Downregulation of intestinal Farnesoid X Receptor in Erythropoietic protoporphyria [PDF]
, 2017 Erythropoietic protoporphyria (EPP) is characterized by accumulation of protoporphyrin IX (PPIX) in the body. The liver is the major organ responsible for PPIX excretion through the biliary system. Because PPIX is highly hydrophobic, an excess amount of
Pradhan, Komal
core
Intracellular cholesterol transporters and modulation of hepatic lipid metabolism: implications for diabetic dyslipidaemia and steatosis [PDF]
, 2014 Caridis, Anna-Maria +3 more
core +1 more source
Bile acid retention and activation of endogenous hepatic farnesoid-X-receptor in the pathogenesis of fatty liver disease in ob/ob-mice [PDF]
, 2017 The nuclear bile acid receptor FXR (farnesoid-X-receptor) has recently been implicated in the pathophysiology of non-alcoholic fatty liver disease because selective FXR-agonists improve glucose and lipid metabolism in rodent models of obesity.
Geier, Andreas +6 more
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A variant of FGF19 for treatment of disorders of cholestasis and bile acid metabolism. [PDF]
, 2015 Appleby, RN, Walters, JR
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Impact of Bile Acid Amidation on In Silico Farnesoid X Receptor Dynamics. [PDF]
J Phys Chem BEisert-Sasse RK, Biswas A, Okafor CD.
europepmc +1 more source
Tamoxifen induced hepatotoxicity via gut microbiota-mediated hyodeoxycholic acid depletion and Farnesoid X receptor signaling disruption. [PDF]
Gut MicrobesChen Y +15 more
europepmc +1 more source
Obeticholic Acid and Other Farnesoid-X-Receptor (FXR) Agonists in the Treatment of Liver Disorders. [PDF]
Pharmaceuticals (Basel)Fiorucci S +3 more
europepmc +1 more source