Results 151 to 160 of about 11,937 (188)

Cloning, Expression Characteristics of Farnesyl Pyrophosphate Synthase Gene from Platycodon grandiflorus and Functional Identification in Triterpenoid Synthesis.

Journal of Agricultural and Food Chemistry
Platycodon grandiflorus is a medicinal plant whose main component is platycodins, which have a variety of pharmacological effects and nutritional values.
Meiqi Liu, Zhen Wang, Chen Qin, Hui-yan Cao, Lingyang Kong, Tingxia Liu, Shan Jiang, Lengleng Ma, Xiubo Liu, Weichao Ren, Wei Ma   +10 more
semanticscholar   +1 more source

Transcriptional regulation of farnesyl pyrophosphate synthase by liver X receptors

Steroids, 2003
Liver X receptors (LXRs) are members of the nuclear receptor superfamily that are involved in cholesterol and lipid metabolism. In addition to liver, the brain is another site where LXRs may control cholesterol homeostasis. In the brain, the regulation of cholesterol homeostasis is independent from other parts of the body, and its disturbance is ...
Junichi, Fukuchi, Ching, Song, Andrew L, Ko, Shutsung, Liao   +3 more
openaire   +2 more sources

Farnesyl Pyrophosphate Synthase Blocker Ibandronate Reduces Thoracic Aortic Fibrosis in Diabetic Rats

American Journal of the Medical Sciences, 2019
Background: This study assessed the effect of ibandronate (IBN), a farnesyl pyrophosphate synthase (FPPS) inhibitor, on vascular remodeling in diabetic rats.
Xiaowei Liu, Hong‐feng Jin, Changqing Du, Li-jiang Tang   +3 more
semanticscholar   +1 more source

Molecular cloning and characterization of farnesyl pyrophosphate synthase gene from Panax sokpayensis, a new Panax species from Sikkim Himalaya

Journal of Applied Research on Medicinal and Aromatic Plants, 2019
This study describes the molecular characterization and heterologous expression of farnesyl pyrophosphate synthase (PsFPS) from Panax sokpayensis Shiva K. Sharma & Pandit.
B. Gurung, Savita Bains, D. Saha, Kashmir Singh, P. Bhardwaj, D. Sahoo   +5 more
semanticscholar   +1 more source

Novel inhibitors of the human Farnesyl Pyrophosphate Synthase

2013
Tsantrizos, Youla S. (Supervisor)
openaire   +1 more source

Probing the Structures of Leishmanial Farnesyl Pyrophosphate Synthases: Homology Modeling and Docking Studies

Journal of Chemical Information and Modeling, 2008
Leishmania donovani and Leishmania major farnesyl pyrophosphate synthase ( LdFPPS and LmFPPS) are potential targets for the development of antileishmanial therapy. The protein sequence for LdFPPS was recently elucidated in our laboratory. Highly refined homology models were generated using the protein sequences of LdFPPS and the closely related LmFPPS ...
Prasenjit Mukherjee, Prashant V. Desai, Anuradha Srivastava, Babu L. Tekwani, Mitchell A. Avery   +4 more
openaire   +2 more sources

Structural Evidence ofN6-Isopentenyladenosine As a New Ligand of Farnesyl Pyrophosphate Synthase

Journal of Medicinal Chemistry, 2014
N6-isopentenyladenosine (i6A), a modified nucleoside belonging to the cytokinin family, has shown in humans many biological actions, including antitumoral effects through the modulation of the farnesyl pyrophosphate synthase (FPPS) activity. To investigate the relationship between i6A and FPPS, we undertook an inverse virtual screening computational ...
SCRIMA, MARIO, LAURO, GIANLUIGI, GRIMALDI, MANUELA, Sara Di Marino, TOSCO, ALESSANDRA, PICARDI, PAOLA, GAZZERRO, Patrizia, RICCIO, Raffaele, Ettore Novellino, BIFULCO, Maurizio, BIFULCO, Giuseppe, D'URSI, Anna Maria   +11 more
openaire   +4 more sources

Selective in vitro effects of the farnesyl pyrophosphate synthase inhibitor risedronate on Trypanosoma cruzi

International Journal of Antimicrobial Agents, 2004
We present the results of the first detailed study of the molecular and cellular basis of the antiproliferative effects of the bisphosphonate risedronate (Ris) on Trypanosoma cruzi, the causative agent of Chagas' disease. Ris and related compounds, which block poly-isoprenoid biosynthesis at the level of farnesyl pyrophosphate synthase, are currently ...
Luciana R, Garzoni, Aura, Caldera, Maria de Nazareth L, Meirelles, Solange L, de Castro, Roberto, Docampo, Gary A, Meints, Eric, Oldfield, Julio A, Urbina   +7 more
openaire   +2 more sources

Human farnesyl pyrophosphate synthase inhibition by nitrogen bisphosphonates: a 3D-QSAR study

Journal of Computer-Aided Molecular Design, 2013
We report the results of a comparative molecular field analysis and comparative molecular similarity index analysis of the human farnesyl pyrophosphate synthase (FPPS) inhibition by nitrogen bisphosphonates (NBPs) taking into account their time-dependent inhibition efficacies.
David Fernández, Joaquín Ortega-Castro, Juan Frau   +2 more
openaire   +2 more sources

Conformationally rigidified inhibitors of human farnesyl pyrophosphate synthase

2014
The mevalonate pathway is important in all eukaryotic cells. One of the key enzymes in this pathway is the human farnesyl pyrophosphate synthase (hFPPS), which has a pivotal role in cell prenylation. Nitrogen containing bisphosphonates (N-BPs) are a class of drugs that have been shown to effectively inhibit hFPPS and improve the survival of patients ...
openaire   +1 more source