Results 131 to 140 of about 11,937 (188)

Combinatorial engineering of enzyme and pathway for efficient β-farnesene bioproduction in <i>Yarrowia lipolytica</i>. [PDF]

Synth Syst Biotechnol
Chen H, Su L, Yao Z, Jia K, Dai Z, Wang Q.   +5 more
europepmc   +1 more source

The mode of binding of nitrogen containing bisphosphonates in farnesyl pyrophosphate synthase

, 2016
Ebetino, F, Dunford, J, Lundy, M, Dao, X, Dobson, R, Triffitt, J, Quijano, M, Song, X, Boeckman, R, Russell, R, Barnett, B   +10 more
openaire   +1 more source

Cloning and structure-function analysis of farnesyl pyrophosphate synthase and geranylgeranyl pyrophosphate synthase from Lupinus albus

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Farnesyl pyrophosphate synthase

Enzyme Active Sites and their Reaction Mechanisms, 2021
Harry Morrison
exaly   +3 more sources

Expression of farnesyl pyrophosphate synthase is increased in diabetic cardiomyopathy

Cell Biology International, 2021
Farnesyl pyrophosphate synthase (FPPS)‐catalyzed isoprenoid intermediates are involved in diabetic cardiomyopathy. This study investigated the specific role of FPPS in the development of diabetic cardiomyopathy.
Zhengwei Li, Jiefang Zhang, Min Wang, Fuyu Qiu, Chong-ying Jin, G. Fu   +5 more
semanticscholar   +3 more sources

Fragment‐Based Discovery of Non‐bisphosphonate Binders of Trypanosoma brucei Farnesyl Pyrophosphate Synthase

ChemBioChem, 2020
Trypanosoma brucei is the causative agent of human African trypanosomiasis (HAT). Nitrogen‐containing bisphosphonates, a current treatment for bone diseases, have been shown to block the growth of the T.
Joy Kristin Petrick, Irina Cornaciu, Lena Muenzker   +2 more
exaly   +2 more sources

Overexpression of farnesyl pyrophosphate synthase increases myocardial ischemia/reperfusion injury in mice.

Gene, 2018
Farnesyl pyrophosphate synthase (FPPS) is a vital enzyme in the mevalonate pathway. Our previous study has indicated that overexpression of FPPS increases hypoxia/reoxygenation (HR) injury in Heart-derived H9c2 Cells.
D. Dai, Xiaotong Sun, Jie Ding, Yuxiao Chen, Shenjiang Hu   +4 more
semanticscholar   +3 more sources

Ovarian transcriptome and metabolic responses of RNAi-mediated farnesyl pyrophosphate synthase knockdown in Neocaridina denticulata sinensis.

Genomics, 2022
Methyl farnesoate (MF) is considered the equivalent of JH in crustaceans and plays an essential role in many crucial physiological processes. It is believed that farnesyl pyrophosphate synthase (FPPS) plays an essential role in the biosynthesis of ...
Mengfei Liu, Zixuan Wu, Congcong Yan, Yujie Liu, Kefan Xing, Jiquan Zhang, Yuying Sun   +6 more
semanticscholar   +1 more source

Design, synthesis, molecular docking, dynamics and in vitro evaluation of novel 2- substituted-1-hydroxyethane-1, 1-bis(phosphonic acid) derivatives as human farnesyl pyrophosphate synthase inhibitors with expected anticancer activity.

Current pharmaceutical design, 2022
BACKGROUND Nitrogenous bisphosphonates (NBPs) are the major class of drugs that are used to treat osteoporosis. Recently, bisphosphonates (BPs) were reported to have an anticancer effect.
M. Khedr, Reem I. Al-Wabli, Maha S Almutairi, W. Zaghary   +3 more
semanticscholar   +1 more source