Results 161 to 170 of about 11,937 (188)

Frog farnesyl pyrophosphate synthases and their role as non-canonical terpene synthases for bisabolane sesquiterpenes

Organic & Biomolecular Chemistry
Three farnesyl pyrophosphate synthases from frogs have been characterised and shown to convert (2 Z ,6 E )-farnesyl pyrophosphate into bisabolane sesquiterpenes.
Kexin Yang, Houchao Xu, Miguel Vences, Andolalao Rakotoarison, Stefan Schulz, Jeroen S. Dickschat   +5 more
openaire   +3 more sources

Design and synthesis of bisphosphonate analogs as inhibitors of farnesyl pyrophosphate synthase

2015
Molecular modeling and synthetic studies were carried out on several novel analogs of risedronate, a nitrogen-containing bisphosphonate (N-BP) drug that is widely used for the treatment of osteoporosis and other bone diseases. The physicochemical properties of the side-chain nitrogen and its position relative to the bisphosphonate P-C-P backbone are ...
openaire   +1 more source

Tyrosine 92 of aristolochene synthase directs cyclisation of farnesyl pyrophosphate.

Chemical communications (Cambridge, England), 2003
A mutant of Aristolochene Synthase (AS), in which Tyr 92 was replaced by Val, produced the alicyclic beta-(E)-farnesene as the major product, indicating that cyclisation of FPP is controlled by Tyr 92 in AS.
Melanie J, Calvert, Susan E, Taylor, Rudolf K, Allemann   +2 more
openaire   +1 more source

The Design, Synthesis and Evaluation of Novel Inhibitors of Farnesyl Pyrophosphate Synthase

2022
Farnesyl pyrophosphate synthase (FPPS) is one of the enzymes in the cholesterol synthesis pathway. The important roles that FPPS plays in the body has led to the growing interest in developing FPPS inhibitors for anti-cancer therapies. Nitrogenous bisphosphonates are FPPS inhibitors and have been used for the treatment of skeletal conditions.
openaire   +1 more source

[Cloning and functional verification of farnesyl pyrophosphate synthase gene(AvFPS) from Aconitum vilmorinianum].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
Xue Wang, Guodong Li, Baogang Wang, Fu-Rong Xu, Xiao-hui Ma   +4 more
semanticscholar   +1 more source

Characterization of an (E, E)-farnesyl pyrophosphate synthase in Saxifraga stolonifera involved in triterpenoid biosynthesis

Plant Molecular Biology
Chengjiao Zhao, Jingxue Han, Shu-Yan Huang, Xueping Su, L. Cai, Hualei Wang, Jin Liang   +6 more
semanticscholar   +1 more source

A farnesyl pyrophosphate synthase gene expressed in pollen functions in S-RNase-independent unilateral incompatibility.

The Plant Journal, 2018
X. Qin, Wen-tao Li, Yang Liu, M. Tan, M. Ganal, R. Chetelat   +5 more
semanticscholar   +1 more source

Structure of 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase fromShewanella oneidensisat 1.6 Å: identification of farnesyl pyrophosphate trapped in a hydrophobic cavity

Acta Crystallographica Section D: Biological Crystallography, 2004
Michael Kennedy, Dirksen E Bussiere, Robinson H   +2 more
exaly  

Farnesyl Pyrophosphate Synthase: Real-Time Kinetics and Inhibition by Nitrogen-Containing Bisphosphonates in a Scintillation Assay

Assay and Drug Development Technologies, 2007
J Fraser Glickman
exaly  

Molecular cloning and expression of Chimonanthus praecox farnesyl pyrophosphate synthase gene and its possible involvement in the biosynthesis of floral volatile sesquiterpenoids

Plant Physiology and Biochemistry, 2010
Lin Xiang, Kaige Zhao, Long-Qing Chen
exaly