Results 121 to 130 of about 16,980 (251)

Response of Staphylococcus epidermidis biofilms cells to the effect of farnesol [PDF]

, 2010
Objective:Staphylococcus epidermidis is a leading cause of medical-device-related infections, especially in immunocompromised patients. The treatment of these infections is further complicated by the emergence of multiresistant strains. The ability of S.
Gomes, F. I., Leite, Bruna, Oliveira, Rosário, Pizzolitto, Elisabeth, Teixeira, P.   +4 more
core  

Farnesol Has an Anti-obesity Effect in High-Fat Diet-Induced Obese Mice and Induces the Development of Beige Adipocytes in Human Adipose Tissue Derived-Mesenchymal Stem Cells

Frontiers in Pharmacology, 2017
Brown adipocytes dissipate energy as heat and hence have an important therapeutic capacity for obesity. Development of brown-like adipocytes (also called beige) is also another attractive target for obesity treatment.
Hye-Lin Kim, Yunu Jung, Yunu Jung, Jinbong Park, Dong-Hyun Youn, Dong-Hyun Youn, JongWook Kang, JongWook Kang, Seona Lim, Beom Su Lee, Mi-Young Jeong, Seong-Kyu Choe, Raekil Park, Kwang Seok Ahn, Jae-Young Um   +14 more
doaj   +1 more source

Insights into Candida world: the extracellular milieu [PDF]

, 2010
Over the last years Candida species, including Candida albicans, Candida dubliniensis, Candida glabrata, Candida krusei, Candida parapsilosis, and Candida tropicalis, have emerged as significant pathogens.
Henriques, Mariana, Martins, Margarida Isabel Barros Coelho, Oliveira, Rosário   +2 more
core  

The effect of Farnesol on sensitivity of microorganisms from bacterial-fungal biofilm to antimicrobial agents in vitro

RUDN Journal of Agronomy and Animal Industries
Two microorganisms Staphylococcus aureusandCandida albicansisolated from a mixed bacterial-fungal biofilm of horse wound were studied. Resistance profile of these clinical strains to antimicrobial agents was determined using standard disc diffusion ...
Nadezhda P. Sachivkina, Oksana V. Nechet, Iman S. Gashimova, Diana V. Kondrateva, Nikolay V. Sakhno   +4 more
doaj   +1 more source

Dietary geranylgeraniol can limit the activity of pitavastatin as a potential treatment for drug-resistant ovarian cancer [PDF]

, 2017
Pre-clinical and retrospective studies of patients using statins to reduce plasma cholesterol have suggested that statins may be useful to treat cancer. However, prospective clinical trials have yet to demonstrate significant efficacy. We have previously
Abdullah, MI, de Wolf, E, Drijfhout, FP, Hart, S, Hoskins, C, Jones, SM, Menezes, K, Moss, DM, Richardson, A, Stronach, EA   +9 more
core   +2 more sources

Extracting the Behaviorally Relevant Stimulus: Unique Neural Representation of Farnesol, a Component of the Recruitment Pheromone of Bombus terrestris.

PLoS ONE, 2015
To trigger innate behavior, sensory neural networks are pre-tuned to extract biologically relevant stimuli. Many male-female or insect-plant interactions depend on this phenomenon.
Martin F Strube-Bloss, Austin Brown, Johannes Spaethe, Thomas Schmitt, Wolfgang Rössler   +4 more
doaj   +1 more source

Zoledronic acid treatment impairs protein geranyl-geranylation for biological effects in prostatic cells [PDF]

, 2006
BACKGROUND: Nitrogen-containing bisphosphonates (N-BPs) have been designed to inhibit osteoclast-mediated bone resorption. However, it is now accepted that part of their anti-tumor activities is related to interference with the mevalonate pathway ...
M Goffinet, M Thoulouzan, A Pradines, I Lajoie-Mazenc, Carolyn Weinbaum, JC Faye, S Séronie-Vivien, MJ Rogers, JR Green, D Amin, JD Bergstrom, K Thompson, E van Beek, HL Benford, SP Luckman, T Iguchi, JE Fisher, K Sawada, C Denoyelle, FP Coxon, ER Van Beek, GM Oades, SG Senaratne, SS Virtanen, F Saad, MR Smith, S Boissier, MV Lee, EC Lerner, TF McGuire, O Cussenot, P Skehan, AB Awad, E Corey, DC Crick, RB Lobell, SA Holstein, SE Ownby, C Allal, JE Dunford, JE Fisher   +40 more
core   +2 more sources

Farnesol inhibits translation to limit growth and filamentation in C. albicans and S. cerevisiae. [PDF]

, 2017
Candida albicans is a polymorphic yeast where the capacity to switch between yeast and filamentous growth is critical for pathogenicity. Farnesol is a quorum-sensing sesquiterpene alcohol that, via regulation of specific signalling and transcription ...
Ashe, M.P., Castelli, L.M., Dornelles, T.O., Egbe, N.E., Paget, C.M.   +4 more
core   +3 more sources

Quorum sensing in Candida albicans: probing farnesol's mode of action with 40 natural and synthetic farnesol analogs.

Chemistry & biology, 2004
The dimorphic fungus Candida albicans produces extracellular farnesol (3,7,11-trimethyl-2,6,10-dodecatriene-1-ol) which acts as a quorum-sensing molecule (QSM) to suppress filamentation. Of four possible geometric isomers of farnesol, only the E,E isomer possesses QSM activity.
Shchepin, Roman, Hornby, Jacob M., Burger, Erin, Niessen, Timothy, Dussault, Patrick H., Nickerson, Kenneth   +5 more
openaire   +2 more sources

Farnesol, a Fungal Quorum-Sensing Molecule Triggers Apoptosis in Human Oral Squamous Carcinoma Cells

Neoplasia: An International Journal for Oncology Research, 2008
Farnesol is a catabolite within the isoprenoid/cholesterol pathway that has exhibited significant antitumor activity. Farnesol was recently identified as a quorum-sensing molecule produced by the fungal pathogen Candida albicans.
Mark A. Scheper, Mark E. Shirtliff, Timothy F. Meiller, Brian M. Peters, Mary Ann Jabra-Rizk   +4 more
doaj   +1 more source