiayin, La Frano, Michael R, Li, Chunying, Li, Guiqin, Li, Xiaolong, Liang, Aihua, Liu, Jing, Newman, John W, Pan, Chen, Tian, Jingzhuo, Wang, Lianmei, Xiang, Shixie, Yi, Yan, Zhang, Yushi, Zhao, Yong, Zhu, Jingjing   +17 more
core   +2 more sources

Farnesoid X receptor activation induces antitumour activity in colorectal cancer by suppressing JAK2/STAT3 signalling via transactivation of SOCS3 gene

Journal of Cellular and Molecular Medicine, 2020
Farnesoid X receptor (FXR, encoded by NR1H4), a bile acid‐activated nuclear receptor, is widely implicated in human tumorigenesis. The FXR agonist obeticholic acid (OCA) has preliminarily displayed tumour suppressor potential.
Shan Li, Zhengshui Xu, Jing-Yue Guo, Jianbao Zheng, Xuejun Sun, Junhui Yu   +5 more
semanticscholar   +1 more source

Farnesoid X receptor: A “homeostat” for hepatic nutrient metabolism

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2018
The Farnesoid X receptor (FXR) is a nuclear receptor activated by bile acids (BAs). BAs are amphipathic molecules that serve as fat solubilizers in the intestine under postprandial conditions. In the post-absorptive state, BAs bind FXR in the hepatocytes, which in turn provides feedback signals on BA synthesis and transport and regulates lipid, glucose
Massafra, Vittoria, van Mil, Saskia W C
openaire   +3 more sources